2j2u

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[[Image:2j2u.jpg|left|200px]]<br /><applet load="2j2u" size="450" color="white" frame="true" align="right" spinBox="true"
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[[Image:2j2u.jpg|left|200px]]<br /><applet load="2j2u" size="350" color="white" frame="true" align="right" spinBox="true"
caption="2j2u, resolution 1.90&Aring;" />
caption="2j2u, resolution 1.90&Aring;" />
'''CRYSTAL STRUCTURE OF A HUMAN FACTOR XA INHIBITOR COMPLEX'''<br />
'''CRYSTAL STRUCTURE OF A HUMAN FACTOR XA INHIBITOR COMPLEX'''<br />
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==About this Structure==
==About this Structure==
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2J2U is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with GSQ as [http://en.wikipedia.org/wiki/ligand ligand]. Active as [http://en.wikipedia.org/wiki/Coagulation_factor_Xa Coagulation factor Xa], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.21.6 3.4.21.6] Known structural/functional Site: <scene name='pdbsite=AC1:Gsq Binding Site For Chain A'>AC1</scene>. Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=2J2U OCA].
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2J2U is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with <scene name='pdbligand=GSQ:'>GSQ</scene> as [http://en.wikipedia.org/wiki/ligand ligand]. Active as [http://en.wikipedia.org/wiki/Coagulation_factor_Xa Coagulation factor Xa], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.21.6 3.4.21.6] Known structural/functional Site: <scene name='pdbsite=AC1:Gsq+Binding+Site+For+Chain+A'>AC1</scene>. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2J2U OCA].
==Reference==
==Reference==
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[[Category: zymogen]]
[[Category: zymogen]]
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''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Tue Dec 18 19:46:04 2007''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Feb 3 10:40:57 2008''

Revision as of 08:40, 3 February 2008

Image:2j2u.jpg

2j2u, resolution 1.90Å

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CRYSTAL STRUCTURE OF A HUMAN FACTOR XA INHIBITOR COMPLEX

Contents

Overview

Torsional scans of sulfonamide S-C bonds in small model systems of a, series of arylsulfonamide factor Xa inhibitors were performed in order to, investigate if conformational effects can help to rationalise the observed, SAR. Computational results were in good agreement with the experimental, data indicating that the sulfonamide conformation plays an important role, in determining the activity in this particular series of factor Xa, inhibitors.

Disease

Known disease associated with this structure: Factor X deficiency OMIM:[227600]

About this Structure

2J2U is a Protein complex structure of sequences from Homo sapiens with as ligand. Active as Coagulation factor Xa, with EC number 3.4.21.6 Known structural/functional Site: . Full crystallographic information is available from OCA.

Reference

Arylsulfonamides: a study of the relationship between activity and conformational preferences for a series of factor Xa inhibitors., Senger S, Convery MA, Chan C, Watson NS, Bioorg Med Chem Lett. 2006 Nov 15;16(22):5731-5. Epub 2006 Sep 18. PMID:16982192

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