1lpi
From Proteopedia
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| - | [[Image:1lpi.gif|left|200px]]<br /><applet load="1lpi" size=" | + | [[Image:1lpi.gif|left|200px]]<br /><applet load="1lpi" size="350" color="white" frame="true" align="right" spinBox="true" |
caption="1lpi, resolution 2.00Å" /> | caption="1lpi, resolution 2.00Å" /> | ||
'''HEW LYSOZYME: TRP...NA CATION-PI INTERACTION'''<br /> | '''HEW LYSOZYME: TRP...NA CATION-PI INTERACTION'''<br /> | ||
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==About this Structure== | ==About this Structure== | ||
| - | 1LPI is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Gallus_gallus Gallus gallus] with NA as [http://en.wikipedia.org/wiki/ligand ligand]. Active as [http://en.wikipedia.org/wiki/Lysozyme Lysozyme], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.1.17 3.2.1.17] Known structural/functional Site: <scene name='pdbsite=PON:Binding Site Of A Na Cation Stabilized By Pi-Cation Inte ...'>PON</scene>. Full crystallographic information is available from [http:// | + | 1LPI is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Gallus_gallus Gallus gallus] with <scene name='pdbligand=NA:'>NA</scene> as [http://en.wikipedia.org/wiki/ligand ligand]. Active as [http://en.wikipedia.org/wiki/Lysozyme Lysozyme], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.1.17 3.2.1.17] Known structural/functional Site: <scene name='pdbsite=PON:Binding+Site+Of+A+Na+Cation+Stabilized+By+Pi-Cation+Inte+...'>PON</scene>. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1LPI OCA]. |
==Reference== | ==Reference== | ||
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[[Category: o-glycosyl]] | [[Category: o-glycosyl]] | ||
| - | ''Page seeded by [http:// | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Feb 3 09:53:22 2008'' |
Revision as of 07:53, 3 February 2008
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HEW LYSOZYME: TRP...NA CATION-PI INTERACTION
Overview
Experimental evidence of a cation-pi interaction between a sodium cation, (Na+) and the indole ring of residue Trp123 in a structure (2.0 A) of hen, egg-white lysozyme is presented. The geometry of the metal ion-pi, interaction observed in the protein structure (distance between the, aromatic plane and the cation approximately 4 A) is consistent with, geometries observed among small molecules crystal structures and quantum, chemistry ab initio calculations. The present crystal structure of, lysozyme provides unique structural information about the geometry of, binding of cations to pi systems in proteins. It shows that the metal, ion-pi interaction within proteins is not significantly different from, similar bindings found in small molecules and that it can be modeled by, theoretical methods.
About this Structure
1LPI is a Single protein structure of sequence from Gallus gallus with as ligand. Active as Lysozyme, with EC number 3.2.1.17 Known structural/functional Site: . Full crystallographic information is available from OCA.
Reference
Cation-pi (Na+-Trp) interactions in the crystal structure of tetragonal lysozyme., Wouters J, Protein Sci. 1998 Nov;7(11):2472-5. PMID:9828016
Page seeded by OCA on Sun Feb 3 09:53:22 2008
Categories: Gallus gallus | Lysozyme | Single protein | Wouters, J. | NA | Glycosidase | Hydrolase | O-glycosyl
