1w31
From Proteopedia
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| - | [[Image:1w31.gif|left|200px]]<br /><applet load="1w31" size=" | + | [[Image:1w31.gif|left|200px]]<br /><applet load="1w31" size="350" color="white" frame="true" align="right" spinBox="true" |
caption="1w31, resolution 1.9Å" /> | caption="1w31, resolution 1.9Å" /> | ||
'''YEAST 5-AMINOLAEVULINIC ACID DEHYDRATASE 5-HYDROXYLAEVULINIC ACID COMPLEX'''<br /> | '''YEAST 5-AMINOLAEVULINIC ACID DEHYDRATASE 5-HYDROXYLAEVULINIC ACID COMPLEX'''<br /> | ||
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==About this Structure== | ==About this Structure== | ||
| - | 1W31 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae] with ZN and SHO as [http://en.wikipedia.org/wiki/ligands ligands]. Active as [http://en.wikipedia.org/wiki/Porphobilinogen_synthase Porphobilinogen synthase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.2.1.24 4.2.1.24] Known structural/functional Site: <scene name='pdbsite=AC1:Zn Binding Site For Chain A'>AC1</scene>. Full crystallographic information is available from [http:// | + | 1W31 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae] with <scene name='pdbligand=ZN:'>ZN</scene> and <scene name='pdbligand=SHO:'>SHO</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. Active as [http://en.wikipedia.org/wiki/Porphobilinogen_synthase Porphobilinogen synthase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.2.1.24 4.2.1.24] Known structural/functional Site: <scene name='pdbsite=AC1:Zn+Binding+Site+For+Chain+A'>AC1</scene>. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1W31 OCA]. |
==Reference== | ==Reference== | ||
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[[Category: zinc]] | [[Category: zinc]] | ||
| - | ''Page seeded by [http:// | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Feb 3 10:18:41 2008'' |
Revision as of 08:18, 3 February 2008
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YEAST 5-AMINOLAEVULINIC ACID DEHYDRATASE 5-HYDROXYLAEVULINIC ACID COMPLEX
Overview
The X-ray structure of the enzyme 5-aminolaevulinic acid dehydratase, (ALAD) from yeast complexed with the competitive inhibitor, 5-hydroxylaevulinic acid has been determined at a resolution of 1.9 A. The, structure shows that the inhibitor is bound by a Schiff-base link to one, of the invariant active-site lysine residues (Lys263). The inhibitor, appears to bind in two well defined conformations and the interactions, made by it suggest that it is a very close analogue of the substrate, 5-aminolaevulinic acid (ALA).
About this Structure
1W31 is a Single protein structure of sequence from Saccharomyces cerevisiae with and as ligands. Active as Porphobilinogen synthase, with EC number 4.2.1.24 Known structural/functional Site: . Full crystallographic information is available from OCA.
Reference
Structure of yeast 5-aminolaevulinic acid dehydratase complexed with the inhibitor 5-hydroxylaevulinic acid., Erskine PT, Coates L, Newbold R, Brindley AA, Stauffer F, Beaven GD, Gill R, Coker A, Wood SP, Warren MJ, Shoolingin-Jordan PM, Neier R, Cooper JB, Acta Crystallogr D Biol Crystallogr. 2005 Sep;61(Pt 9):1222-6. Epub 2005, Aug 16. PMID:16131755
Page seeded by OCA on Sun Feb 3 10:18:41 2008
Categories: Porphobilinogen synthase | Saccharomyces cerevisiae | Single protein | Beaven, G.D.E. | Brindley, A.A. | Coates, L. | Cooper, J.B. | Erskine, P.T. | Gill, R. | Neier, R. | Newbold, R. | Shoolingin-Jordan, P.M. | Stauffer, F. | Warren, M.J. | Wood, S.P. | SHO | ZN | Aldolase | Dehydratase | Heme biosynthesis | Lyase | Tetrapyrrole synthesis | Tim barrel | Zinc
