3it6

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[[Image:3it6.png|left|200px]]
 
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{{STRUCTURE_3it6| PDB=3it6 | SCENE= }}
{{STRUCTURE_3it6| PDB=3it6 | SCENE= }}
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===The Crystal Structure of Ornithine Acetyltransferase complexed with Ornithine from Mycobacterium tuberculosis (Rv1653) at 2.4 A===
===The Crystal Structure of Ornithine Acetyltransferase complexed with Ornithine from Mycobacterium tuberculosis (Rv1653) at 2.4 A===
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{{ABSTRACT_PUBMED_20184895}}
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==Function==
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[[http://www.uniprot.org/uniprot/ARGJ_MYCTU ARGJ_MYCTU]] Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis: the synthesis of N-acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate (By similarity).[HAMAP-Rule:MF_01106]
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{{ABSTRACT_PUBMED_20184895}}
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==About this Structure==
==About this Structure==
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3IT6 is a 4 chains structure with sequences from [http://en.wikipedia.org/wiki/Mycobacterium_tuberculosis Mycobacterium tuberculosis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3IT6 OCA].
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[[3it6]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Mycobacterium_tuberculosis Mycobacterium tuberculosis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3IT6 OCA].
==Reference==
==Reference==
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<ref group="xtra">PMID:20184895</ref><references group="xtra"/>
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<ref group="xtra">PMID:020184895</ref><references group="xtra"/><references/>
[[Category: Glutamate N-acetyltransferase]]
[[Category: Glutamate N-acetyltransferase]]
[[Category: Mycobacterium tuberculosis]]
[[Category: Mycobacterium tuberculosis]]
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[[Category: Amino-acid biosynthesis]]
[[Category: Amino-acid biosynthesis]]
[[Category: Arginine biosynthesis]]
[[Category: Arginine biosynthesis]]
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[[Category: Cytoplasm]]
 
[[Category: Multifunctional enzyme]]
[[Category: Multifunctional enzyme]]
[[Category: Mycobacterium tuberculosis]]
[[Category: Mycobacterium tuberculosis]]
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[[Category: Structural genomic]]
[[Category: Structural genomic]]
[[Category: Transferase]]
[[Category: Transferase]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Apr 14 09:12:58 2010''
 

Revision as of 09:44, 27 March 2013

Template:STRUCTURE 3it6

Contents

The Crystal Structure of Ornithine Acetyltransferase complexed with Ornithine from Mycobacterium tuberculosis (Rv1653) at 2.4 A

Template:ABSTRACT PUBMED 20184895

Function

[ARGJ_MYCTU] Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis: the synthesis of N-acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate (By similarity).[HAMAP-Rule:MF_01106]

About this Structure

3it6 is a 4 chain structure with sequence from Mycobacterium tuberculosis. Full crystallographic information is available from OCA.

Reference

  • Sankaranarayanan R, Cherney MM, Garen C, Garen G, Niu C, Yuan M, James MN. The molecular structure of ornithine acetyltransferase from Mycobacterium tuberculosis bound to ornithine, a competitive inhibitor. J Mol Biol. 2010 Apr 9;397(4):979-90. Epub 2010 Feb 22. PMID:20184895 doi:10.1016/j.jmb.2010.02.018

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