From Proteopedia

proteopedia linkproteopedia link

Revision as of 19:23, 19 April 2010 (edit) Joel L. Sussman (Talk | contribs) (→'''Butyrylcholinesterase - BChE''') ← Previous diff		Revision as of 19:24, 19 April 2010 (edit) (undo) Joel L. Sussman (Talk | contribs) (→Butyrylcholinesterase - BChE) Next diff →
Line 23:		Line 23:
	=Butyrylcholinesterase - BChE=		=Butyrylcholinesterase - BChE=
-	== 2pm8, 1p0i – hBChE - human ==	+	== [[2pm8]], [[1p0i]] – hBChE - human ==

---

Revision as of 19:24, 19 April 2010

Butyrylcholinesterase - BuChE

Butyrylcholinesterase, also known as pseudocholinesterase, BCHE or BuChE, is an enzyme that, in humans, is encoded by the BCHE gene. Butyrylcholinesterase is also called serum cholinesterase. It is very similar to the neuronal acetylcholinesterase, and is a non-specific cholinesterase found in the blood plasma, which hydrolyses many different choline esters. Butyrylcholine is a synthetic compound and does not occur in the body naturally. It is used as a tool to distinguish between acetyl- and butyrylcholinesterase. The structure for this protein is available in its unmodified form (2pm8 and 1p0i)

One of the main functions of butyrylcholinesterase is its ability to remove and clean away organophosphorus nerve agents. This function and its inhibitors has been intensibely studied by solving protein structure of BChE in combination with organophosphate inhibitors and substrate inhibitors.

Proteopedia examples on these experiments and related publications are

Butyrylcholinesterase - BChE

2pm8, 1p0i – hBChE - human

BChE+organophosphate inhibitors causing irreversible inhibition

2wsl, 2wig – hBChE+TA4 2wil, 2wij - hBChE+TA5 2wid, 2wif - hBChE+TA1 2wik - hBChE+TA6 3djy, 3dkk - hBChE+tabun 1xlu - hBChE+DFP 1xlw - hBChE+echothiophate 1p0q - hBChE+soman

BChE+inhibitor binding at surface of the protein

2j4c – hBChE+ HgCl2

BChE+ substrate analogues mimicking the binding of the substrate butyrylcholine

1p0m - hBChE+choline 1p0p - hBChE+butyrylthiocholine