2j8h
From Proteopedia
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| - | [[Image:2j8h.jpg|left|200px]]<br /><applet load="2j8h" size=" | + | [[Image:2j8h.jpg|left|200px]]<br /><applet load="2j8h" size="350" color="white" frame="true" align="right" spinBox="true" |
caption="2j8h, resolution 1.99Å" /> | caption="2j8h, resolution 1.99Å" /> | ||
'''STRUCTURE OF THE IMMUNOGLOBULIN TANDEM REPEAT A168-A169 OF TITIN'''<br /> | '''STRUCTURE OF THE IMMUNOGLOBULIN TANDEM REPEAT A168-A169 OF TITIN'''<br /> | ||
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==Overview== | ==Overview== | ||
Most of the structure of the giant muscle protein titin is formed by small, modular domains. Many of them are predicted to be arranged in repeats with, short linkers that may be key determinants of the peculiar elastic, properties of titin. Here, we present the molecular structure of a tandem, arrangement of two immunoglobulin-like domains, A168 and A169, located, within the A-band segment of titin. The two domains are connected by a 17, residue long beta-strand and form a common interface. Based on these data, we establish general principles to estimate the amount of conformational, flexibility of tandem domain motifs in titin. An unusual bulge within the, second domain, A169, is directly involved into binding to a sarcomeric, ligand, MURF-1, thus suggesting a dual role of this tandem for both the, mechanical properties of titin and for sarcomeric signaling. | Most of the structure of the giant muscle protein titin is formed by small, modular domains. Many of them are predicted to be arranged in repeats with, short linkers that may be key determinants of the peculiar elastic, properties of titin. Here, we present the molecular structure of a tandem, arrangement of two immunoglobulin-like domains, A168 and A169, located, within the A-band segment of titin. The two domains are connected by a 17, residue long beta-strand and form a common interface. Based on these data, we establish general principles to estimate the amount of conformational, flexibility of tandem domain motifs in titin. An unusual bulge within the, second domain, A169, is directly involved into binding to a sarcomeric, ligand, MURF-1, thus suggesting a dual role of this tandem for both the, mechanical properties of titin and for sarcomeric signaling. | ||
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| - | ==Disease== | ||
| - | Known diseases associated with this structure: Cardiomyopathy, dilated, 1G OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=188840 188840]], Cardiomyopathy, familial hypertrophic OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=188840 188840]], Muscular dystrophy, limb-girdle, type 2J OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=188840 188840]], Myopathy, proximal, with early respiratory muscle involvement OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=188840 188840]], Tibial muscular dystrophy, tardive OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=188840 188840]] | ||
==About this Structure== | ==About this Structure== | ||
| - | 2J8H is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with GOL as [http://en.wikipedia.org/wiki/ligand ligand]. Active as [http://en.wikipedia.org/wiki/Non-specific_serine/threonine_protein_kinase Non-specific serine/threonine protein kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.11.1 2.7.11.1] Known structural/functional Site: <scene name='pdbsite=AC1:Gol Binding Site For Chain A'>AC1</scene>. Full crystallographic information is available from [http:// | + | 2J8H is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with <scene name='pdbligand=GOL:'>GOL</scene> as [http://en.wikipedia.org/wiki/ligand ligand]. Active as [http://en.wikipedia.org/wiki/Non-specific_serine/threonine_protein_kinase Non-specific serine/threonine protein kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.11.1 2.7.11.1] Known structural/functional Site: <scene name='pdbsite=AC1:Gol Binding Site For Chain A'>AC1</scene>. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2J8H OCA]. |
==Reference== | ==Reference== | ||
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[[Category: wd repeat]] | [[Category: wd repeat]] | ||
| - | ''Page seeded by [http:// | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jan 23 14:00:25 2008'' |
Revision as of 12:00, 23 January 2008
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STRUCTURE OF THE IMMUNOGLOBULIN TANDEM REPEAT A168-A169 OF TITIN
Overview
Most of the structure of the giant muscle protein titin is formed by small, modular domains. Many of them are predicted to be arranged in repeats with, short linkers that may be key determinants of the peculiar elastic, properties of titin. Here, we present the molecular structure of a tandem, arrangement of two immunoglobulin-like domains, A168 and A169, located, within the A-band segment of titin. The two domains are connected by a 17, residue long beta-strand and form a common interface. Based on these data, we establish general principles to estimate the amount of conformational, flexibility of tandem domain motifs in titin. An unusual bulge within the, second domain, A169, is directly involved into binding to a sarcomeric, ligand, MURF-1, thus suggesting a dual role of this tandem for both the, mechanical properties of titin and for sarcomeric signaling.
About this Structure
2J8H is a Single protein structure of sequence from Homo sapiens with as ligand. Active as Non-specific serine/threonine protein kinase, with EC number 2.7.11.1 Known structural/functional Site: . Full crystallographic information is available from OCA.
Reference
Rigid Conformation of an Immunoglobulin Domain Tandem Repeat in the A-band of the Elastic Muscle Protein Titin., Muller S, Lange S, Gautel M, Wilmanns M, J Mol Biol. 2007 Aug 10;371(2):469-80. Epub 2007 May 25. PMID:17574571
Page seeded by OCA on Wed Jan 23 14:00:25 2008
Categories: Homo sapiens | Non-specific serine/threonine protein kinase | Single protein | Gautel, M. | Kursula, I. | Lange, S. | Mueller, S. | Wilmanns, M. | GOL | A-band | Alternative splicing | Atp-binding | Cardiomyopathy | Coiled coil | Disease mutation | Immunoglobulin domain | Immunoglobulin like domain | Kelch repeat | Kinase | Limb-girdle muscular dystrophy | Nuclear protein | Nucleotide-binding | Phosphorylation | Polymorphism | Serine/threonine-protein kinase | Structural protein | Titin | Tpr repeat | Transferase | Wd repeat
