Ferritin

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Line 13: Line 13:
[[2jd8]] – PfFR+Zn<br />
[[2jd8]] – PfFR+Zn<br />
[[3kxu]] – hFR (mutant) – human<br />
[[3kxu]] – hFR (mutant) – human<br />
-
[[3hx2]], [[3hx5]], [[3hx7]] - hFR<br />
+
[[3hx2]], [[3hx5]], [[3hx7]], [[1fha]] - hFR<br />
[[3a68]] – soFR from gene SferH4 – soybean<br />
[[3a68]] – soFR from gene SferH4 – soybean<br />
[[3a9q]] - soFR from gene SferH4 (mutant) <br />
[[3a9q]] - soFR from gene SferH4 (mutant) <br />
Line 23: Line 23:
[[1eum]] - EcFR – ''Escherichia coli''<br />
[[1eum]] - EcFR – ''Escherichia coli''<br />
[[1qgh]] – LiFR - ''Listeria innocua''<br />
[[1qgh]] – LiFR - ''Listeria innocua''<br />
-
[[1mfr]], [[1bg7]] – bFR - Bullfrog<br />
+
[[1mfr]], [[1bg7]], [[3ka3]], [[3ka4]] – bFR - Bullfrog<br />
 +
[[3ka6]], [[3ka8]], [[3ka9]] – bFR (mutant)+Co
===Ferritin light chain (FTL) ===
===Ferritin light chain (FTL) ===
Line 33: Line 34:
===Ferritin heavy chain (FTH) ===
===Ferritin heavy chain (FTH) ===
-
[[2z6m]], [[1r03]], [[2fha]] – hFTH<br />
+
[[2z6m]], [[1r03]], [[2fha]], [[3ajo]] – hFTH<br />
 +
[[3ajp]], [[3ajq]] - hFTH (mutant)<br />
[[2z6o]] – FTH – ''Trichoplusia ni''<br />
[[2z6o]] – FTH – ''Trichoplusia ni''<br />
Line 47: Line 49:
===apo-ferritin light chain (apo-FTL) ===
===apo-ferritin light chain (apo-FTL) ===
-
[[2zg7]], [[2z5p]], [[2z5q]], [[2z5r]], [[3fi6]] – apo-hoFTL+Pd<br />
+
[[2zg7]], [[2z5p]], [[2z5q]], [[2z5r]], [[3fi6]], [[3af7]] – apo-hoFTL+Pd<br />
-
[[2zg8]], [[2zg9]] - apo-hoFTL (mutant)+Pd<br />
+
[[2zg8]], [[2zg9]], [[3af8]], [[3af9]] - apo-hoFTL (mutant)+Pd<br />
[[3f33]], [[3f34]], [[3f35]], [[3f36]], [[3f37]], [[3f38]], [[3f39]] - apo-hoFTL+phenols<br />
[[3f33]], [[3f34]], [[3f35]], [[3f36]], [[3f37]], [[3f38]], [[3f39]] - apo-hoFTL+phenols<br />
[[2v2i]], [[2v2j]] - apo-hoFTL+haemin<br />
[[2v2i]], [[2v2j]] - apo-hoFTL+haemin<br />
Line 55: Line 57:
[[1xz3]] - apo-hoFTL+isoflurane<br />
[[1xz3]] - apo-hoFTL+isoflurane<br />
[[1gwg]] - apo-hoFTL+I3<br />
[[1gwg]] - apo-hoFTL+I3<br />
-
[[2w0o]] – apo-hoFTL<br />
 
[[2v2l]], [[2v2m]], [[2v2n]], [[2v2o]], [[2v2p]], [[2v2r]], [[2v2s]] - apo-hoFTL (mutant)+haemin<br />
[[2v2l]], [[2v2m]], [[2v2n]], [[2v2o]], [[2v2p]], [[2v2r]], [[2v2s]] - apo-hoFTL (mutant)+haemin<br />
-
[[2za6]], [[2g4h]], [[1aew]], [[1dat]], [[1ier]], [[1ies]], [[3f32]], [[2zur]] - apo-hoFTL<br />
+
[[2za6]], [[2g4h]], [[1aew]], [[1dat]], [[1ier]], [[1ies]], [[3f32]], [[2zur]], [[2w0o]] - apo-hoFTL<br />
[[2ffx]], [[2fg4]], [[2fg8]] – apo-hFTL<br />
[[2ffx]], [[2fg4]], [[2fg8]] – apo-hFTL<br />
Line 70: Line 71:
[[3gvy]] – BFR – ''Rhodobacter sphaeroides''<br />
[[3gvy]] – BFR – ''Rhodobacter sphaeroides''<br />
 +
[[1jgc]] - BFR – ''Rhodobacter capsulatus''<br />
 +
[[1ji4]] – BFR – ''Helicobacter pylori''<br />
 +
[[1nf4]], [[1nf6]], [[1nfv]] – BFR – ''Desulfovibrio desulfuricans''<br />
[[3fvb]] – BmBFR - ''Brucelia melitensis''<br />
[[3fvb]] – BmBFR - ''Brucelia melitensis''<br />
-
[[2fkz]], [[2fl0]] – BFR – ''Azotobacrter vinelandii''<br />
+
[[2fkz]], [[2fl0]], [[1sof]] – BFR – ''Azotobacrter vinelandii''<br />
-
[[1bfr]] – EcBFR <br />
+
[[2wtl]] – BFR – ''Mycobacterium tuberculosis''<br />
 +
[[3bkn]] - BFR – ''Mycobacterium smegmatis''<br />
 +
[[3is7]], [[3is8]], [[3ise]], [[3isf]] – BFR – ''Pseudomonas aeruginosa''<br />
 +
[[1bfr]], [[1bcf]], [[2htn]], [[2vxi]], [[3e1j]], [[3e1l]], [[3e1m]], [[3e1n]], [[3e1p]], [[3e1o]], [[3e1q]] – EcBFR <br />
 +
[[3e2c]], [[3ghq]] – EcBFR (mutant)
===Thioferritin (TFR) ===
===Thioferritin (TFR) ===
Line 85: Line 93:
[[2bkc]], [[2bk6]], [[2bjy]] – LiDps (mutant) <br />
[[2bkc]], [[2bk6]], [[2bjy]] – LiDps (mutant) <br />
[[2f7n]] – Dps – ''Deinococcus radiodurans''<br />
[[2f7n]] – Dps – ''Deinococcus radiodurans''<br />
-
[[1tjo]], [[1tk6]], [[1tkp]], [[1moj]] – Dps – ''Halobacterium salinarum''<br />
+
[[1tjo]], [[1tk6]], [[1tkp]], [[1tko]], [[1moj]] – Dps – ''Halobacterium salinarum''<br />
[[1o9r]] – Dps – ''Agrobacterium tumefaciens''<br />
[[1o9r]] – Dps – ''Agrobacterium tumefaciens''<br />
[[1dps]] – EcDps <br />
[[1dps]] – EcDps <br />

Revision as of 09:54, 21 December 2010

Image:2jd73.png
Crystal structure of ferritin from Pyrococcs Furiousus (2jd7)

Crystal structure of Fe-soaked ferritin from the hyperthermophilic archael anaerobe Pyrococcus furiousus, 2jd7

Drag the structure with the mouse to rotate

Ferritin (FR) is an iron storage and release protein. It stores iron as microcrystals with phosphate and hydroxide ions. FR is composed of 24 subunits of heavy chain (FTH) and light chain (FTL). Bacterioferritin (BFR) structure is very similar to FR. It contains a binuclear iron center and haem. It stores iron as ferric oxide mineral in its hollow central cavity. Thioferritin (TFR) is a ferritin-related protein with 2 Cysteine residues adjacent to the dimetal binding site. Another iron storing protein is the DNA-binding Protein of Starved cells (Dps). MrgA – another iron storage protein - belongs to the Dps family.

Contents

3D Structures of Ferritin

Ferritin

2jd6, 2jd7 – PfFR - Pyrococcus furiosus
2jd8 – PfFR+Zn
3kxu – hFR (mutant) – human
3hx2, 3hx5, 3hx7, 1fha - hFR
3a68 – soFR from gene SferH4 – soybean
3a9q - soFR from gene SferH4 (mutant)
3egm, 3bvf, 3bvi, 3bvk, 3bvl – HpFR – Heliobacter pylori
3e6s - PnFR – Pseudo-nitzschia
1z4a, 1vlg – FR – Thermotoga maritime
1s3q, 1sq3 – FR – Archaeoglubus fulgidus
1krq – FR – Campylobacter jejuni
1eum - EcFR – Escherichia coli
1qgh – LiFR - Listeria innocua
1mfr, 1bg7, 3ka3, 3ka4 – bFR - Bullfrog
3ka6, 3ka8, 3ka9 – bFR (mutant)+Co

Ferritin light chain (FTL)

1lb3, 1h96 – FTL – mouse
1rcc, 1rcd, 1rci – bFTL+tartrate+Mg
1rce, 1rcg - bFTL+tartrate+Mn

Ferritin heavy chain (FTH)

2z6m, 1r03, 2fha, 3ajo – hFTH
3ajp, 3ajq - hFTH (mutant)
2z6o – FTH – Trichoplusia ni

apo-ferritin (apo-FR)

2x17 – apo-PfFR+Ag
3h7g – apo-hoFR+Au – horse
1hrs - apo-hoFR+protoporphyrin
3bve – apo-HpFR
3e6r – apo-PnFR
2clu, 2cn6 - apo-hFR (mutant)+Zn

apo-ferritin light chain (apo-FTL)

2zg7, 2z5p, 2z5q, 2z5r, 3fi6, 3af7 – apo-hoFTL+Pd
2zg8, 2zg9, 3af8, 3af9 - apo-hoFTL (mutant)+Pd
3f33, 3f34, 3f35, 3f36, 3f37, 3f38, 3f39 - apo-hoFTL+phenols
2v2i, 2v2j - apo-hoFTL+haemin
2gyd - apo-hoFTL+diaziflurane
1xz1 - apo-hoFTL+halothane
1xz3 - apo-hoFTL+isoflurane
1gwg - apo-hoFTL+I3
2v2l, 2v2m, 2v2n, 2v2o, 2v2p, 2v2r, 2v2s - apo-hoFTL (mutant)+haemin
2za6, 2g4h, 1aew, 1dat, 1ier, 1ies, 3f32, 2zur, 2w0o - apo-hoFTL
2ffx, 2fg4, 2fg8 – apo-hFTL

apo-ferritin heavy chain (apo-FTH)

2za7, 2za8, 2cn7, 2chi, 2clu - apo-hoFTH (mutant)
2cei, 2cih, 2cn6, 2iu2 - apo-hoFTH (mutant)+Zn
3erz – apo-hFR+Hg
3es3 - apo-hFR+Au

Bacterioferritin (BFR)

3gvy – BFR – Rhodobacter sphaeroides
1jgc - BFR – Rhodobacter capsulatus
1ji4 – BFR – Helicobacter pylori
1nf4, 1nf6, 1nfv – BFR – Desulfovibrio desulfuricans
3fvb – BmBFR - Brucelia melitensis
2fkz, 2fl0, 1sof – BFR – Azotobacrter vinelandii
2wtl – BFR – Mycobacterium tuberculosis
3bkn - BFR – Mycobacterium smegmatis
3is7, 3is8, 3ise, 3isf – BFR – Pseudomonas aeruginosa
1bfr, 1bcf, 2htn, 2vxi, 3e1j, 3e1l, 3e1m, 3e1n, 3e1p, 3e1o, 3e1q – EcBFR
3e2c, 3ghq – EcBFR (mutant)

Thioferritin (TFR)

2vzb – TFR – Bacterioides fragilis

DNA-binding Protein of Starved cells (Dps)

3iq1 – Dps – Vibrio cholerae
3ge4 – BmDps
2iy4 – Dps – Listeria monocytogenes
2bkc, 2bk6, 2bjy – LiDps (mutant)
2f7n – Dps – Deinococcus radiodurans
1tjo, 1tk6, 1tkp, 1tko, 1moj – Dps – Halobacterium salinarum
1o9r – Dps – Agrobacterium tumefaciens
1dps – EcDps

MrgA

2chp – MrgA – Bacillus subtilis

Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Joel L. Sussman, David Canner, Eran Hodis, Alexander Berchansky

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