1hu9
From Proteopedia
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| - | [[Image:1hu9.jpg|left|200px]]<br /><applet load="1hu9" size=" | + | [[Image:1hu9.jpg|left|200px]]<br /><applet load="1hu9" size="350" color="white" frame="true" align="right" spinBox="true" |
caption="1hu9, resolution 2.2Å" /> | caption="1hu9, resolution 2.2Å" /> | ||
'''LIPOXYGENASE-3 (SOYBEAN) COMPLEX WITH 4-HYDROPEROXY-2-METHOXY-PHENOL'''<br /> | '''LIPOXYGENASE-3 (SOYBEAN) COMPLEX WITH 4-HYDROPEROXY-2-METHOXY-PHENOL'''<br /> | ||
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==About this Structure== | ==About this Structure== | ||
| - | 1HU9 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Glycine_max Glycine max] with FE and 4HM as [http://en.wikipedia.org/wiki/ligands ligands]. Active as [http://en.wikipedia.org/wiki/Lipoxygenase Lipoxygenase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.13.11.12 1.13.11.12] Known structural/functional Site: <scene name='pdbsite=FE3:Fe (Fe+3) Active Site'>FE3</scene>. Full crystallographic information is available from [http:// | + | 1HU9 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Glycine_max Glycine max] with <scene name='pdbligand=FE:'>FE</scene> and <scene name='pdbligand=4HM:'>4HM</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. Active as [http://en.wikipedia.org/wiki/Lipoxygenase Lipoxygenase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.13.11.12 1.13.11.12] Known structural/functional Site: <scene name='pdbsite=FE3:Fe+(Fe+3)+Active+Site'>FE3</scene>. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1HU9 OCA]. |
==Reference== | ==Reference== | ||
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[[Category: purple lipoxygenase]] | [[Category: purple lipoxygenase]] | ||
| - | ''Page seeded by [http:// | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Feb 3 09:50:17 2008'' |
Revision as of 07:50, 3 February 2008
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LIPOXYGENASE-3 (SOYBEAN) COMPLEX WITH 4-HYDROPEROXY-2-METHOXY-PHENOL
Overview
Scientific research provides documented evidence that fatty acid, metabolites have profound impact on carcinogenesis. Intervention into, dioxygenase pathways might therefore effect development, metastasis and, progression of many types of cancers. This work delivers the first 3D, structural data and explains how curcumin interacts with the fatty acid, metabolizing enzyme, soybean lipoxygenase. Curcumin binds to lipoxygenase, in a non-competitive manner. Trapped in that complex, it undergoes, photodegradation in the X-rays, but utilizes enzyme catalytic ability to, form the peroxy complex Enz-Fe-O-O-R as 4-hydroperoxy-2-methoxy-phenol, that later transforms into 2-methoxycyclohexa-2,5-diene-1,4-dione. Our, observations about this radiation and time-dependent inhibition add new, information to the role that curcumin might play in cancer prevention and, treatment.
About this Structure
1HU9 is a Single protein structure of sequence from Glycine max with and as ligands. Active as Lipoxygenase, with EC number 1.13.11.12 Known structural/functional Site: . Full crystallographic information is available from OCA.
Reference
Structure of curcumin in complex with lipoxygenase and its significance in cancer., Skrzypczak-Jankun E, Zhou K, McCabe NP, Selman SH, Jankun J, Int J Mol Med. 2003 Jul;12(1):17-24. PMID:12792803
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