1svp

From Proteopedia

Revision as of 14:00, 30 October 2007

SINDBIS VIRUS CAPSID PROTEIN

Overview

BACKGROUND: Many enveloped viruses exit cells by budding from the plasma, membrane. The driving force for budding is the interaction of an inner, protein nucleocapsid core with transmembrane glycoprotein spikes. The, molecular details of this process are ill defined. Alphaviruses, such as, Sindbis virus (SINV) and Semliki Forest virus (SFV), represent some of the, simplest enveloped viruses and have been well characterized by structural, genetic and biochemical techniques. Although a high-resolution structure, of an alphavirus has not yet been attained, cryo-electron microscopy, (cryo-EM) has been used to show the multilayer organization at 25 A, resolution. In addition, atomic resolution studies are available of the, C-terminal domain of the nucleocapsid protein and this has been ... [(full description)]

About this Structure

1SVP is a [Single protein] structure of sequence from [Sindbis virus]. Structure known Active Site: TRI. Full crystallographic information is available from [OCA].

Reference

Identification of a protein binding site on the surface of the alphavirus nucleocapsid and its implication in virus assembly., Lee S, Owen KE, Choi HK, Lee H, Lu G, Wengler G, Brown DT, Rossmann MG, Kuhn RJ, Structure. 1996 May 15;4(5):531-41. PMID:8736552

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