2xfk

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(New page: '''Unreleased structure''' The entry 2xfk is ON HOLD Authors: Clarke, B., Cutler, L., Demont, E., Dingwall, C., Dunsdon, R., Hawkins, J., Howes, C., Hussain, I., Maile, G., Matico, R., ...)
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'''Unreleased structure'''
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{{Seed}}
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[[Image:2xfk.jpg|left|200px]]
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The entry 2xfk is ON HOLD
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{{STRUCTURE_2xfk| PDB=2xfk | SCENE= }}
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Authors: Clarke, B., Cutler, L., Demont, E., Dingwall, C., Dunsdon, R., Hawkins, J., Howes, C., Hussain, I., Maile, G., Matico, R., Mosley, J., Naylor, A., O'Brien, A., Redshaw, S., Rowland, P., Soleil, V., Smith, K.J., Sweitzer, S., Theobald, P., Vesey, D., Walter, D.S., Wayne, G.
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===HUMAN BACE-1 IN COMPLEX WITH N-((1S,2R)-3-(((1S)-2-(CYCLOHEXYLAMINO)-1-METHYL-2-OXOETHYL)AMINO)-2-HYDROXY-1-(PHENYLMETHYL)PROPYL)-3-(ETHYLAMINO)-5-((METHYLSULFONYL)(PHENYL)AMINO)BENZAMIDE===
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Description: Human BACE-1 in complex with N-((1S,2R)-3-(((1S)-2-(cyclohexylamino)-1-methyl-2-oxoethyl)amino)-2-hydroxy-1-(phenylmethyl)propyl)-3-( ethylamino)-5-((methylsulfonyl)(phenyl)amino)benzamide
 
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jun 2 08:26:49 2010''
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(as it appears on PubMed at http://www.pubmed.gov), where 20579874 is the PubMed ID number.
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{{ABSTRACT_PUBMED_20579874}}
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==About this Structure==
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2XFK is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XFK OCA].
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==Reference==
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<ref group="xtra">PMID:20579874</ref><references group="xtra"/>
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[[Category: Homo sapiens]]
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[[Category: Memapsin 2]]
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[[Category: Brien, A O.]]
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[[Category: Clarke, B.]]
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[[Category: Cutler, L.]]
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[[Category: Demont, E.]]
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[[Category: Dingwall, C.]]
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[[Category: Dunsdon, R.]]
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[[Category: Hawkins, J.]]
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[[Category: Howes, C.]]
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[[Category: Hussain, I.]]
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[[Category: Maile, G.]]
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[[Category: Matico, R.]]
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[[Category: Mosley, J.]]
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[[Category: Naylor, A.]]
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[[Category: Redshaw, S.]]
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[[Category: Rowland, P.]]
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[[Category: Smith, K J.]]
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[[Category: Soleil, V.]]
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[[Category: Sweitzer, S.]]
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[[Category: Theobald, P.]]
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[[Category: Vesey, D.]]
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[[Category: Walter, D S.]]
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[[Category: Wayne, G.]]
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[[Category: Hydrolase]]
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[[Category: Protease]]
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[[Category: Zymogen]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jul 7 08:38:59 2010''

Revision as of 04:33, 7 July 2010

Image:2xfk.jpg

Template:STRUCTURE 2xfk

HUMAN BACE-1 IN COMPLEX WITH N-((1S,2R)-3-(((1S)-2-(CYCLOHEXYLAMINO)-1-METHYL-2-OXOETHYL)AMINO)-2-HYDROXY-1-(PHENYLMETHYL)PROPYL)-3-(ETHYLAMINO)-5-((METHYLSULFONYL)(PHENYL)AMINO)BENZAMIDE

Template:ABSTRACT PUBMED 20579874

About this Structure

2XFK is a 1 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

  • Clarke B, Cutler L, Demont E, Dingwall C, Dunsdon R, Hawkins J, Howes C, Hussain I, Maile G, Matico R, Mosley J, Naylor A, O'Brien A, Redshaw S, Rowland P, Soleil V, Smith KJ, Sweitzer S, Theobald P, Vesey D, Walter DS, Wayne G. BACE-1 hydroxyethylamine inhibitors using novel edge-to-face interaction with Arg-296. Bioorg Med Chem Lett. 2010 Aug 1;20(15):4639-44. Epub 2010 Jun 8. PMID:20579874 doi:10.1016/j.bmcl.2010.05.111

Page seeded by OCA on Wed Jul 7 08:38:59 2010

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