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3lgd

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[[Image:3lgd.png|left|200px]]
 
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{{STRUCTURE_3lgd| PDB=3lgd | SCENE= }}
{{STRUCTURE_3lgd| PDB=3lgd | SCENE= }}
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===Crystal structure of human adenosine deaminase growth factor, adenosine deaminase type 2 (ADA2)===
===Crystal structure of human adenosine deaminase growth factor, adenosine deaminase type 2 (ADA2)===
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{{ABSTRACT_PUBMED_20147294}}
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==Disease==
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[[http://www.uniprot.org/uniprot/CECR1_HUMAN CECR1_HUMAN]] Cat-eye syndrome.
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==Function==
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[[http://www.uniprot.org/uniprot/CECR1_HUMAN CECR1_HUMAN]] Adenosine deaminase that may contribute to the degradation of extracellular adenosine, a signaling molecule that controls a variety of cellular responses. Requires elevated adenosine levels for optimal enzyme activity. Binds to cell surfaces via proteoglycans and may play a role in the regulation of cell proliferation and differentiation, independently of its enzyme activity.<ref>PMID:20453107</ref> <ref>PMID:20147294</ref>
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(as it appears on PubMed at http://www.pubmed.gov), where 20147294 is the PubMed ID number.
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{{ABSTRACT_PUBMED_20147294}}
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==About this Structure==
==About this Structure==
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3LGD is a 2 chains structure with sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3LGD OCA].
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[[3lgd]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3LGD OCA].
==Reference==
==Reference==
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<ref group="xtra">PMID:20147294</ref><references group="xtra"/>
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<ref group="xtra">PMID:020147294</ref><references group="xtra"/><references/>
[[Category: Adenosine deaminase]]
[[Category: Adenosine deaminase]]
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu May 20 08:59:02 2010''
 

Revision as of 20:24, 4 April 2013

Template:STRUCTURE 3lgd

Contents

Crystal structure of human adenosine deaminase growth factor, adenosine deaminase type 2 (ADA2)

Template:ABSTRACT PUBMED 20147294

Disease

[CECR1_HUMAN] Cat-eye syndrome.

Function

[CECR1_HUMAN] Adenosine deaminase that may contribute to the degradation of extracellular adenosine, a signaling molecule that controls a variety of cellular responses. Requires elevated adenosine levels for optimal enzyme activity. Binds to cell surfaces via proteoglycans and may play a role in the regulation of cell proliferation and differentiation, independently of its enzyme activity.[1] [2]

About this Structure

3lgd is a 2 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

  • Zavialov AV, Yu X, Spillmann D, Lauvau G, Zavialov AV. Structural basis for the growth factor activity of human adenosine deaminase ADA2. J Biol Chem. 2010 Apr 16;285(16):12367-77. Epub 2010 Feb 9. PMID:20147294 doi:10.1074/jbc.M109.083527
  1. ↑ Zavialov AV, Gracia E, Glaichenhaus N, Franco R, Zavialov AV, Lauvau G. Human adenosine deaminase 2 induces differentiation of monocytes into macrophages and stimulates proliferation of T helper cells and macrophages. J Leukoc Biol. 2010 Aug;88(2):279-90. doi: 10.1189/jlb.1109764. Epub 2010 May 7. PMID:20453107 doi:10.1189/jlb.1109764
  2. ↑ Zavialov AV, Yu X, Spillmann D, Lauvau G, Zavialov AV. Structural basis for the growth factor activity of human adenosine deaminase ADA2. J Biol Chem. 2010 Apr 16;285(16):12367-77. Epub 2010 Feb 9. PMID:20147294 doi:10.1074/jbc.M109.083527

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