2cky
From Proteopedia
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| - | [[Image:2cky.gif|left|200px]]<br /><applet load="2cky" size=" | + | [[Image:2cky.gif|left|200px]]<br /><applet load="2cky" size="350" color="white" frame="true" align="right" spinBox="true" |
caption="2cky, resolution 2.90Å" /> | caption="2cky, resolution 2.90Å" /> | ||
'''Structure of the arabidopsis thaliana thiamine pyrophosphate riboswitch with its regulatory ligand'''<br /> | '''Structure of the arabidopsis thaliana thiamine pyrophosphate riboswitch with its regulatory ligand'''<br /> | ||
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==About this Structure== | ==About this Structure== | ||
| - | 2CKY is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/ ] with MG, OS and TPP as [http://en.wikipedia.org/wiki/ligands ligands]. Known structural/functional Site: <scene name='pdbsite=AC1:Tpp Binding Site For Chain B'>AC1</scene>. Full crystallographic information is available from [http:// | + | 2CKY is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/ ] with <scene name='pdbligand=MG:'>MG</scene>, <scene name='pdbligand=OS:'>OS</scene> and <scene name='pdbligand=TPP:'>TPP</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. Known structural/functional Site: <scene name='pdbsite=AC1:Tpp+Binding+Site+For+Chain+B'>AC1</scene>. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CKY OCA]. |
==Reference== | ==Reference== | ||
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[[Category: nucleic acid]] | [[Category: nucleic acid]] | ||
| - | ''Page seeded by [http:// | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Feb 3 10:36:27 2008'' |
Revision as of 08:36, 3 February 2008
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Structure of the arabidopsis thaliana thiamine pyrophosphate riboswitch with its regulatory ligand
Overview
Riboswitches are untranslated regions of messenger RNA, which adopt, alternate structures depending on the binding of specific metabolites., Such conformational switching regulates the expression of proteins, involved in the biosynthesis of riboswitch substrates. Here, we present, the 2.9 angstrom-resolution crystal structure of the eukaryotic, Arabidopsis thaliana thiamine pyrophosphate (TPP)-specific riboswitch in, complex with its natural ligand. The riboswitch specifically recognizes, the TPP via conserved residues located within two highly distorted, parallel "sensor" helices. The structure provides the basis for, understanding the reorganization of the riboswitch fold upon TPP binding, and explains the mechanism of resistance to the antibiotic pyrithiamine.
About this Structure
2CKY is a Single protein structure of sequence from [1] with , and as ligands. Known structural/functional Site: . Full crystallographic information is available from OCA.
Reference
Structure of the eukaryotic thiamine pyrophosphate riboswitch with its regulatory ligand., Thore S, Leibundgut M, Ban N, Science. 2006 May 26;312(5777):1208-11. Epub 2006 May 4. PMID:16675665
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Categories: Single protein | Ban, N. | Leibundgut, M. | Thore, S. | MG | OS | TPP | Nucleic acid
