1usx
From Proteopedia
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| - | [[Image:1usx.gif|left|200px]]<br /><applet load="1usx" size=" | + | [[Image:1usx.gif|left|200px]]<br /><applet load="1usx" size="350" color="white" frame="true" align="right" spinBox="true" |
caption="1usx, resolution 2.7Å" /> | caption="1usx, resolution 2.7Å" /> | ||
'''CRYSTAL STRUCTURE OF THE NEWCASTLE DISEASE VIRUS HEMAGGLUTININ-NEURAMINIDASE COMPLEXED WITH THIOSIALOSIDE'''<br /> | '''CRYSTAL STRUCTURE OF THE NEWCASTLE DISEASE VIRUS HEMAGGLUTININ-NEURAMINIDASE COMPLEXED WITH THIOSIALOSIDE'''<br /> | ||
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==About this Structure== | ==About this Structure== | ||
| - | 1USX is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Newcastle_disease_virus Newcastle disease virus] with SIA, DAN and WIA as [http://en.wikipedia.org/wiki/ligands ligands]. Active as [http://en.wikipedia.org/wiki/Exo-alpha-sialidase Exo-alpha-sialidase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.1.18 3.2.1.18] Known structural/functional Site: <scene name='pdbsite=AC1:Dan Binding Site For Chain C'>AC1</scene>. Full crystallographic information is available from [http:// | + | 1USX is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Newcastle_disease_virus Newcastle disease virus] with <scene name='pdbligand=SIA:'>SIA</scene>, <scene name='pdbligand=DAN:'>DAN</scene> and <scene name='pdbligand=WIA:'>WIA</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. Active as [http://en.wikipedia.org/wiki/Exo-alpha-sialidase Exo-alpha-sialidase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.1.18 3.2.1.18] Known structural/functional Site: <scene name='pdbsite=AC1:Dan+Binding+Site+For+Chain+C'>AC1</scene>. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1USX OCA]. |
==Reference== | ==Reference== | ||
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[[Category: sialidase]] | [[Category: sialidase]] | ||
| - | ''Page seeded by [http:// | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Feb 3 10:04:33 2008'' |
Revision as of 08:04, 3 February 2008
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CRYSTAL STRUCTURE OF THE NEWCASTLE DISEASE VIRUS HEMAGGLUTININ-NEURAMINIDASE COMPLEXED WITH THIOSIALOSIDE
Overview
Paramyxoviruses are the leading cause of respiratory disease in children., Several paramyxoviruses possess a surface glycoprotein, the, hemagglutinin-neuraminidase (HN), that is involved in attachment to sialic, acid receptors, promotion of fusion, and removal of sialic acid from, infected cells and progeny virions. Previously we showed that Newcastle, disease virus (NDV) HN contained a pliable sialic acid recognition site, that could take two states, a binding state and a catalytic state. Here we, present evidence for a second sialic acid binding site at the dimer, interface of HN and present a model for its involvement in cell fusion., Three different crystal forms of NDV HN now reveal identical tetrameric, arrangements of HN monomers, perhaps indicative of the tetramer, association found on the viral surface.
About this Structure
1USX is a Single protein structure of sequence from Newcastle disease virus with , and as ligands. Active as Exo-alpha-sialidase, with EC number 3.2.1.18 Known structural/functional Site: . Full crystallographic information is available from OCA.
Reference
Second sialic acid binding site in Newcastle disease virus hemagglutinin-neuraminidase: implications for fusion., Zaitsev V, von Itzstein M, Groves D, Kiefel M, Takimoto T, Portner A, Taylor G, J Virol. 2004 Apr;78(7):3733-41. PMID:15016893
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