3mdr

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===Tranylcypromine complex of Cytochrome P450 46A1===
===Tranylcypromine complex of Cytochrome P450 46A1===
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{{ABSTRACT_PUBMED_20667828}}
==About this Structure==
==About this Structure==
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==Reference==
==Reference==
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<ref group="xtra">PMID:18621681</ref><references group="xtra"/>
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<ref group="xtra">PMID:20667828</ref><ref group="xtra">PMID:18621681</ref><references group="xtra"/>
[[Category: Cholesterol 24-hydroxylase]]
[[Category: Cholesterol 24-hydroxylase]]
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Tranylcypromine]]
[[Category: Tranylcypromine]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jul 28 12:38:26 2010''
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Revision as of 07:04, 13 October 2010

Image:3mdr.png

Template:STRUCTURE 3mdr

Tranylcypromine complex of Cytochrome P450 46A1

Template:ABSTRACT PUBMED 20667828

About this Structure

3MDR is a 2 chains structure with sequences from Homo sapiens. Full crystallographic information is available from OCA.

Reference

  • Mast N, Charvet C, Pikuleva IA, Stout CD. Structural basis of drug binding to CYP46A1, an enzyme that controls cholesterol turnover in the brain. J Biol Chem. 2010 Oct 8;285(41):31783-95. Epub 2010 Jul 28. PMID:20667828 doi:10.1074/jbc.M110.143313
  • Mast N, White MA, Bjorkhem I, Johnson EF, Stout CD, Pikuleva IA. Crystal structures of substrate-bound and substrate-free cytochrome P450 46A1, the principal cholesterol hydroxylase in the brain. Proc Natl Acad Sci U S A. 2008 Jul 15;105(28):9546-51. Epub 2008 Jul 9. PMID:18621681

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