3ik3

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{{STRUCTURE_3ik3| PDB=3ik3 | SCENE= }}
{{STRUCTURE_3ik3| PDB=3ik3 | SCENE= }}
===AP24534, a Pan-BCR-ABL Inhibitor for Chronic Myeloid Leukemia, Potently Inhibits the T315I Mutant and Overcomes Mutation-Based Resistance===
===AP24534, a Pan-BCR-ABL Inhibitor for Chronic Myeloid Leukemia, Potently Inhibits the T315I Mutant and Overcomes Mutation-Based Resistance===
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{{ABSTRACT_PUBMED_19878872}}
{{ABSTRACT_PUBMED_19878872}}
==About this Structure==
==About this Structure==
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3IK3 is a 2 chains structure with sequences from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3IK3 OCA].
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[[3ik3]] is a 2 chain structure of [[Proto-oncogene tyrosine-protein kinase]] with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3IK3 OCA].
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==See Also==
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*[[Proto-oncogene tyrosine-protein kinase|Proto-oncogene tyrosine-protein kinase]]
==Reference==
==Reference==
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<ref group="xtra">PMID:19878872</ref><references group="xtra"/>
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<ref group="xtra">PMID:019878872</ref><references group="xtra"/>
[[Category: Mus musculus]]
[[Category: Mus musculus]]
[[Category: Non-specific protein-tyrosine kinase]]
[[Category: Non-specific protein-tyrosine kinase]]
[[Category: Zhou, T.]]
[[Category: Zhou, T.]]
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[[Category: Alternative splicing]]
 
[[Category: Atp-binding]]
[[Category: Atp-binding]]
[[Category: Bcr-abl]]
[[Category: Bcr-abl]]
[[Category: Cell adhesion]]
[[Category: Cell adhesion]]
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[[Category: Chromosomal rearrangement]]
 
[[Category: Cml]]
[[Category: Cml]]
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[[Category: Cytoplasm]]
 
[[Category: Cytoskeleton]]
[[Category: Cytoskeleton]]
[[Category: Drug resistance]]
[[Category: Drug resistance]]
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[[Category: T315i]]
[[Category: T315i]]
[[Category: Transferase]]
[[Category: Transferase]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Apr 28 10:53:11 2010''
 

Revision as of 09:33, 25 July 2012

Image:3ik3.png

Template:STRUCTURE 3ik3

Contents

AP24534, a Pan-BCR-ABL Inhibitor for Chronic Myeloid Leukemia, Potently Inhibits the T315I Mutant and Overcomes Mutation-Based Resistance

Template:ABSTRACT PUBMED 19878872

About this Structure

3ik3 is a 2 chain structure of Proto-oncogene tyrosine-protein kinase with sequence from Mus musculus. Full crystallographic information is available from OCA.

See Also

Reference

  • O'Hare T, Shakespeare WC, Zhu X, Eide CA, Rivera VM, Wang F, Adrian LT, Zhou T, Huang WS, Xu Q, Metcalf CA 3rd, Tyner JW, Loriaux MM, Corbin AS, Wardwell S, Ning Y, Keats JA, Wang Y, Sundaramoorthi R, Thomas M, Zhou D, Snodgrass J, Commodore L, Sawyer TK, Dalgarno DC, Deininger MW, Druker BJ, Clackson T. AP24534, a pan-BCR-ABL inhibitor for chronic myeloid leukemia, potently inhibits the T315I mutant and overcomes mutation-based resistance. Cancer Cell. 2009 Nov 6;16(5):401-12. PMID:19878872 doi:10.1016/j.ccr.2009.09.028

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OCA

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