3l4h
From Proteopedia
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{{STRUCTURE_3l4h| PDB=3l4h | SCENE= }} | {{STRUCTURE_3l4h| PDB=3l4h | SCENE= }} | ||
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===Helical box domain and second WW domain of the human E3 ubiquitin-protein ligase HECW1=== | ===Helical box domain and second WW domain of the human E3 ubiquitin-protein ligase HECW1=== | ||
| + | ==Function== | ||
| + | [[http://www.uniprot.org/uniprot/HECW1_HUMAN HECW1_HUMAN]] E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent degradation of DVL1. Also targets the mutant SOD1 protein involved in familial amyotrophic lateral sclerosis (FALS). Forms cytotoxic aggregates with DVL1, SSR3 and mutant SOD1 that lead to motor neuron death in FALS. | ||
==About this Structure== | ==About this Structure== | ||
| - | + | [[3l4h]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3L4H OCA]. | |
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| + | ==See Also== | ||
| + | *[[Ubiquitin protein ligase|Ubiquitin protein ligase]] | ||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
[[Category: Arrowsmith, C H.]] | [[Category: Arrowsmith, C H.]] | ||
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[[Category: Walker, J R.]] | [[Category: Walker, J R.]] | ||
[[Category: Weigelt, J.]] | [[Category: Weigelt, J.]] | ||
| - | [[Category: Coiled coil]] | ||
| - | [[Category: Cytoplasm]] | ||
[[Category: E3 ligase]] | [[Category: E3 ligase]] | ||
[[Category: Helical box domain]] | [[Category: Helical box domain]] | ||
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[[Category: Ubl-conjugation pathway]] | [[Category: Ubl-conjugation pathway]] | ||
[[Category: Ww domain]] | [[Category: Ww domain]] | ||
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Revision as of 20:00, 4 April 2013
Contents |
Helical box domain and second WW domain of the human E3 ubiquitin-protein ligase HECW1
Function
[HECW1_HUMAN] E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent degradation of DVL1. Also targets the mutant SOD1 protein involved in familial amyotrophic lateral sclerosis (FALS). Forms cytotoxic aggregates with DVL1, SSR3 and mutant SOD1 that lead to motor neuron death in FALS.
About this Structure
3l4h is a 1 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA.
See Also
Categories: Homo sapiens | Arrowsmith, C H. | Botchkarev, A. | Bountra, C. | Dhe-Paganon, S. | Edwards, A M. | Li, Y. | Qiu, L. | SGC, Structural Genomics Consortium. | Walker, J R. | Weigelt, J. | E3 ligase | Helical box domain | Ligase | Protein binding | Sgc | Structural genomic | Structural genomics consortium | Ubl-conjugation pathway | Ww domain
