2c5m
From Proteopedia
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| - | [[Image:2c5m.gif|left|200px]]<br /><applet load="2c5m" size=" | + | [[Image:2c5m.gif|left|200px]]<br /><applet load="2c5m" size="350" color="white" frame="true" align="right" spinBox="true" |
caption="2c5m, resolution 2.8Å" /> | caption="2c5m, resolution 2.8Å" /> | ||
'''CRYSTAL STRUCTURE OF THE SYNTHETASE DOMAIN OF HUMAN CTP SYNTHETASE'''<br /> | '''CRYSTAL STRUCTURE OF THE SYNTHETASE DOMAIN OF HUMAN CTP SYNTHETASE'''<br /> | ||
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==About this Structure== | ==About this Structure== | ||
| - | 2C5M is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with SO4 as [http://en.wikipedia.org/wiki/ligand ligand]. Active as [http://en.wikipedia.org/wiki/CTP_synthase CTP synthase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=6.3.4.2 6.3.4.2] Known structural/functional Site: <scene name='pdbsite=AC1:So4 Binding Site For Chain A'>AC1</scene>. Full crystallographic information is available from [http:// | + | 2C5M is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with <scene name='pdbligand=SO4:'>SO4</scene> as [http://en.wikipedia.org/wiki/ligand ligand]. Active as [http://en.wikipedia.org/wiki/CTP_synthase CTP synthase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=6.3.4.2 6.3.4.2] Known structural/functional Site: <scene name='pdbsite=AC1:So4+Binding+Site+For+Chain+A'>AC1</scene>. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2C5M OCA]. |
==Reference== | ==Reference== | ||
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[[Category: utp]] | [[Category: utp]] | ||
| - | ''Page seeded by [http:// | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Feb 3 10:31:46 2008'' |
Revision as of 08:31, 3 February 2008
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CRYSTAL STRUCTURE OF THE SYNTHETASE DOMAIN OF HUMAN CTP SYNTHETASE
Overview
Cytidine triphosphate synthetase (CTPS) is a key enzyme in nucleic acid, and phospholipid biosynthesis and its activity is increased in certain, human cancers, making it a promising drug target. The crystal structure of, the synthetase domain of human CTPS, which represents the first structure, of a CTPS from an eukaryote, has been determined. The structure is, homotetrameric and each active site is formed by three different subunits., Sulfate ions bound to the active sites indicate the positions of, phosphate-binding sites for the substrates ATP and UTP and the feedback, inhibitor CTP. Together with earlier structures of bacterial CTPS, the, human CTPS structure provides an extended understanding of the, structure-function relationship of CTPS-family members. The structure also, serves as a basis for structure-based design of anti-proliferative, inhibitors.
About this Structure
2C5M is a Single protein structure of sequence from Homo sapiens with as ligand. Active as CTP synthase, with EC number 6.3.4.2 Known structural/functional Site: . Full crystallographic information is available from OCA.
Reference
Structure of the synthetase domain of human CTP synthetase, a target for anticancer therapy., Kursula P, Flodin S, Ehn M, Hammarstrom M, Schuler H, Nordlund P, Stenmark P, Acta Crystallograph Sect F Struct Biol Cryst Commun. 2006 Jul 1;62(Pt, 7):613-7. Epub 2006 Jun 10. PMID:16820675
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Categories: CTP synthase | Homo sapiens | Single protein | Arrowsmith, C. | Berg, S.Van.Den. | Berglund, H. | Edwards, A. | Ehn, M. | Flodin, S. | Graslund, S. | Hallberg, B.M. | Hammarstrom, M. | Kotenyova, T. | Kursula, P. | Nilsson-Ehle, P. | Nordlund, P. | Ogg, D. | Persson, C. | Sagemark, J. | Schiavone, L.Holmberg. | Schuler, H. | Stenmark, P. | Sundstrom, M. | Thorsell, A.G. | Weigelt, J. | SO4 | Amidotransferase | Ctp | Ctp synthase | Ctp synthetase | Ctps | Cytidine 5-prime triphosphate synthetase | Glutamine | Ligase | Phosphorylation | Pyrimidine biosynthesis | Utp
