3mi2

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{{STRUCTURE_3mi2| PDB=3mi2 | SCENE= }}
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===Crystal structure of human orotidine-5'-monophosphate decarboxylase complexed with pyrazofurin monophosphate===
===Crystal structure of human orotidine-5'-monophosphate decarboxylase complexed with pyrazofurin monophosphate===
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{{ABSTRACT_PUBMED_20452222}}
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==Disease==
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[[http://www.uniprot.org/uniprot/PYR5_HUMAN PYR5_HUMAN]] Defects in UMPS are the cause of orotic aciduria type 1 (ORAC1) [MIM:[http://omim.org/entry/258900 258900]]. A disorder of pyrimidine metabolism resulting in megaloblastic anemia and orotic acid crystalluria that is frequently associated with some degree of physical and mental retardation. A minority of cases have additional features, particularly congenital malformations and immune deficiencies.<ref>PMID:9042911</ref>
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==About this Structure==
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[[3mi2]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3MI2 OCA].
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(as it appears on PubMed at http://www.pubmed.gov), where 20452222 is the PubMed ID number.
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{{ABSTRACT_PUBMED_20452222}}
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==About this Structure==
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==See Also==
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3MI2 is a 2 chains structure with sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3MI2 OCA].
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*[[Phosphoribosyltransferase|Phosphoribosyltransferase]]
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*[[Uridine 5'-monophosphate synthase|Uridine 5'-monophosphate synthase]]
==Reference==
==Reference==
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<ref group="xtra">PMID:20452222</ref><references group="xtra"/>
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<ref group="xtra">PMID:020452222</ref><references group="xtra"/><references/>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Orotidine-5'-phosphate decarboxylase]]
[[Category: Orotidine-5'-phosphate decarboxylase]]
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[[Category: Pyrazofurin monophosphate]]
[[Category: Pyrazofurin monophosphate]]
[[Category: Ump synthase]]
[[Category: Ump synthase]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jun 16 08:14:36 2010''
 

Revision as of 06:56, 25 March 2013

Template:STRUCTURE 3mi2

Contents

Crystal structure of human orotidine-5'-monophosphate decarboxylase complexed with pyrazofurin monophosphate

Template:ABSTRACT PUBMED 20452222

Disease

[PYR5_HUMAN] Defects in UMPS are the cause of orotic aciduria type 1 (ORAC1) [MIM:258900]. A disorder of pyrimidine metabolism resulting in megaloblastic anemia and orotic acid crystalluria that is frequently associated with some degree of physical and mental retardation. A minority of cases have additional features, particularly congenital malformations and immune deficiencies.[1]

About this Structure

3mi2 is a 2 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA.

See Also

Reference

  • Meza-Avina ME, Wei L, Liu Y, Poduch E, Bello AM, Mishra RK, Pai EF, Kotra LP. Structural determinants for the inhibitory ligands of orotidine-5'-monophosphate decarboxylase. Bioorg Med Chem. 2010 Jun 1;18(11):4032-41. Epub 2010 Apr 9. PMID:20452222 doi:10.1016/j.bmc.2010.04.017
  1. ↑ Suchi M, Mizuno H, Kawai Y, Tsuboi T, Sumi S, Okajima K, Hodgson ME, Ogawa H, Wada Y. Molecular cloning of the human UMP synthase gene and characterization of point mutations in two hereditary orotic aciduria families. Am J Hum Genet. 1997 Mar;60(3):525-39. PMID:9042911

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