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3llp
From Proteopedia
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{{STRUCTURE_3llp| PDB=3llp | SCENE= }} | {{STRUCTURE_3llp| PDB=3llp | SCENE= }} | ||
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===1.8 Angstrom human fascin 1 crystal structure=== | ===1.8 Angstrom human fascin 1 crystal structure=== | ||
| + | {{ABSTRACT_PUBMED_20393565}} | ||
| - | + | ==Function== | |
| - | + | [[http://www.uniprot.org/uniprot/FSCN1_HUMAN FSCN1_HUMAN]] Organizes filamentous actin into bundles with a minimum of 4.1:1 actin/fascin ratio. Plays a role in the organization of actin filament bundles and the formation of microspikes, membrane ruffles, and stress fibers. Important for the formation of a diverse set of cell protrusions, such as filopodia, and for cell motility and migration.<ref>PMID:9362073</ref> <ref>PMID:9571235</ref> <ref>PMID:20137952</ref> <ref>PMID:20393565</ref> | |
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==About this Structure== | ==About this Structure== | ||
| - | + | [[3llp]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3LLP OCA]. | |
==Reference== | ==Reference== | ||
| - | <ref group="xtra">PMID: | + | <ref group="xtra">PMID:020393565</ref><references group="xtra"/><references/> |
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
[[Category: Chen, L.]] | [[Category: Chen, L.]] | ||
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[[Category: Yang, S.]] | [[Category: Yang, S.]] | ||
[[Category: Zhang, J J.]] | [[Category: Zhang, J J.]] | ||
| - | [[Category: Acetylation]] | ||
[[Category: Actin bundling protein]] | [[Category: Actin bundling protein]] | ||
[[Category: Actin-binding]] | [[Category: Actin-binding]] | ||
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[[Category: Cancer]] | [[Category: Cancer]] | ||
[[Category: Cell migration]] | [[Category: Cell migration]] | ||
| - | [[Category: Cytoplasm]] | ||
[[Category: Metastasis]] | [[Category: Metastasis]] | ||
[[Category: Phosphoprotein]] | [[Category: Phosphoprotein]] | ||
[[Category: Protein binding]] | [[Category: Protein binding]] | ||
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| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Apr 28 10:49:56 2010'' | ||
Revision as of 20:06, 4 April 2013
Contents |
1.8 Angstrom human fascin 1 crystal structure
Template:ABSTRACT PUBMED 20393565
Function
[FSCN1_HUMAN] Organizes filamentous actin into bundles with a minimum of 4.1:1 actin/fascin ratio. Plays a role in the organization of actin filament bundles and the formation of microspikes, membrane ruffles, and stress fibers. Important for the formation of a diverse set of cell protrusions, such as filopodia, and for cell motility and migration.[1] [2] [3] [4]
About this Structure
3llp is a 2 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA.
Reference
- Chen L, Yang S, Jakoncic J, Zhang JJ, Huang XY. Migrastatin analogues target fascin to block tumour metastasis. Nature. 2010 Apr 15;464(7291):1062-6. PMID:20393565 doi:10.1038/nature08978
- ↑ Adams JC. Characterization of cell-matrix adhesion requirements for the formation of fascin microspikes. Mol Biol Cell. 1997 Nov;8(11):2345-63. PMID:9362073
- ↑ Yamashiro S, Yamakita Y, Ono S, Matsumura F. Fascin, an actin-bundling protein, induces membrane protrusions and increases cell motility of epithelial cells. Mol Biol Cell. 1998 May;9(5):993-1006. PMID:9571235
- ↑ Li A, Dawson JC, Forero-Vargas M, Spence HJ, Yu X, Konig I, Anderson K, Machesky LM. The actin-bundling protein fascin stabilizes actin in invadopodia and potentiates protrusive invasion. Curr Biol. 2010 Feb 23;20(4):339-45. doi: 10.1016/j.cub.2009.12.035. Epub 2010, Feb 4. PMID:20137952 doi:10.1016/j.cub.2009.12.035
- ↑ Chen L, Yang S, Jakoncic J, Zhang JJ, Huang XY. Migrastatin analogues target fascin to block tumour metastasis. Nature. 2010 Apr 15;464(7291):1062-6. PMID:20393565 doi:10.1038/nature08978
