2xcn

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Revision as of 03:50, 16 June 2010

Image:2xcn.png

Template:STRUCTURE 2xcn

CRYSTAL STRUCTURE OF HCV NS3 PROTEASE WITH A BORONATE INHIBITOR

Template:ABSTRACT PUBMED 20493689

About this Structure

2XCN is a 4 chains structure with sequences from Hepatitis c virus. Full crystallographic information is available from OCA.

Reference

  • Li X, Zhang YK, Liu Y, Ding CZ, Li Q, Zhou Y, Plattner JJ, Baker SJ, Qian X, Fan D, Liao L, Ni ZJ, White GV, Mordaunt JE, Lazarides LX, Slater MJ, Jarvest RL, Thommes P, Ellis M, Edge CM, Hubbard JA, Somers D, Rowland P, Nassau P, McDowell B, Skarzynski TJ, Kazmierski WM, Grimes RM, Wright LL, Smith GK, Zou W, Wright J, Pennicott LE. Synthesis and evaluation of novel alpha-amino cyclic boronates as inhibitors of HCV NS3 protease. Bioorg Med Chem Lett. 2010 Jun 15;20(12):3550-6. Epub 2010 May 20. PMID:20493689 doi:10.1016/j.bmcl.2010.04.129

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