3jv3

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{{STRUCTURE_3jv3| PDB=3jv3 | SCENE= }}
{{STRUCTURE_3jv3| PDB=3jv3 | SCENE= }}
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===Structure of SH3E-DH unit of murine intersectin-1L===
===Structure of SH3E-DH unit of murine intersectin-1L===
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{{ABSTRACT_PUBMED_20585582}}
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==Function==
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[[http://www.uniprot.org/uniprot/ITSN1_MOUSE ITSN1_MOUSE]] Adapter protein that may provide indirect link between the endocytic membrane traffic and the actin assembly machinery. May regulate the formation of clathrin-coated vesicles. Involved in endocytosis of integrin beta-1 (ITGB1) and transferrin receptor (TFR); internalization of ITGB1 as DAB2-dependent cargo but not TFR may involve association with DAB2. Inhibits ARHGAP31 activity toward RAC1.
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{{ABSTRACT_PUBMED_20585582}}
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==About this Structure==
==About this Structure==
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3JV3 is a 2 chains structure with sequences from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3JV3 OCA].
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[[3jv3]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3JV3 OCA].
==Reference==
==Reference==
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<ref group="xtra">PMID:20585582</ref><references group="xtra"/>
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<ref group="xtra">PMID:020585582</ref><references group="xtra"/><references/>
[[Category: Mus musculus]]
[[Category: Mus musculus]]
[[Category: Ahmad, K F.]]
[[Category: Ahmad, K F.]]
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[[Category: Synapse]]
[[Category: Synapse]]
[[Category: Synaptosome]]
[[Category: Synaptosome]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jul 14 16:19:02 2010''
 

Revision as of 09:15, 27 March 2013

Template:STRUCTURE 3jv3

Contents

Structure of SH3E-DH unit of murine intersectin-1L

Template:ABSTRACT PUBMED 20585582

Function

[ITSN1_MOUSE] Adapter protein that may provide indirect link between the endocytic membrane traffic and the actin assembly machinery. May regulate the formation of clathrin-coated vesicles. Involved in endocytosis of integrin beta-1 (ITGB1) and transferrin receptor (TFR); internalization of ITGB1 as DAB2-dependent cargo but not TFR may involve association with DAB2. Inhibits ARHGAP31 activity toward RAC1.

About this Structure

3jv3 is a 2 chain structure with sequence from Mus musculus. Full crystallographic information is available from OCA.

Reference

  • Ahmad KF, Lim WA. The minimal autoinhibited unit of the guanine nucleotide exchange factor intersectin. PLoS One. 2010 Jun 24;5(6):e11291. PMID:20585582 doi:10.1371/journal.pone.0011291

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