This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.

Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.


3lgf

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 1: Line 1:
-
{{Seed}}
 
-
[[Image:3lgf.png|left|200px]]
 
- 
-
<!--
 
-
The line below this paragraph, containing "STRUCTURE_3lgf", creates the "Structure Box" on the page.
 
-
You may change the PDB parameter (which sets the PDB file loaded into the applet)
 
-
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
 
-
or leave the SCENE parameter empty for the default display.
 
-
-->
 
{{STRUCTURE_3lgf| PDB=3lgf | SCENE= }}
{{STRUCTURE_3lgf| PDB=3lgf | SCENE= }}
- 
===Crystal structure of the 53BP1 tandem tudor domain in complex with p53K370me2===
===Crystal structure of the 53BP1 tandem tudor domain in complex with p53K370me2===
 +
{{ABSTRACT_PUBMED_20307547}}
 +
==Disease==
 +
[[http://www.uniprot.org/uniprot/TP53B_HUMAN TP53B_HUMAN]] Note=A chromosomal aberration involving TP53BP1 is found in a form of myeloproliferative disorder chronic with eosinophilia. Translocation t(5;15)(q33;q22) with PDGFRB creating a TP53BP1-PDGFRB fusion protein.
-
<!--
+
==Function==
-
The line below this paragraph, {{ABSTRACT_PUBMED_20307547}}, adds the Publication Abstract to the page
+
[[http://www.uniprot.org/uniprot/TP53B_HUMAN TP53B_HUMAN]] Plays a key role in the response to DNA damage. May have a role in checkpoint signaling during mitosis. Enhances TP53-mediated transcriptional activation.<ref>PMID:12364621</ref><ref>PMID:17190600</ref>
-
(as it appears on PubMed at http://www.pubmed.gov), where 20307547 is the PubMed ID number.
+
-
-->
+
-
{{ABSTRACT_PUBMED_20307547}}
+
==About this Structure==
==About this Structure==
-
3LGF is a 2 chains structure with sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3LGF OCA].
+
[[3lgf]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3LGF OCA].
==Reference==
==Reference==
-
<ref group="xtra">PMID:20307547</ref><references group="xtra"/>
+
<ref group="xtra">PMID:020307547</ref><references group="xtra"/><references/>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Kutateladze, T G.]]
[[Category: Kutateladze, T G.]]
Line 36: Line 26:
[[Category: Transcription]]
[[Category: Transcription]]
[[Category: Transcription regulation]]
[[Category: Transcription regulation]]
- 
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed May 12 10:37:38 2010''
 

Revision as of 03:47, 25 March 2013

Template:STRUCTURE 3lgf

Contents

Crystal structure of the 53BP1 tandem tudor domain in complex with p53K370me2

Template:ABSTRACT PUBMED 20307547

Disease

[TP53B_HUMAN] Note=A chromosomal aberration involving TP53BP1 is found in a form of myeloproliferative disorder chronic with eosinophilia. Translocation t(5;15)(q33;q22) with PDGFRB creating a TP53BP1-PDGFRB fusion protein.

Function

[TP53B_HUMAN] Plays a key role in the response to DNA damage. May have a role in checkpoint signaling during mitosis. Enhances TP53-mediated transcriptional activation.[1][2]

About this Structure

3lgf is a 2 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

  • Roy S, Musselman CA, Kachirskaia I, Hayashi R, Glass KC, Nix JC, Gozani O, Appella E, Kutateladze TG. Structural insight into p53 recognition by the 53BP1 tandem Tudor domain. J Mol Biol. 2010 May 14;398(4):489-96. Epub 2010 Mar 20. PMID:20307547 doi:10.1016/j.jmb.2010.03.024
  1. ↑ Wang B, Matsuoka S, Carpenter PB, Elledge SJ. 53BP1, a mediator of the DNA damage checkpoint. Science. 2002 Nov 15;298(5597):1435-8. Epub 2002 Oct 3. PMID:12364621 doi:10.1126/science.1076182
  2. ↑ Botuyan MV, Lee J, Ward IM, Kim JE, Thompson JR, Chen J, Mer G. Structural basis for the methylation state-specific recognition of histone H4-K20 by 53BP1 and Crb2 in DNA repair. Cell. 2006 Dec 29;127(7):1361-73. PMID:17190600 doi:10.1016/j.cell.2006.10.043

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/3lgf"
Personal tools