3mjh

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[[Image:3mjh.png|left|200px]]
 
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{{STRUCTURE_3mjh| PDB=3mjh | SCENE= }}
{{STRUCTURE_3mjh| PDB=3mjh | SCENE= }}
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===Crystal Structure of Human Rab5A in complex with the C2H2 Zinc Finger of EEA1===
===Crystal Structure of Human Rab5A in complex with the C2H2 Zinc Finger of EEA1===
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{{ABSTRACT_PUBMED_20534488}}
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==Function==
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[[http://www.uniprot.org/uniprot/RAB5A_HUMAN RAB5A_HUMAN]] Required for the fusion of plasma membranes and early endosomes. Contributes to the regulation of filopodia extension.<ref>PMID:14978216</ref> [[http://www.uniprot.org/uniprot/EEA1_HUMAN EEA1_HUMAN]] Binds phospholipid vesicles containing phosphatidylinositol 3-phosphate and participates in endosomal trafficking.
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{{ABSTRACT_PUBMED_20534488}}
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==About this Structure==
==About this Structure==
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3MJH is a 4 chains structure with sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3MJH OCA].
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[[3mjh]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3MJH OCA].
==Reference==
==Reference==
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<ref group="xtra">PMID:20534488</ref><references group="xtra"/>
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<ref group="xtra">PMID:020534488</ref><references group="xtra"/><references/>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Small monomeric GTPase]]
[[Category: Small monomeric GTPase]]
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[[Category: Protein-zinc finger complex]]
[[Category: Protein-zinc finger complex]]
[[Category: Rab5a gtpase]]
[[Category: Rab5a gtpase]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jul 14 15:59:02 2010''
 

Revision as of 20:59, 17 April 2013

Template:STRUCTURE 3mjh

Contents

Crystal Structure of Human Rab5A in complex with the C2H2 Zinc Finger of EEA1

Template:ABSTRACT PUBMED 20534488

Function

[RAB5A_HUMAN] Required for the fusion of plasma membranes and early endosomes. Contributes to the regulation of filopodia extension.[1] [EEA1_HUMAN] Binds phospholipid vesicles containing phosphatidylinositol 3-phosphate and participates in endosomal trafficking.

About this Structure

3mjh is a 4 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

  • Mishra A, Eathiraj S, Corvera S, Lambright DG. Structural basis for Rab GTPase recognition and endosome tethering by the C2H2 zinc finger of Early Endosomal Autoantigen 1 (EEA1). Proc Natl Acad Sci U S A. 2010 Jun 15;107(24):10866-71. Epub 2010 Jun 1. PMID:20534488
  1. ↑ Gauthier-Campbell C, Bredt DS, Murphy TH, El-Husseini Ael-D. Regulation of dendritic branching and filopodia formation in hippocampal neurons by specific acylated protein motifs. Mol Biol Cell. 2004 May;15(5):2205-17. Epub 2004 Feb 20. PMID:14978216 doi:10.1091/mbc.E03-07-0493

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