3n4l

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'''Unreleased structure'''
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{{Seed}}
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[[Image:3n4l.jpg|left|200px]]
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The entry 3n4l is ON HOLD
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{{STRUCTURE_3n4l| PDB=3n4l | SCENE= }}
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Authors: Yao, N.H.
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===BACE-1 in complex with ELN380842===
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Description: BACE-1 in complex with ELN380842
 
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jun 16 08:28:56 2010''
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{{ABSTRACT_PUBMED_20634069}}
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==About this Structure==
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3N4L is a 3 chains structure with sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3N4L OCA].
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==Reference==
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<ref group="xtra">PMID:20634069</ref><references group="xtra"/>
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[[Category: Homo sapiens]]
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[[Category: Memapsin 2]]
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[[Category: Yao, N H.]]
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[[Category: Ad]]
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[[Category: Alzheimer's disease]]
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[[Category: Bace]]
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[[Category: Beta secretase]]
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[[Category: Beta-amyloid precursor protein]]
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[[Category: Beta-app]]
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[[Category: Hydrolase-hydrolase inhibitor complex]]
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[[Category: Hydroxyethylamine]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Nov 24 14:16:12 2010''

Revision as of 11:04, 24 November 2010

Image:3n4l.jpg

Template:STRUCTURE 3n4l

BACE-1 in complex with ELN380842

Template:ABSTRACT PUBMED 20634069

About this Structure

3N4L is a 3 chains structure with sequences from Homo sapiens. Full crystallographic information is available from OCA.

Reference

  • Truong AP, Probst GD, Aquino J, Fang L, Brogley L, Sealy JM, Hom RK, Tucker JA, John V, Tung JS, Pleiss MA, Konradi AW, Sham HL, Dappen MS, Toth G, Yao N, Brecht E, Pan H, Artis DR, Ruslim L, Bova MP, Sinha S, Yednock TA, Zmolek W, Quinn KP, Sauer JM. Improving the permeability of the hydroxyethylamine BACE-1 inhibitors: structure-activity relationship of P2' substituents. Bioorg Med Chem Lett. 2010 Aug 15;20(16):4789-94. Epub 2010 Jun 25. PMID:20634069 doi:10.1016/j.bmcl.2010.06.112

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