1w0i
From Proteopedia
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| - | [[Image:1w0i.gif|left|200px]]<br /><applet load="1w0i" size=" | + | [[Image:1w0i.gif|left|200px]]<br /><applet load="1w0i" size="350" color="white" frame="true" align="right" spinBox="true" |
caption="1w0i, resolution 2.10Å" /> | caption="1w0i, resolution 2.10Å" /> | ||
'''ARABIDOPSIS THALIANA MITOCHONDRIAL KAS'''<br /> | '''ARABIDOPSIS THALIANA MITOCHONDRIAL KAS'''<br /> | ||
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==About this Structure== | ==About this Structure== | ||
| - | 1W0I is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Arabidopsis_thaliana Arabidopsis thaliana] with K and SO4 as [http://en.wikipedia.org/wiki/ligands ligands]. Active as [http://en.wikipedia.org/wiki/Beta-ketoacyl-acyl-carrier-protein_synthase_I Beta-ketoacyl-acyl-carrier-protein synthase I], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.3.1.41 2.3.1.41] Known structural/functional Site: <scene name='pdbsite=KAA:So4 Binding Site For Chain B'>KAA</scene>. Full crystallographic information is available from [http:// | + | 1W0I is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Arabidopsis_thaliana Arabidopsis thaliana] with <scene name='pdbligand=K:'>K</scene> and <scene name='pdbligand=SO4:'>SO4</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. Active as [http://en.wikipedia.org/wiki/Beta-ketoacyl-acyl-carrier-protein_synthase_I Beta-ketoacyl-acyl-carrier-protein synthase I], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.3.1.41 2.3.1.41] Known structural/functional Site: <scene name='pdbsite=KAA:So4+Binding+Site+For+Chain+B'>KAA</scene>. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1W0I OCA]. |
==Reference== | ==Reference== | ||
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[[Category: synthase]] | [[Category: synthase]] | ||
| - | ''Page seeded by [http:// | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Feb 3 10:17:49 2008'' |
Revision as of 08:17, 3 February 2008
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ARABIDOPSIS THALIANA MITOCHONDRIAL KAS
Overview
Mitochondrial fatty acid synthesis is catalyzed by a dissociated fatty, acid synthase similar to those of plant plastids and bacteria. The crystal, structure of a mitochondrial beta-ketoacyl-[acyl carrier protein] synthase, (mtKAS), namely that from Arabidopsis thaliana, has been determined for, the first time. This enzyme accomplishes the vital condensation steps in, constructing fatty acid carbon skeletons. The product profile of mtKAS is, unusual in that C8 and C(14-16) fatty acyl chains predominate. An enzyme, architecture that likely is the basis for the observed bimodal profile of, mtKAS products can be derived from the shape of the acyl binding pocket.
About this Structure
1W0I is a Single protein structure of sequence from Arabidopsis thaliana with and as ligands. Active as Beta-ketoacyl-acyl-carrier-protein synthase I, with EC number 2.3.1.41 Known structural/functional Site: . Full crystallographic information is available from OCA.
Reference
Structure of the mitochondrial beta-ketoacyl-[acyl carrier protein] synthase from Arabidopsis and its role in fatty acid synthesis., Olsen JG, Rasmussen AV, von Wettstein-Knowles P, Henriksen A, FEBS Lett. 2004 Nov 5;577(1-2):170-4. PMID:15527780
Page seeded by OCA on Sun Feb 3 10:17:49 2008
Categories: Arabidopsis thaliana | Beta-ketoacyl-acyl-carrier-protein synthase I | Single protein | Henriksen, A. | Olsen, J.G. | Rasmussen, A.V. | Wettstein-Knowles, P.Von. | K | SO4 | Beta-ketoacyl-(acyl carrier protein) synthase | Condensing enzyme | Fatty acid elongation | Lipid metabolism | Synthase
