This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.
Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.
1uw1
From Proteopedia
| Line 1: | Line 1: | ||
| - | [[Image:1uw1.jpg|left|200px]]<br /><applet load="1uw1" size=" | + | [[Image:1uw1.jpg|left|200px]]<br /><applet load="1uw1" size="350" color="white" frame="true" align="right" spinBox="true" |
caption="1uw1, resolution 1.94Å" /> | caption="1uw1, resolution 1.94Å" /> | ||
'''A NOVEL ADP- AND ZINC-BINDING FOLD FROM FUNCTION-DIRECTED IN VITRO EVOLUTION'''<br /> | '''A NOVEL ADP- AND ZINC-BINDING FOLD FROM FUNCTION-DIRECTED IN VITRO EVOLUTION'''<br /> | ||
| Line 7: | Line 7: | ||
==About this Structure== | ==About this Structure== | ||
| - | 1UW1 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/ ] with ZN and ADP as [http://en.wikipedia.org/wiki/ligands ligands]. Known structural/functional Site: <scene name='pdbsite=AC1:Zn Binding Site For Chain A'>AC1</scene>. Full crystallographic information is available from [http:// | + | 1UW1 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/ ] with <scene name='pdbligand=ZN:'>ZN</scene> and <scene name='pdbligand=ADP:'>ADP</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. Known structural/functional Site: <scene name='pdbsite=AC1:Zn+Binding+Site+For+Chain+A'>AC1</scene>. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1UW1 OCA]. |
==Reference== | ==Reference== | ||
| Line 21: | Line 21: | ||
[[Category: nucleotide binding protein]] | [[Category: nucleotide binding protein]] | ||
| - | ''Page seeded by [http:// | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Feb 3 10:08:31 2008'' |
Revision as of 08:08, 3 February 2008
|
A NOVEL ADP- AND ZINC-BINDING FOLD FROM FUNCTION-DIRECTED IN VITRO EVOLUTION
Overview
A great challenge to biologists is to create proteins with novel folds and, tailored functions. As an alternative to de novo protein design, we, investigated the structure of a randomly generated protein targeted to, bind ATP. The crystal structure reveals a novel alpha/beta fold bound to, its ligand, representing both the first protein structure derived from in, vitro evolution and the first nucleotide-binding protein stabilized by a, zinc ion.
About this Structure
1UW1 is a Single protein structure of sequence from [1] with and as ligands. Known structural/functional Site: . Full crystallographic information is available from OCA.
Reference
A novel ADP- and zinc-binding fold from function-directed in vitro evolution., Lo Surdo P, Walsh MA, Sollazzo M, Nat Struct Mol Biol. 2004 Apr;11(4):382-3. Epub 2004 Mar 14. PMID:15024384 [[Category: ]]
Page seeded by OCA on Sun Feb 3 10:08:31 2008
