Gyrase

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===Gyrase Subunit A===
===Gyrase Subunit A===
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[[3l6v]] – GyrA C-terminal – Xanthomonas campestris <br />
+
[[3l6v]] – GyrA C-terminal – ''Xanthomonas campestris'' <br />
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[[2wl2]] – EcGyrA N-terminal+simocylinone – Escherichia coli<br />
+
[[2wl2]] – EcGyrA N-terminal+simocylinone – ''Escherichia coli''<br />
[[1ajb]] - EcGyrA N-terminal+novobiocin<br />
[[1ajb]] - EcGyrA N-terminal+novobiocin<br />
[[1zi0]], [[1ab4]] - EcGyrA C-terminal<br />
[[1zi0]], [[1ab4]] - EcGyrA C-terminal<br />
[[1x75]] – EcGyrA14+CcdB<br />
[[1x75]] – EcGyrA14+CcdB<br />
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[[3ilw]] - MtGyrA N-terminal – Mycobacterium tuberculosis<br />
+
[[3ilw]] - MtGyrA N-terminal – ''Mycobacterium tuberculosis''<br />
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[[1suu]] - GyrA C-terminal – Borrelia burgdorferi<br />
+
[[1suu]] - GyrA C-terminal – ''Borrelia burgdorferi''<br />
===Gyrase Subunit B===
===Gyrase Subunit B===

Revision as of 06:15, 26 July 2010

Image:3L6V.jpg
Crystal Structure of Xanthomonas campestris Gyrase A C-terminal Domain, 3l6v

Crystal Structure of the Xanthomonas campestris Gyrase A C-terminal Domain, 3l6v

Drag the structure with the mouse to rotate

Gyrase (Gyr) is a type of topoisomerase II in prokaryotes which unwinds double stranded DNA. The DNA Gyr cutting allows the formation of a negative DNA supercoil which enables replication of DNA. Gyr consists of 2 subunits: GyrA and GyrB. Reverse gyrase (Top-RG) is a type of topoisomerase I which catalyses the formation of positive DNA supercoil.

Contents

3D Structure of Gyrase

Gyrase Subunit A

3l6v – GyrA C-terminal – Xanthomonas campestris
2wl2 – EcGyrA N-terminal+simocylinone – Escherichia coli
1ajb - EcGyrA N-terminal+novobiocin
1zi0, 1ab4 - EcGyrA C-terminal
1x75 – EcGyrA14+CcdB
3ilw - MtGyrA N-terminal – Mycobacterium tuberculosis
1suu - GyrA C-terminal – Borrelia burgdorferi

Gyrase Subunit B

3g75, 3g7b, 3g7e – GyrB+thiazole inhibitor – Staphylococcus aureus
2cjt - MtGyrB C-terminal
3cwv – GyrB truncated – Myxococcus xanthus
1kzn, 1ei1 - EcGyrB N-terminal+clorobiocin
1kij – GyrB domain+novobiocin – Thermus thermophilus

Reverse Gyrase

1gku – AfTop-RG – Archaeoglobus fulgidus
1gl9 - AfTop-RG+ADPNP

Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Alexander Berchansky, David Canner, Joel L. Sussman

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