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3lms
From Proteopedia
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===Structure of human activated thrombin-activatable fibrinolysis inhibitor, TAFIa, in complex with tick-derived funnelin inhibitor, TCI.=== | ===Structure of human activated thrombin-activatable fibrinolysis inhibitor, TAFIa, in complex with tick-derived funnelin inhibitor, TCI.=== | ||
| + | {{ABSTRACT_PUBMED_20088943}} | ||
| - | + | ==Function== | |
| - | + | [[http://www.uniprot.org/uniprot/CBPB2_HUMAN CBPB2_HUMAN]] Cleaves C-terminal arginine or lysine residues from biologically active peptides such as kinins or anaphylatoxins in the circulation thereby regulating their activities. Down-regulates fibrinolysis by removing C-terminal lysine residues from fibrin that has already been partially degraded by plasmin.<ref>PMID:10574983</ref> | |
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==About this Structure== | ==About this Structure== | ||
| - | + | [[3lms]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [http://en.wikipedia.org/wiki/Rhipicephalus_bursa Rhipicephalus bursa]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3LMS OCA]. | |
==Reference== | ==Reference== | ||
| - | <ref group="xtra">PMID: | + | <ref group="xtra">PMID:020088943</ref><references group="xtra"/><references/> |
[[Category: Carboxypeptidase U]] | [[Category: Carboxypeptidase U]] | ||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
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[[Category: Valnickova, Z.]] | [[Category: Valnickova, Z.]] | ||
[[Category: Alpha-beta-hydrolase]] | [[Category: Alpha-beta-hydrolase]] | ||
| - | [[Category: Alternative splicing]] | ||
[[Category: Blood coagulation]] | [[Category: Blood coagulation]] | ||
[[Category: Carboxypeptidase]] | [[Category: Carboxypeptidase]] | ||
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[[Category: Metalloprotease]] | [[Category: Metalloprotease]] | ||
[[Category: Metalloprotease inhibitor]] | [[Category: Metalloprotease inhibitor]] | ||
| - | [[Category: Polymorphism]] | ||
[[Category: Protease]] | [[Category: Protease]] | ||
[[Category: Secreted]] | [[Category: Secreted]] | ||
| - | [[Category: Zinc]] | ||
[[Category: Zymogen]] | [[Category: Zymogen]] | ||
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| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jun 2 08:12:37 2010'' | ||
Revision as of 23:21, 10 April 2013
Contents |
Structure of human activated thrombin-activatable fibrinolysis inhibitor, TAFIa, in complex with tick-derived funnelin inhibitor, TCI.
Template:ABSTRACT PUBMED 20088943
Function
[CBPB2_HUMAN] Cleaves C-terminal arginine or lysine residues from biologically active peptides such as kinins or anaphylatoxins in the circulation thereby regulating their activities. Down-regulates fibrinolysis by removing C-terminal lysine residues from fibrin that has already been partially degraded by plasmin.[1]
About this Structure
3lms is a 2 chain structure with sequence from Homo sapiens and Rhipicephalus bursa. Full crystallographic information is available from OCA.
Reference
- Sanglas L, Arolas JL, Valnickova Z, Aviles FX, Enghild JJ, Gomis-Ruth FX. Insights into the molecular inactivation mechanism of human activated thrombin-activatable fibrinolysis inhibitor. J Thromb Haemost. 2010 May;8(5):1056-65. Epub 2010 Jan 17. PMID:20088943 doi:10.1111/j.1538-7836.2010.03740.x
- ↑ Mao SS, Cooper CM, Wood T, Shafer JA, Gardell SJ. Characterization of plasmin-mediated activation of plasma procarboxypeptidase B. Modulation by glycosaminoglycans. J Biol Chem. 1999 Dec 3;274(49):35046-52. PMID:10574983
Categories: Carboxypeptidase U | Homo sapiens | Rhipicephalus bursa | Arolas, J L. | Aviles, F X. | Enghild, J J. | Gomis-Ruth, F X. | Sanglas, L. | Valnickova, Z. | Alpha-beta-hydrolase | Blood coagulation | Carboxypeptidase | Cogaulation | Disulfide bond | Fibrinolysis | Funnelin | Glycoprotein | Hydrolase | Hydrolase-hydrolase inhibitor complex | Metal-binding | Metalloenzyme inhibitor | Metallopeptidase | Metalloprotease | Metalloprotease inhibitor | Protease | Secreted | Zymogen
