2bt4
From Proteopedia
| Line 1: | Line 1: | ||
| - | [[Image:2bt4.gif|left|200px]]<br /><applet load="2bt4" size=" | + | [[Image:2bt4.gif|left|200px]]<br /><applet load="2bt4" size="350" color="white" frame="true" align="right" spinBox="true" |
caption="2bt4, resolution 1.70Å" /> | caption="2bt4, resolution 1.70Å" /> | ||
'''TYPE II DEHYDROQUINASE INHIBITOR COMPLEX'''<br /> | '''TYPE II DEHYDROQUINASE INHIBITOR COMPLEX'''<br /> | ||
| Line 7: | Line 7: | ||
==About this Structure== | ==About this Structure== | ||
| - | 2BT4 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Streptomyces_coelicolor Streptomyces coelicolor] with PO4, CA2, TRS and GOL as [http://en.wikipedia.org/wiki/ligands ligands]. Active as [http://en.wikipedia.org/wiki/3-dehydroquinate_dehydratase 3-dehydroquinate dehydratase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.2.1.10 4.2.1.10] Known structural/functional Site: <scene name='pdbsite=AC1:Trs Binding Site For Chain L'>AC1</scene>. Full crystallographic information is available from [http:// | + | 2BT4 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Streptomyces_coelicolor Streptomyces coelicolor] with <scene name='pdbligand=PO4:'>PO4</scene>, <scene name='pdbligand=CA2:'>CA2</scene>, <scene name='pdbligand=TRS:'>TRS</scene> and <scene name='pdbligand=GOL:'>GOL</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. Active as [http://en.wikipedia.org/wiki/3-dehydroquinate_dehydratase 3-dehydroquinate dehydratase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.2.1.10 4.2.1.10] Known structural/functional Site: <scene name='pdbsite=AC1:Trs+Binding+Site+For+Chain+L'>AC1</scene>. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2BT4 OCA]. |
==Reference== | ==Reference== | ||
| Line 31: | Line 31: | ||
[[Category: shikimate pathway]] | [[Category: shikimate pathway]] | ||
| - | ''Page seeded by [http:// | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Feb 3 10:27:34 2008'' |
Revision as of 08:27, 3 February 2008
|
TYPE II DEHYDROQUINASE INHIBITOR COMPLEX
Overview
Selective inhibitors of type II dehydroquinase were rationally designed to, explore a second binding-pocket in the active-site. The molecular, modelling, synthesis, inhibition studies and crystal structure, determination are described.
About this Structure
2BT4 is a Single protein structure of sequence from Streptomyces coelicolor with , , and as ligands. Active as 3-dehydroquinate dehydratase, with EC number 4.2.1.10 Known structural/functional Site: . Full crystallographic information is available from OCA.
Reference
Rational design of new bifunctional inhibitors of type II dehydroquinase., Toscano MD, Stewart KA, Coggins JR, Lapthorn AJ, Abell C, Org Biomol Chem. 2005 Sep 7;3(17):3102-4. Epub 2005 Aug 1. PMID:16106291
Page seeded by OCA on Sun Feb 3 10:27:34 2008
Categories: 3-dehydroquinate dehydratase | Single protein | Streptomyces coelicolor | Abell, C. | Coggins, J.R. | Lapthorn, A.J. | Stewart, K.A. | Toscano, M.D. | CA2 | GOL | PO4 | TRS | Amino-acid biosynthesis | Aromatic amino acid biosynthesis | Dehydroquinase | Dehydroquinate | Drug design | Lyase | Shikimate pathway
