3mdb
From Proteopedia
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===Crystal structure of the ternary complex of full length centaurin alpha-1, KIF13B FHA domain, and IP4=== | ===Crystal structure of the ternary complex of full length centaurin alpha-1, KIF13B FHA domain, and IP4=== | ||
| + | ==Function== | ||
| + | [[http://www.uniprot.org/uniprot/KI13B_HUMAN KI13B_HUMAN]] Involved in reorganization of the cortical cytoskeleton. Regulates axon formation by promoting the formation of extra axons. May be functionally important for the intracellular trafficking of MAGUKs and associated protein complexes.<ref>PMID:20194617</ref> [[http://www.uniprot.org/uniprot/ADAP1_HUMAN ADAP1_HUMAN]] GTPase-activating protein for the ADP ribosylation factor family (Probable). Binds phosphatidylinositol 3,4,5-trisphosphate (PtdInsP3) and inositol 1,3,4,5-tetrakisphosphate (InsP4).<ref>PMID:10448098</ref> <ref>PMID:10333475</ref> | ||
==About this Structure== | ==About this Structure== | ||
| - | + | [[3mdb]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3MDB OCA]. | |
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| + | ==Reference== | ||
| + | <references group="xtra"/><references/> | ||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
[[Category: Arrowsmith, C H.]] | [[Category: Arrowsmith, C H.]] | ||
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[[Category: Transport protein-hydrolase activator complex]] | [[Category: Transport protein-hydrolase activator complex]] | ||
[[Category: Zinc-finger]] | [[Category: Zinc-finger]] | ||
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| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Aug 4 09:09:47 2010'' | ||
Revision as of 23:21, 10 April 2013
Contents |
Crystal structure of the ternary complex of full length centaurin alpha-1, KIF13B FHA domain, and IP4
Function
[KI13B_HUMAN] Involved in reorganization of the cortical cytoskeleton. Regulates axon formation by promoting the formation of extra axons. May be functionally important for the intracellular trafficking of MAGUKs and associated protein complexes.[1] [ADAP1_HUMAN] GTPase-activating protein for the ADP ribosylation factor family (Probable). Binds phosphatidylinositol 3,4,5-trisphosphate (PtdInsP3) and inositol 1,3,4,5-tetrakisphosphate (InsP4).[2] [3]
About this Structure
3mdb is a 4 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA.
Reference
- ↑ Yoshimura Y, Terabayashi T, Miki H. Par1b/MARK2 phosphorylates kinesin-like motor protein GAKIN/KIF13B to regulate axon formation. Mol Cell Biol. 2010 May;30(9):2206-19. doi: 10.1128/MCB.01181-09. Epub 2010 Mar, 1. PMID:20194617 doi:10.1128/MCB.01181-09
- ↑ Venkateswarlu K, Cullen PJ. Molecular cloning and functional characterization of a human homologue of centaurin-alpha. Biochem Biophys Res Commun. 1999 Aug 19;262(1):237-44. PMID:10448098 doi:10.1006/bbrc.1999.1065
- ↑ Venkateswarlu K, Oatey PB, Tavare JM, Jackson TR, Cullen PJ. Identification of centaurin-alpha1 as a potential in vivo phosphatidylinositol 3,4,5-trisphosphate-binding protein that is functionally homologous to the yeast ADP-ribosylation factor (ARF) GTPase-activating protein, Gcs1. Biochem J. 1999 Jun 1;340 ( Pt 2):359-63. PMID:10333475
Categories: Homo sapiens | Arrowsmith, C H. | Bochkarev, A. | Bountra, C. | Edwards, A M. | MacKenzie, F. | Park, H. | SGC, Structural Genomics Consortium. | Shen, L. | Tempel, W. | Tong, Y. | Weigelt, J. | Atp-binding | Cytoskeleton | Gap | Gtpase activation | Kinesin | Metal-binding | Microtubule | Motor protein | Nucleotide-binding | Nucleus | Phosphoprotein | Sgc | Structural genomics consortium | Transport protein-hydrolase activator complex | Zinc-finger
