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3mpm

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Revision as of 03:51, 16 June 2010

Image:3mpm.png

Template:STRUCTURE 3mpm

Contents

LCK complexed with a pyrazolopyrimidine

Template:ABSTRACT PUBMED 20483608

Disease

Known disease associated with this structure: SCID due to LCK deficiency OMIM:[153390]

About this Structure

3MPM is a 1 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

  • Gommermann N, Buehlmayer P, von Matt A, Breitenstein W, Masuya K, Pirard B, Furet P, Cowan-Jacob SW, Weckbecker G. New pyrazolo[1,5a]pyrimidines as orally active inhibitors of Lck. Bioorg Med Chem Lett. 2010 Jun 15;20(12):3628-31. Epub 2010 Apr 29. PMID:20483608 doi:10.1016/j.bmcl.2010.04.112

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