2iuu
From Proteopedia
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| - | [[Image:2iuu.gif|left|200px]]<br /><applet load="2iuu" size=" | + | [[Image:2iuu.gif|left|200px]]<br /><applet load="2iuu" size="350" color="white" frame="true" align="right" spinBox="true" |
caption="2iuu, resolution 2.9Å" /> | caption="2iuu, resolution 2.9Å" /> | ||
'''P. AERUGINOSA FTSK MOTOR DOMAIN, HEXAMER'''<br /> | '''P. AERUGINOSA FTSK MOTOR DOMAIN, HEXAMER'''<br /> | ||
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==About this Structure== | ==About this Structure== | ||
| - | 2IUU is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Pseudomonas_aeruginosa Pseudomonas aeruginosa] with ADP as [http://en.wikipedia.org/wiki/ligand ligand]. Known structural/functional Site: <scene name='pdbsite=AC1:Adp Binding Site For Chain F'>AC1</scene>. Full crystallographic information is available from [http:// | + | 2IUU is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Pseudomonas_aeruginosa Pseudomonas aeruginosa] with <scene name='pdbligand=ADP:'>ADP</scene> as [http://en.wikipedia.org/wiki/ligand ligand]. Known structural/functional Site: <scene name='pdbsite=AC1:Adp+Binding+Site+For+Chain+F'>AC1</scene>. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2IUU OCA]. |
==Reference== | ==Reference== | ||
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[[Category: transmembrane]] | [[Category: transmembrane]] | ||
| - | ''Page seeded by [http:// | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Feb 3 10:38:27 2008'' |
Revision as of 08:38, 3 February 2008
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P. AERUGINOSA FTSK MOTOR DOMAIN, HEXAMER
Overview
FtsK is a DNA translocase that coordinates chromosome segregation and cell, division in bacteria. In addition to its role as activator of XerCD, site-specific recombination, FtsK can translocate double-stranded DNA, (dsDNA) rapidly and directionally and reverse direction. We present, crystal structures of the FtsK motor domain monomer, showing that it has a, RecA-like core, the FtsK hexamer, and also showing that it is a ring with, a large central annulus and a dodecamer consisting of two hexamers, head, to head. Electron microscopy (EM) demonstrates the DNA-dependent existence, of hexamers in solution and shows that duplex DNA passes through the, middle of each ring. Comparison of FtsK monomer structures from two, different crystal forms highlights a conformational change that we propose, is the structural basis for a rotary inchworm mechanism of DNA, translocation.
About this Structure
2IUU is a Single protein structure of sequence from Pseudomonas aeruginosa with as ligand. Known structural/functional Site: . Full crystallographic information is available from OCA.
Reference
Double-stranded DNA translocation: structure and mechanism of hexameric FtsK., Massey TH, Mercogliano CP, Yates J, Sherratt DJ, Lowe J, Mol Cell. 2006 Aug;23(4):457-69. PMID:16916635
Page seeded by OCA on Sun Feb 3 10:38:27 2008
Categories: Pseudomonas aeruginosa | Single protein | Lowe, J. | Massey, T.H. | Mercogliano, C.P. | Sherratt, D.J. | Yates, J. | ADP | Aaa atpase | Atp-binding | Cell cycle | Cell division | Chromosome partition | Divisome | Dna translocation | Dna-binding | Hexameric ring | Inner membrane | Kops | Membrane | Membrane protein | Nucleotide-binding | Transmembrane
