3juv
From Proteopedia
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{{STRUCTURE_3juv| PDB=3juv | SCENE= }} | {{STRUCTURE_3juv| PDB=3juv | SCENE= }} | ||
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===Crystal structure of human lanosterol 14alpha-demethylase (CYP51)=== | ===Crystal structure of human lanosterol 14alpha-demethylase (CYP51)=== | ||
| + | {{ABSTRACT_PUBMED_020149798}} | ||
| + | ==Function== | ||
| + | [[http://www.uniprot.org/uniprot/CP51A_HUMAN CP51A_HUMAN]] Catalyzes C14-demethylation of lanosterol; it transforms lanosterol into 4,4'-dimethyl cholesta-8,14,24-triene-3-beta-ol. | ||
==About this Structure== | ==About this Structure== | ||
| - | + | [[3juv]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3JUV OCA]. | |
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| + | ==Reference== | ||
| + | <ref group="xtra">PMID:020149798</ref><references group="xtra"/><references/> | ||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
[[Category: Sterol 14-demethylase]] | [[Category: Sterol 14-demethylase]] | ||
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[[Category: Usanov, S A.]] | [[Category: Usanov, S A.]] | ||
[[Category: Weigelt, J.]] | [[Category: Weigelt, J.]] | ||
| - | [[Category: Alternative splicing]] | ||
[[Category: Cholesterol biosynthesis]] | [[Category: Cholesterol biosynthesis]] | ||
[[Category: Cytochrome p450]] | [[Category: Cytochrome p450]] | ||
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[[Category: Nadp]] | [[Category: Nadp]] | ||
[[Category: Oxidoreductase]] | [[Category: Oxidoreductase]] | ||
| - | [[Category: Polymorphism]] | ||
[[Category: Sgc]] | [[Category: Sgc]] | ||
[[Category: Steroid biosynthesis]] | [[Category: Steroid biosynthesis]] | ||
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[[Category: Structural genomics consortium]] | [[Category: Structural genomics consortium]] | ||
[[Category: Transmembrane]] | [[Category: Transmembrane]] | ||
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Revision as of 09:17, 27 March 2013
Contents |
Crystal structure of human lanosterol 14alpha-demethylase (CYP51)
Template:ABSTRACT PUBMED 020149798
Function
[CP51A_HUMAN] Catalyzes C14-demethylation of lanosterol; it transforms lanosterol into 4,4'-dimethyl cholesta-8,14,24-triene-3-beta-ol.
About this Structure
3juv is a 1 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA.
Reference
- Strushkevich N, Usanov SA, Park HW. Structural basis of human CYP51 inhibition by antifungal azoles. J Mol Biol. 2010 Apr 9;397(4):1067-78. Epub 2010 Feb 10. PMID:20149798 doi:10.1016/j.jmb.2010.01.075
Categories: Homo sapiens | Sterol 14-demethylase | Arrowsmith, C H. | Bountra, C. | Edwards, A M. | MacKenzie, F. | Park, H. | SGC, Structural Genomics Consortium. | Strushkevich, N. | Usanov, S A. | Weigelt, J. | Cholesterol biosynthesis | Cytochrome p450 | Endoplasmic reticulum | Heme | Iron | Lipid synthesis | Membrane | Metal-binding | Microsome | Monooxygenase | Nadp | Oxidoreductase | Sgc | Steroid biosynthesis | Sterol 14alpha-demethylase | Sterol biosynthesis | Structural genomic | Structural genomics consortium | Transmembrane
