1w1w
From Proteopedia
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| - | [[Image:1w1w.gif|left|200px]]<br /><applet load="1w1w" size=" | + | [[Image:1w1w.gif|left|200px]]<br /><applet load="1w1w" size="350" color="white" frame="true" align="right" spinBox="true" |
caption="1w1w, resolution 2.9Å" /> | caption="1w1w, resolution 2.9Å" /> | ||
'''SC SMC1HD:SCC1-C COMPLEX, ATPGS'''<br /> | '''SC SMC1HD:SCC1-C COMPLEX, ATPGS'''<br /> | ||
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==About this Structure== | ==About this Structure== | ||
| - | 1W1W is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae] with MG and ATG as [http://en.wikipedia.org/wiki/ligands ligands]. Known structural/functional Site: <scene name='pdbsite=AC1:Mg Binding Site For Chain D'>AC1</scene>. Full crystallographic information is available from [http:// | + | 1W1W is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae] with <scene name='pdbligand=MG:'>MG</scene> and <scene name='pdbligand=ATG:'>ATG</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. Known structural/functional Site: <scene name='pdbsite=AC1:Mg+Binding+Site+For+Chain+D'>AC1</scene>. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1W1W OCA]. |
==Reference== | ==Reference== | ||
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[[Category: mitosis]] | [[Category: mitosis]] | ||
| - | ''Page seeded by [http:// | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Feb 3 10:18:15 2008'' |
Revision as of 08:18, 3 February 2008
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SC SMC1HD:SCC1-C COMPLEX, ATPGS
Overview
A multisubunit complex called cohesin forms a huge ring structure that, mediates sister chromatid cohesion, possibly by entrapping sister DNAs, following replication. Cohesin's kleisin subunit Scc1 completes the ring, connecting the ABC-like ATPase heads of a V-shaped Smc1/3 heterodimer., Proteolytic cleavage of Scc1 by separase triggers sister chromatid, disjunction, presumably by breaking the Scc1 bridge. One half of the, SMC-kleisin bridge is revealed here by a crystal structure of Smc1's, ATPase complexed with Scc1's C-terminal domain. The latter forms a winged, helix that binds a pair of beta strands in Smc1's ATPase head. Mutation of, conserved residues within the contact interface destroys Scc1's, interaction with Smc1/3 heterodimers and eliminates cohesin function., Interaction of Scc1's N terminus with Smc3 depends on prior C terminus, connection with Smc1. There is little or no turnover of Smc1-Scc1, interactions within cohesin complexes in vivo because expression of, noncleavable Scc1 after DNA replication does not hinder anaphase.
About this Structure
1W1W is a Protein complex structure of sequences from Saccharomyces cerevisiae with and as ligands. Known structural/functional Site: . Full crystallographic information is available from OCA.
Reference
Structure and stability of cohesin's Smc1-kleisin interaction., Haering CH, Schoffnegger D, Nishino T, Helmhart W, Nasmyth K, Lowe J, Mol Cell. 2004 Sep 24;15(6):951-64. PMID:15383284
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Categories: Protein complex | Saccharomyces cerevisiae | Haering, C. | Lowe, J. | Nasmyth, K. | ATG | MG | Abc atpase | Cell cycle | Chromosome segregation | Cohesin | Dimer | Kleisin | Mitosis
