2buo
From Proteopedia
| Line 1: | Line 1: | ||
| - | [[Image:2buo.gif|left|200px]]<br /><applet load="2buo" size=" | + | [[Image:2buo.gif|left|200px]]<br /><applet load="2buo" size="350" color="white" frame="true" align="right" spinBox="true" |
caption="2buo, resolution 1.7Å" /> | caption="2buo, resolution 1.7Å" /> | ||
'''HIV-1 CAPSID C-TERMINAL DOMAIN IN COMPLEX WITH AN INHIBITOR OF PARTICLE ASSEMBLY'''<br /> | '''HIV-1 CAPSID C-TERMINAL DOMAIN IN COMPLEX WITH AN INHIBITOR OF PARTICLE ASSEMBLY'''<br /> | ||
| Line 7: | Line 7: | ||
==About this Structure== | ==About this Structure== | ||
| - | 2BUO is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/Human_immunodeficiency_virus_1 Human immunodeficiency virus 1] with ACY as [http://en.wikipedia.org/wiki/ligand ligand]. Known structural/functional Site: <scene name='pdbsite=AC1:Acy Binding Site For Chain A'>AC1</scene>. Full crystallographic information is available from [http:// | + | 2BUO is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/Human_immunodeficiency_virus_1 Human immunodeficiency virus 1] with <scene name='pdbligand=ACY:'>ACY</scene> as [http://en.wikipedia.org/wiki/ligand ligand]. Known structural/functional Site: <scene name='pdbsite=AC1:Acy+Binding+Site+For+Chain+A'>AC1</scene>. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2BUO OCA]. |
==Reference== | ==Reference== | ||
| Line 26: | Line 26: | ||
[[Category: polyprotein]] | [[Category: polyprotein]] | ||
| - | ''Page seeded by [http:// | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Feb 3 10:27:58 2008'' |
Revision as of 08:27, 3 February 2008
|
HIV-1 CAPSID C-TERMINAL DOMAIN IN COMPLEX WITH AN INHIBITOR OF PARTICLE ASSEMBLY
Overview
Immature HIV particles bud from infected cells after assembly at the, cytoplasmic side of cellular membranes. This assembly is driven by, interactions between Gag polyproteins. Mature particles, each containing a, characteristic conical core, are later generated by proteolytic maturation, of Gag in the virion. The C-terminal domain of the HIV-1 capsid protein, (C-CA) has been shown to contain oligomerization determinants essential, for particle assembly. Here we report the 1.7-A-resolution crystal, structure of C-CA in complex with a peptide capable of inhibiting, immature- and mature-like particle assembly in vitro. The peptide inserts, as an amphipathic alpha-helix into a conserved hydrophobic groove of C-CA, resulting in formation of a compact five-helix bundle with altered dimeric, interactions. This structure thus reveals the details of an allosteric, site in the HIV capsid protein that can be targeted for antiviral therapy.
About this Structure
2BUO is a Protein complex structure of sequences from Human immunodeficiency virus 1 with as ligand. Known structural/functional Site: . Full crystallographic information is available from OCA.
Reference
The HIV-1 capsid protein C-terminal domain in complex with a virus assembly inhibitor., Ternois F, Sticht J, Duquerroy S, Krausslich HG, Rey FA, Nat Struct Mol Biol. 2005 Aug;12(8):678-82. Epub 2005 Jul 24. PMID:16041386
Page seeded by OCA on Sun Feb 3 10:27:58 2008
