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Kinesin

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===Kinesin Heavy Chain (KIF)===
===Kinesin Heavy Chain (KIF)===
-
[[3hog]] – SOD – tomato <br />
+
[[2wbe]] – cKIF MD+FNL+Tubulin A+Tubulin B+AMPPNP – cow <br />
-
[[1p7g]] – SOD – Pyrobaculum aerophilum <br />
+
[[1ia0]] – KIF1A MD+Tubulin A+Tubulin B+ATP - pig<br />
 +
[[3gbj]] – hKIF13B MD+ADP – human<br />
 +
[[3edl]] – cKIF MD+ Tubulin A+Tubulin B – EM<br />
 +
[[2zfi]], [[2zfj]], [[2zfk]], [[2zfl]], [[2zfm]] – mKIF1A – mouse<br />
 +
[[1vfv]], [[1vfw]] – mKIF1A MD+Mg-AMPPNP<br />
 +
[[1vfx]] - mKIF1A MD+ADP-Mg-AlFx<br />
 +
[[1vfz]] - mKIF1A MD+ADP-Mg-VO4<br />
 +
[[1v8j]] – mKIF2C MD+Mg-ADP<br />
 +
[[1i5s]] - mKIF2C MD (mutant)+Mg-ADP<br />
 +
[[1i6i]] - mKIF2C MD (mutant)+Mg-AMPPCP<br />
 +
[[1v8k]] - mKIF2C MD+Mg-AMPPNP<br />
 +
[[2p4n]] – hKIF+ Tubulin A+TubulinB – EM docking<br />
 +
[[2vvg]] – KIF2 MD – Giardia intestinalis<br />
 +
[[2cjo]] – hKIF13+inhibitor 30<br />
 +
[[2nr8]] – hKIF9+ADP<br />
 +
[[2g1l]] - hKIF1C FHA domain<br />
 +
[[2owm]] – NcKIF1C MD – Neurospora crassa<br />
 +
[[1goj]] – NcKIF MD<br />
 +
[[3bfn]] – hKIF22 MD<br />
 +
[[3b6u]], [[3b6v]] – hKIF3B MD<br />
 +
[[2rep]] – hKIFC1 MD<br />
 +
[[2eh0]] - hKIF1B FHA domain – NMR<br />
 +
[[2edu]] – hKIF22 C-terminal – NMR<br />
 +
[[2v14]] – hKIF16B<br />
 +
[[2heh]] – hKIF2C<br />
 +
[[2h58]] – hKIFC3+ADP<br />
 +
[[2gry]] – hKIF2+ADP<br />
 +
[[2cow]] – hKIF13B CAP-gly domain – NMR<br />
 +
[[1mkj]] – hKIF MD+docked FNL<br />
 +
[[1bg2]] – hKIF MD<br />
 +
[[3kin]], [[2kin]] – KIF MD - rat<br />
 +
[[2hfx]] – pKIF1A head+AMPPNP – pig<br />
 +
[[2hxh]] - pKIF1A head+ADP<br />
 +
[[1ry6]] – KIF MD – Plasmodium falciparum<br />
 +
[[2ncd]], [[1cz7]] – DmKIF MD non-claret disjuctional (NCD) dimer – Drosophila melanogaster <br />
 +
[[1n6m]] – DmKIF MD+FNL<br />
 +
===Kinesin light chain (KLC)===
 +
[[3edt]] – hKLC2<br />
 +
[[3ceq]] – hKLC2 TPR domain<br />
 +
===Kar3===
-
===Cu-Zn-SOD===
+
[[1f9t]], [[1f9u]], [[1f9v]], [[1f9w]], [[3kar]] - Kar3 MD (mutant) - yeast<br />
-
[[2jlp]], [[2v0a]], [[2c9v]], [[2c9u]], [[2c9s]], [[1pu0]], [[1hl5]], [[1sos]], [[1spd]] - hSOD +Zn+Cu - human<br />
+
===Eg5===
-
[[3h2p]], [[3h2q]], [[3h2r]], [[3hff]], [[3gqf]], [[2nnx]], [[1p1v]], [[1oez]] – hSOD (mutant) +Zn<br />
+
-
[[2af2]], [[1kmg]] - hSOD (mutant) +Zn – NMR<br />
+
-
[[1l3n]], [[1dsw]], [[1ba9]] – hSOD (mutant) +Zn+Cu - NMR<br />
+
-
[[1rk7]] - hSOD (mutant) apo – NMR<br />
+
-
[[1ozt]], [[3gzp]], [[3gzq]], [[3ecv]], [[3ecw]], [[2gbu]] - hSOD (mutant) apo<br />
+
-
[[3ecu]], [[3k91]] – hSOD apo<br />
+
-
[[2r27]] - hSOD +Cu<br />
+
-
[[1hl4]] - hSOD +Zn<br />
+
-
[[2wko]], [[3gzo]],[[ 2zkw]], [[2zkx]], [[2zky]], [[3cqp]], [[3cqq]], [[2vr6]], [[2vr7]], [[2vr8]], [[2gbt]], [[2gbv]], [[1uxl]], [[1uxm]], [[1ptz]], [[1ozu]], [[1n18]], [[1n19]], [[1fun]], [[1mfm]], [[1azv]] – hSOD (mutant) +Zn+Cu<br />
+
-
[[3l9e]] - smSOD +Zn – silk moth<br />
+
-
[[3l9y]] - smSOD +Zn+Cu<br />
+
-
[[2wn0]] – YpSOD+Zn+Cu – Yersinia pseudotuberculosis<br />
+
-
[[2wn1]] - YpSOD+Zn+Cu+N3<br />
+
-
[[2z7u]], [[2z7w]], [[2z7y]], [[2z7z]], [[2aeo]], [[1q0e]], [[1e9p]], [[1e9q]], [[1cb4]], [[1cbj]], [[1sxn]], [[1sxa]], [[1sxb]], [[1sxc]], [[1spd]], [[1sda]], [[3sod]], [[2sod]], [[2zow]], [[3hw7]] – cSOD+Zn+Cu - cow<br />
+
-
[[1cob]] – cSOD+Cu+Co<br />
+
-
[[1sxs]] - cSOD +Zn+Cu+SCN<br />
+
-
[[1sxz]] - cSOD +Zn+Cu+N3<br />
+
-
[[1e9o]] – cSOD+Cu<br />
+
-
[[3f7k]] - ApSOD +Zn+Cu+H2O2 – Alvinella pompejana<br />
+
-
[[3f7l]] - ApSOD +Zn+Cu<br />
+
-
[[2k4w]] – SeSOD (mutant) +Zn+Cu – Salmonella enterica – NMR<br />
+
-
[[1eqw]] - SOD +Zn+Cu – Salmonella typhimurium<br />
+
-
[[3ce1]] - SOD +Zn+Cu – Cryptococcus liquefaciens<br />
+
-
[[2q2l]] - SOD +Zn – Potentilla atrosanguinea<br />
+
-
[[2aqm]] - SOD +Zn+Cu – Brucella abortus<br />
+
-
[[2aps]] - SOD +Zn+Cu – Actinobacillus pleuropneumoniae<br />
+
-
[[2aqn]] - NmSOD +Zn+Cu – Neisseria meningitides<br />
+
-
[[2aqp]], [[2aqq]], [[2aqr]], [[2aqs]], [[2aqt]] – NmSOD (mutant) +Zn+Cu<br />
+
-
[[1z9n]] - HdSOD +Zn+Cu+haem – Haemophilus ducreyi<br />
+
-
[[1z9p]] - HdSOD +Zn+Cu<br />
+
-
[[1to4]], [[1to5]] - SOD +Zn+Cu – Schistosoma mansoni<br />
+
-
[[1pzs]] - MtSOD +Cu – Mycobacterium tuberculosis<br />
+
-
[[1oaj]], [[1bzo]], [[1yai]] - PlSOD +Zn+Cu – Photobacterium leiognathi<br />
+
-
[[1oal]], [[1ib5]], [[1ibb]], [[1ibd]], [[1ibf]], [[1ibh]] – PlSOD (mutant) +Zn+Cu<br />
+
-
[[1f18]], [[1f1a]], [[1f1d]], [[1b4t]] – ySOD (mutant) +Zn+Cu – yeast<br />
+
-
[[1f1g]], [[1b4l]], [[2jcw]], [[1sdy]] - ySOD +Zn+Cu<br />
+
-
[[1yaz]] - ySOD +Zn+Cu+N3<br />
+
-
[[1jk9]] – ySOD+Zn+Cu chaperone for SOD<br />
+
-
[[1eso]] - EcSOD +Zn+Cu - Escherichia coli<br />
+
-
[[1yso]] - EcSOD +Zn+Cu<br />
+
-
[[1srd]] – SOD+MZn+Cu –Spinach<br />
+
 +
[[3ken]] - hKIF11 MD+S-trityl-L-cysteine
 +
[[2q2y]], [[2fky]], [[2q2z]], [[2g1q]], [[2fl2]], [[2fl6]], [[1yrs]] - hKIF11+inhibitors<br />
 +
[[2pg2]] - hKIF11+inhibitor 15+ADP<br />
 +
[[2uyi]] - hKIF11+inhibitor 33+ADP<br />
 +
[[2uym]] - hKIF11+inhibitor 37+ADP<br />
 +
[[2ieh]] - hKIF11+inhibitor (R)-mon97<br />
 +
[[2fme]], [[3l9h]] - hKIF11+quinoline inhibitor<br />
 +
[[1x88]], [[1q0b]] - hKIF11 MD+MgADP+monastrol <br />
 +
[[3k3b]] - hKIF11 MD+tetrahydro-beta-carboline<br />
 +
[[3hqd]] - hKIF11 MD+AMPPNP+Mg<br />
 +
[[1ii6]] - hKIF11 MD+ADP+Mg<br />
 +
[[3k5e]] - hKIF11 MD+ADP+enastrol<br />
-
===Mn-SOD===
+
===KCBP===
-
[[3k9s]] – EcSOD+H2O2 <br />
+
-
[[1d5n]], [[1vew]] - EcSOD+Mn<br />
+
-
[[1mmm]] – EcSOD+Fe<br />
+
-
[[1zlz]], [[1ixb]], [[1ix9]], [[1en4]], [[1en5]], [[1en6]], [[1i08]], [[1i0h]] – EcSOD (mutant)+Mn<br />
+
-
[[3dc5]], [[3dc6]] – SOD+Mn – Caenorhabditis elegans<br />
+
-
[[3bfr]], [[1jcv]] – ySOD+Mn <br />
+
-
[[2qka]], [[2adp]], [[2adq]], [[1xdc]], [[1xil]], [[1n0j]], [[1luv]], [[1msd]] – hSOD+Mn<br />
+
-
[[2qkc]], [[3c3s]], [[3c3t]], [[2p4k]], [[1zsp]], [[1zte]], [[1zuq]], [[2gds]], [[1szx]], [[1pl4]], [[1pm9]], [[1n0n]], [[1luw]], [[1ja8]], [[1em1]], [[1ap5]], [[1ap6]], [[1qnm]], [[1var]] – hSOD (mutant)+Mn<br />
+
-
[[2rcv]] – SOD+Mn – Bacillus subtilis<br />
+
-
[[1xre]], [[1xuq]] – SOD+Mn – Bacillus anthracis<br />
+
-
[[2aw9]], [[2cdy]], [[2ce4]] – DrSOD+Mn – Deinococcus radiodurans<br />
+
-
[[1y67]] – DrSOD+Fe<br />
+
-
[[2a03]] – SOD+Mn+Zn – Plasmodium berghei<br />
+
-
[[1jr9]] - SOD +Zn+Mn – Virgibacillus halodenitrificans<br />
+
-
[[1gv3]] – SOD+Mn – Anabaena<br />
+
-
[[1kkc]] – SOD+Mn – Aspergillus fumigatus<br />
+
-
[[1xso]] – SOD+Mn – Xenopus laevis<br />
+
-
[[1mng]], [[3mds]] – TtSOD+Mn – Thermus thermophilus<br />
+
 +
[[3h4s]] – KCBP+ADP+Mg – Arabidopsis thaliana<br />
-
===Fe-SOD===
+
===NOD===
-
[[3js4]] – SOD+Fe – Anaplasma phagocytuphilum<br />
+
-
[[3evk]] – SOD+Mn – Pyrobaculum aerophilum<br />
+
-
[[3esf]] – SOD (mutant)+Fe – Trypanosoma brucei<br />
+
-
[[2gpc]] – SOD+Fe – Trypanosoma cruzi<br />
+
-
[[3h1s]] – SOD+Fe – Francisella tularensis<br />
+
-
[[2w7w]] – SOD+Fe – Aliivibrio salmonicida<br />
+
-
[[3cei]] – SOD+Fe – Helicobacter pylori<br />
+
-
[[2goj]], [[2bpi]] – PfSOD+Fe – Plasmodium falciparum<br />
+
-
[[2awp]] – SOD+ion – Plasmodium knowlesi<br />
+
-
[[2bkb]], [[2nyb]], [[1za5]] – EcSOD (mutant)+Fe<br />
+
-
[[2cw2]], [[2cw3]] – SOD+Fe – Perkinsus marinus<br />
+
-
[[1wb7]], [[1wb8]] – SOD (mutant)+Fe – Sulfolobus solfataricus<br />
+
-
[[1unf]] – SOD+Fe – Vigna unguiculata<br />
+
-
[[1uer]], [[1ues]], [[1qnn]] – SOD+Fe – Porphyromonas gingivalis<br />
+
-
[[1my6]] – SOD+Fe – Thermosynechococcus elongates<br />
+
-
[[1ma1]] – SOD+Fe – Methanothermobacter thermautotrophicus<br />
+
-
[[1gn2]], [[1gn3]], [[1gn4]], [[1gn6]] – MtSOD (mutant)+Fe<br />
+
-
[[1ids]] – MtSOD+Fe<br />
+
-
[[1dt0]], [[3sdp]] – SOD+Fe – Pseudomonas putida<br />
+
-
[[1b06]] – SOD+Fe – Sulfolobus acidocaldarius<br />
+
-
[[1bs3]] – PfSOD+Fe+F – Propionibacterium freudenreichii<br />
+
-
[[1bsm]], [[1bt8]] – PfSOD+Fe<br />
+
-
[[1ar4]], [[1ar5]] – PfSOD+Mn<br />
+
-
[[1avm]] – PfSOD+Fe+N3<br />
+
-
[[1coj]] – SOD+Fe – Aquifex pyrophilus<br />
+
-
[[1isa]], [[1isb]], [[1isc]] – EcSOD+Fe <br />
+
-
 
+
[[3dc4]] – DmNOD catalytic core domain+ADP<br />
-
===Ni-SOD===
+
[[3dcb]] - DmNOD catalytic core domain+AMPPNP<br />
-
[[3g4x]], [[3g4z]], [[3g50]], [[1t6u]] – ScSOD (mutant)+Ni – Streptomyces coelicolor<br />
+
[[3dco]] - DmNOD catalytic core domain+ cTubulin A+cTubulin B<br />
-
[[1t6i]], [[1t6q]] – ScSOD apo <br />
+
-
[[1q0d]], [[1q0f]], [[1q0g]], [[1q0k]], [[1q0m]] – SOD+Ni – Streptomyces seoulensis<br />
+

Revision as of 10:14, 22 July 2010

Image:Kif1A Motor Domain.jpg

Kinesin

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3D Structure of Kinesin

Contents

Kinesin

Kinesins are eukaryotic motor proteins which move along microtubules. Kinesin (KIF) is a dimer consisting of 2 heavy chains and two light chains. The heavy chain contains the globular motor domain (MD), flexible neck linker (FNL) and a long coiled-coil stalk which intertwines to form the dimer. The light chain (KLC) forms the tail region. The KLC contains a cargo binding domain which is called TPR (Tetratricopeptide repeat). The KIFs are named by their gene number. KIF contains a forkhead-associated domain (FHA) which is involved in phosphopeptide recognition. Kinesin protein in yeast is called Kar3. Eg5 or KIF11 is a kinesin which participates in mitosis. KCBP is a Kinesin-like Calmodulin Binding Protein. NOD is a Drosophila chromosome-associated kinesin.


3D Structures of Kinesin

Kinesin Heavy Chain (KIF)

2wbe – cKIF MD+FNL+Tubulin A+Tubulin B+AMPPNP – cow
1ia0 – KIF1A MD+Tubulin A+Tubulin B+ATP - pig
3gbj – hKIF13B MD+ADP – human
3edl – cKIF MD+ Tubulin A+Tubulin B – EM
2zfi, 2zfj, 2zfk, 2zfl, 2zfm – mKIF1A – mouse
1vfv, 1vfw – mKIF1A MD+Mg-AMPPNP
1vfx - mKIF1A MD+ADP-Mg-AlFx
1vfz - mKIF1A MD+ADP-Mg-VO4
1v8j – mKIF2C MD+Mg-ADP
1i5s - mKIF2C MD (mutant)+Mg-ADP
1i6i - mKIF2C MD (mutant)+Mg-AMPPCP
1v8k - mKIF2C MD+Mg-AMPPNP
2p4n – hKIF+ Tubulin A+TubulinB – EM docking
2vvg – KIF2 MD – Giardia intestinalis
2cjo – hKIF13+inhibitor 30
2nr8 – hKIF9+ADP
2g1l - hKIF1C FHA domain
2owm – NcKIF1C MD – Neurospora crassa
1goj – NcKIF MD
3bfn – hKIF22 MD
3b6u, 3b6v – hKIF3B MD
2rep – hKIFC1 MD
2eh0 - hKIF1B FHA domain – NMR
2edu – hKIF22 C-terminal – NMR
2v14 – hKIF16B
2heh – hKIF2C
2h58 – hKIFC3+ADP
2gry – hKIF2+ADP
2cow – hKIF13B CAP-gly domain – NMR
1mkj – hKIF MD+docked FNL
1bg2 – hKIF MD
3kin, 2kin – KIF MD - rat
2hfx – pKIF1A head+AMPPNP – pig
2hxh - pKIF1A head+ADP
1ry6 – KIF MD – Plasmodium falciparum
2ncd, 1cz7 – DmKIF MD non-claret disjuctional (NCD) dimer – Drosophila melanogaster
1n6m – DmKIF MD+FNL

Kinesin light chain (KLC)

3edt – hKLC2
3ceq – hKLC2 TPR domain

Kar3

1f9t, 1f9u, 1f9v, 1f9w, 3kar - Kar3 MD (mutant) - yeast

Eg5

3ken - hKIF11 MD+S-trityl-L-cysteine 2q2y, 2fky, 2q2z, 2g1q, 2fl2, 2fl6, 1yrs - hKIF11+inhibitors
2pg2 - hKIF11+inhibitor 15+ADP
2uyi - hKIF11+inhibitor 33+ADP
2uym - hKIF11+inhibitor 37+ADP
2ieh - hKIF11+inhibitor (R)-mon97
2fme, 3l9h - hKIF11+quinoline inhibitor
1x88, 1q0b - hKIF11 MD+MgADP+monastrol
3k3b - hKIF11 MD+tetrahydro-beta-carboline
3hqd - hKIF11 MD+AMPPNP+Mg
1ii6 - hKIF11 MD+ADP+Mg
3k5e - hKIF11 MD+ADP+enastrol

KCBP

3h4s – KCBP+ADP+Mg – Arabidopsis thaliana

NOD

3dc4 – DmNOD catalytic core domain+ADP
3dcb - DmNOD catalytic core domain+AMPPNP
3dco - DmNOD catalytic core domain+ cTubulin A+cTubulin B

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