1uw1
From Proteopedia
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| - | [[Image:1uw1.jpg|left|200px]]<br /><applet load="1uw1" size=" | + | [[Image:1uw1.jpg|left|200px]]<br /><applet load="1uw1" size="350" color="white" frame="true" align="right" spinBox="true" |
caption="1uw1, resolution 1.94Å" /> | caption="1uw1, resolution 1.94Å" /> | ||
'''A NOVEL ADP- AND ZINC-BINDING FOLD FROM FUNCTION-DIRECTED IN VITRO EVOLUTION'''<br /> | '''A NOVEL ADP- AND ZINC-BINDING FOLD FROM FUNCTION-DIRECTED IN VITRO EVOLUTION'''<br /> | ||
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==About this Structure== | ==About this Structure== | ||
| - | 1UW1 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/ ] with ZN and ADP as [http://en.wikipedia.org/wiki/ligands ligands]. Known structural/functional Site: <scene name='pdbsite=AC1:Zn Binding Site For Chain A'>AC1</scene>. Full crystallographic information is available from [http:// | + | 1UW1 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/ ] with <scene name='pdbligand=ZN:'>ZN</scene> and <scene name='pdbligand=ADP:'>ADP</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. Known structural/functional Site: <scene name='pdbsite=AC1:Zn+Binding+Site+For+Chain+A'>AC1</scene>. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1UW1 OCA]. |
==Reference== | ==Reference== | ||
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[[Category: nucleotide binding protein]] | [[Category: nucleotide binding protein]] | ||
| - | ''Page seeded by [http:// | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Feb 3 10:08:31 2008'' |
Revision as of 08:08, 3 February 2008
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A NOVEL ADP- AND ZINC-BINDING FOLD FROM FUNCTION-DIRECTED IN VITRO EVOLUTION
Overview
A great challenge to biologists is to create proteins with novel folds and, tailored functions. As an alternative to de novo protein design, we, investigated the structure of a randomly generated protein targeted to, bind ATP. The crystal structure reveals a novel alpha/beta fold bound to, its ligand, representing both the first protein structure derived from in, vitro evolution and the first nucleotide-binding protein stabilized by a, zinc ion.
About this Structure
1UW1 is a Single protein structure of sequence from [1] with and as ligands. Known structural/functional Site: . Full crystallographic information is available from OCA.
Reference
A novel ADP- and zinc-binding fold from function-directed in vitro evolution., Lo Surdo P, Walsh MA, Sollazzo M, Nat Struct Mol Biol. 2004 Apr;11(4):382-3. Epub 2004 Mar 14. PMID:15024384 [[Category: ]]
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