3ndm

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'''Unreleased structure'''
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{{Seed}}
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[[Image:3ndm.jpg|left|200px]]
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The entry 3ndm is ON HOLD until Dec 07 2011
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{{STRUCTURE_3ndm| PDB=3ndm | SCENE= }}
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Authors: Li, X.
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===Crystal structure of Rho-Associated Protein Kinase (ROCK1) with a potent isoquinolone derivative===
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Description: Crystal structure of Rho-Associated Protein Kinase (ROCK1) with a potent isoquinolone derivative
 
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jul 7 08:28:49 2010''
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{{ABSTRACT_PUBMED_20471253}}
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==About this Structure==
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3NDM is a 4 chains structure with sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3NDM OCA].
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==Reference==
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<ref group="xtra">PMID:20471253</ref><ref group="xtra">PMID:20678931</ref><references group="xtra"/>
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[[Category: Homo sapiens]]
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[[Category: Non-specific serine/threonine protein kinase]]
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[[Category: Li, X.]]
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[[Category: Dimerization]]
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[[Category: Phosphorylation]]
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[[Category: Rho kinase]]
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[[Category: Transferase]]
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[[Category: Transferase-transferase inhibitor complex]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Dec 8 11:50:29 2010''

Revision as of 08:38, 8 December 2010

Image:3ndm.jpg

Template:STRUCTURE 3ndm

Crystal structure of Rho-Associated Protein Kinase (ROCK1) with a potent isoquinolone derivative

Template:ABSTRACT PUBMED 20471253

About this Structure

3NDM is a 4 chains structure with sequences from Homo sapiens. Full crystallographic information is available from OCA.

Reference

  • Bosanac T, Hickey ER, Ginn J, Kashem M, Kerr S, Kugler S, Li X, Olague A, Schlyer S, Young ER. Substituted 2H-isoquinolin-1-ones as potent Rho-kinase inhibitors: part 3, aryl substituted pyrrolidines. Bioorg Med Chem Lett. 2010 Jun 15;20(12):3746-9. Epub 2010 Apr 21. PMID:20471253 doi:10.1016/j.bmcl.2010.04.069
  • Ginn JD, Bosanac T, Chen R, Cywin C, Hickey E, Kashem M, Kerr S, Kugler S, Li X, Prokopowicz A 3rd, Schlyer S, Smith JD, Turner MR, Wu F, Young ER. Substituted 2H-isoquinolin-1-ones as potent Rho-kinase inhibitors: part 2, optimization for blood pressure reduction in spontaneously hypertensive rats. Bioorg Med Chem Lett. 2010 Sep 1;20(17):5153-6. Epub 2010 Aug 1. PMID:20678931 doi:10.1016/j.bmcl.2010.07.014

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