103d
From Proteopedia
(New page: 200px<br /> <applet load="103d" size="450" color="white" frame="true" align="right" spinBox="true" caption="103d" /> '''THE UNUSUAL STRUCTURE OF THE HUMAN CENTROME...) |
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'''THE UNUSUAL STRUCTURE OF THE HUMAN CENTROMERE (GGA)2 MOTIF: UNPAIRED GUANOSINE RESIDUES STACKED BETWEEN SHEARED G(DOT)A PAIRS'''<br /> | '''THE UNUSUAL STRUCTURE OF THE HUMAN CENTROMERE (GGA)2 MOTIF: UNPAIRED GUANOSINE RESIDUES STACKED BETWEEN SHEARED G(DOT)A PAIRS'''<br /> | ||
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==About this Structure== | ==About this Structure== | ||
| - | 103D is a | + | 103D is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/ ]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=103D OCA]. |
==Reference== | ==Reference== | ||
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[[Category: nmr]] | [[Category: nmr]] | ||
| - | ''Page seeded by [http:// | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri Feb 15 15:27:50 2008'' |
Revision as of 13:27, 15 February 2008
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THE UNUSUAL STRUCTURE OF THE HUMAN CENTROMERE (GGA)2 MOTIF: UNPAIRED GUANOSINE RESIDUES STACKED BETWEEN SHEARED G(DOT)A PAIRS
Overview
The centromere of human chromosomes contains multiple repeats of the DNA, sequence d(TGGAA)n. This sequence has the interesting property of pairing, with itself to form stable duplexes. We have determined the solution, structure of the unusual DNA duplex 5'-TGGAATGGAA:TGGAATGGAA-3' at atomic, resolution. The duplex contains unpaired staggered guanosine residues, which co-stack by intercalation between sheared G.A and A.G base-pairs to, form an interesting new structural motif, the GA-bracketed G-stack. The, TGGAA repeat unit contains six "steps", four of which are not Watson-Crick, base-pairs.
About this Structure
103D is a Protein complex structure of sequences from [1]. Full crystallographic information is available from OCA.
Reference
The unusual structure of the human centromere (GGA)2 motif. Unpaired guanosine residues stacked between sheared G.A pairs., Chou SH, Zhu L, Reid BR, J Mol Biol. 1994 Dec 2;244(3):259-68. PMID:7966337
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