1w2k

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[[Image:1w2k.gif|left|200px]]<br /><applet load="1w2k" size="450" color="white" frame="true" align="right" spinBox="true"
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[[Image:1w2k.gif|left|200px]]<br /><applet load="1w2k" size="350" color="white" frame="true" align="right" spinBox="true"
caption="1w2k, resolution 3.00&Aring;" />
caption="1w2k, resolution 3.00&Aring;" />
'''TF7A_4380 COMPLEX'''<br />
'''TF7A_4380 COMPLEX'''<br />
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==About this Structure==
==About this Structure==
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1W2K is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with FUC, BGC, CA, CAC and 380 as [http://en.wikipedia.org/wiki/ligands ligands]. Active as [http://en.wikipedia.org/wiki/Coagulation_factor_VIIa Coagulation factor VIIa], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.21.21 3.4.21.21] Known structural/functional Site: <scene name='pdbsite=AC1:Bgc Binding Site For Chain L'>AC1</scene>. Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1W2K OCA].
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1W2K is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with <scene name='pdbligand=FUC:'>FUC</scene>, <scene name='pdbligand=BGC:'>BGC</scene>, <scene name='pdbligand=CA:'>CA</scene>, <scene name='pdbligand=CAC:'>CAC</scene> and <scene name='pdbligand=380:'>380</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. Active as [http://en.wikipedia.org/wiki/Coagulation_factor_VIIa Coagulation factor VIIa], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.21.21 3.4.21.21] Known structural/functional Site: <scene name='pdbsite=AC1:Bgc+Binding+Site+For+Chain+L'>AC1</scene>. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1W2K OCA].
==Reference==
==Reference==
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[[Category: vitamin k]]
[[Category: vitamin k]]
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''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Tue Dec 18 18:27:31 2007''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Feb 3 10:18:30 2008''

Revision as of 08:18, 3 February 2008

Image:1w2k.gif

1w2k, resolution 3.00Å

Drag the structure with the mouse to rotate

TF7A_4380 COMPLEX

Contents

Overview

Proof of concept experiments have shown that tissue factor/factor VIIa, inhibitors have antithrombotic activity without enhancing bleeding, propensity. Starting from lead compounds generated by a biased, combinatorial approach, phenylglycine amide tissue factor/factor VIIa, inhibitors with low nanomolar affinity and good selectivity against other, serine proteases of the coagulation cascade were designed, using the, guidance of X-ray structural analysis and molecular modelling.

Disease

Known diseases associated with this structure: Esophageal squamous cell carcinoma OMIM:[606551], Factor VII deficiency OMIM:[227500], Myocardial infarction, decreased susceptibility to OMIM:[227500]

About this Structure

1W2K is a Protein complex structure of sequences from Homo sapiens with , , , and as ligands. Active as Coagulation factor VIIa, with EC number 3.4.21.21 Known structural/functional Site: . Full crystallographic information is available from OCA.

Reference

Design of selective phenylglycine amide tissue factor/factor VIIa inhibitors., Groebke Zbinden K, Banner DW, Ackermann J, D'Arcy A, Kirchhofer D, Ji YH, Tschopp TB, Wallbaum S, Weber L, Bioorg Med Chem Lett. 2005 Feb 1;15(3):817-22. PMID:15664864

Page seeded by OCA on Sun Feb 3 10:18:30 2008

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