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2bp6
From Proteopedia
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| - | [[Image:2bp6.gif|left|200px]]<br /><applet load="2bp6" size=" | + | [[Image:2bp6.gif|left|200px]]<br /><applet load="2bp6" size="350" color="white" frame="true" align="right" spinBox="true" |
caption="2bp6, resolution 1.50Å" /> | caption="2bp6, resolution 1.50Å" /> | ||
'''CRYSTAL STRUCTURE OF PSEUDOMONAS AERUGINOSA LECTIN (PA-IIL) COMPLEXED WITH A-L-GALACTOPYRANOSIDE'''<br /> | '''CRYSTAL STRUCTURE OF PSEUDOMONAS AERUGINOSA LECTIN (PA-IIL) COMPLEXED WITH A-L-GALACTOPYRANOSIDE'''<br /> | ||
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==About this Structure== | ==About this Structure== | ||
| - | 2BP6 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Pseudomonas_aeruginosa Pseudomonas aeruginosa] with GXL, CA and SO4 as [http://en.wikipedia.org/wiki/ligands ligands]. Known structural/functional Site: <scene name='pdbsite=AC1:Ca Binding Site For Chain D'>AC1</scene>. Full crystallographic information is available from [http:// | + | 2BP6 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Pseudomonas_aeruginosa Pseudomonas aeruginosa] with <scene name='pdbligand=GXL:'>GXL</scene>, <scene name='pdbligand=CA:'>CA</scene> and <scene name='pdbligand=SO4:'>SO4</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. Known structural/functional Site: <scene name='pdbsite=AC1:Ca+Binding+Site+For+Chain+D'>AC1</scene>. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2BP6 OCA]. |
==Reference== | ==Reference== | ||
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[[Category: pseudomonas aeruginosa]] | [[Category: pseudomonas aeruginosa]] | ||
| - | ''Page seeded by [http:// | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Feb 3 10:26:35 2008'' |
Revision as of 08:26, 3 February 2008
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CRYSTAL STRUCTURE OF PSEUDOMONAS AERUGINOSA LECTIN (PA-IIL) COMPLEXED WITH A-L-GALACTOPYRANOSIDE
Overview
The lectin from Pseudomonas aeruginosa (PA-IIL) is involved in host, recognition and biofilm formation. Lectin not only displays an unusually, high affinity for fucose but also binds to L-fucose, L-galactose and, D-arabinose that differ only by the group at position 5 of the sugar ring., Isothermal calorimetry experiments provided precise determination of, affinity for the three methyl-glycosides and revealed a large enthalpy, contribution. The crystal structures of the complexes of PA-IIL with, L-galactose and Met-beta-D-arabinoside have been determined and compared, with the PA-IIL/fucose complex described previously. A combination of the, structures and thermodynamics provided clues for the role of the, hydrophobic group in affinity.
About this Structure
2BP6 is a Single protein structure of sequence from Pseudomonas aeruginosa with , and as ligands. Known structural/functional Site: . Full crystallographic information is available from OCA.
Reference
Binding of different monosaccharides by lectin PA-IIL from Pseudomonas aeruginosa: thermodynamics data correlated with X-ray structures., Sabin C, Mitchell EP, Pokorna M, Gautier C, Utille JP, Wimmerova M, Imberty A, FEBS Lett. 2006 Feb 6;580(3):982-7. Epub 2006 Jan 19. PMID:16438968
Page seeded by OCA on Sun Feb 3 10:26:35 2008
Categories: Pseudomonas aeruginosa | Single protein | Imberty, A. | Mitchell, E.P. | Sabin, C.D. | Wimmerova, M. | CA | GXL | SO4 | Calcium | Galactose | Lectin
