3lms

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[[Image:3lms.png|left|200px]]
 
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{{STRUCTURE_3lms| PDB=3lms | SCENE= }}
{{STRUCTURE_3lms| PDB=3lms | SCENE= }}
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===Structure of human activated thrombin-activatable fibrinolysis inhibitor, TAFIa, in complex with tick-derived funnelin inhibitor, TCI.===
===Structure of human activated thrombin-activatable fibrinolysis inhibitor, TAFIa, in complex with tick-derived funnelin inhibitor, TCI.===
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{{ABSTRACT_PUBMED_20088943}}
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==Function==
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[[http://www.uniprot.org/uniprot/CBPB2_HUMAN CBPB2_HUMAN]] Cleaves C-terminal arginine or lysine residues from biologically active peptides such as kinins or anaphylatoxins in the circulation thereby regulating their activities. Down-regulates fibrinolysis by removing C-terminal lysine residues from fibrin that has already been partially degraded by plasmin.<ref>PMID:10574983</ref>
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{{ABSTRACT_PUBMED_20088943}}
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==About this Structure==
==About this Structure==
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3LMS is a 2 chains structure with sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [http://en.wikipedia.org/wiki/Rhipicephalus_bursa Rhipicephalus bursa]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3LMS OCA].
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[[3lms]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [http://en.wikipedia.org/wiki/Rhipicephalus_bursa Rhipicephalus bursa]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3LMS OCA].
==Reference==
==Reference==
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<ref group="xtra">PMID:20088943</ref><references group="xtra"/>
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<ref group="xtra">PMID:020088943</ref><references group="xtra"/><references/>
[[Category: Carboxypeptidase U]]
[[Category: Carboxypeptidase U]]
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Alpha-beta-hydrolase]]
[[Category: Alpha-beta-hydrolase]]
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[[Category: Alternative splicing]]
 
[[Category: Blood coagulation]]
[[Category: Blood coagulation]]
[[Category: Carboxypeptidase]]
[[Category: Carboxypeptidase]]
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[[Category: Metalloprotease]]
[[Category: Metalloprotease]]
[[Category: Metalloprotease inhibitor]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jun 2 08:12:37 2010''
 

Revision as of 23:21, 10 April 2013

Template:STRUCTURE 3lms

Contents

Structure of human activated thrombin-activatable fibrinolysis inhibitor, TAFIa, in complex with tick-derived funnelin inhibitor, TCI.

Template:ABSTRACT PUBMED 20088943

Function

[CBPB2_HUMAN] Cleaves C-terminal arginine or lysine residues from biologically active peptides such as kinins or anaphylatoxins in the circulation thereby regulating their activities. Down-regulates fibrinolysis by removing C-terminal lysine residues from fibrin that has already been partially degraded by plasmin.[1]

About this Structure

3lms is a 2 chain structure with sequence from Homo sapiens and Rhipicephalus bursa. Full crystallographic information is available from OCA.

Reference

  • Sanglas L, Arolas JL, Valnickova Z, Aviles FX, Enghild JJ, Gomis-Ruth FX. Insights into the molecular inactivation mechanism of human activated thrombin-activatable fibrinolysis inhibitor. J Thromb Haemost. 2010 May;8(5):1056-65. Epub 2010 Jan 17. PMID:20088943 doi:10.1111/j.1538-7836.2010.03740.x
  1. ↑ Mao SS, Cooper CM, Wood T, Shafer JA, Gardell SJ. Characterization of plasmin-mediated activation of plasma procarboxypeptidase B. Modulation by glycosaminoglycans. J Biol Chem. 1999 Dec 3;274(49):35046-52. PMID:10574983

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