3l0y
From Proteopedia
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{{STRUCTURE_3l0y| PDB=3l0y | SCENE= }} | {{STRUCTURE_3l0y| PDB=3l0y | SCENE= }} | ||
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===Crystal structure OF SCP1 phosphatase D98A mutant=== | ===Crystal structure OF SCP1 phosphatase D98A mutant=== | ||
| + | {{ABSTRACT_PUBMED_20222012}} | ||
| - | + | ==Function== | |
| - | + | [[http://www.uniprot.org/uniprot/CTDS1_HUMAN CTDS1_HUMAN]] Preferentially catalyzes the dephosphorylation of 'Ser-5' within the tandem 7 residues repeats in the C-terminal domain (CTD) of the largest RNA polymerase II subunit POLR2A. Negatively regulates RNA polymerase II transcription, possibly by controlling the transition from initiation/capping to processive transcript elongation. Recruited by REST to neuronal genes that contain RE-1 elements, leading to neuronal gene silencing in non-neuronal cells.<ref>PMID:12721286</ref> <ref>PMID:15681389</ref> | |
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==About this Structure== | ==About this Structure== | ||
| - | + | [[3l0y]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3L0Y OCA]. | |
==Reference== | ==Reference== | ||
| - | <ref group="xtra">PMID: | + | <ref group="xtra">PMID:020222012</ref><references group="xtra"/><references/> |
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
[[Category: Phosphoprotein phosphatase]] | [[Category: Phosphoprotein phosphatase]] | ||
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[[Category: Protein phosphatase]] | [[Category: Protein phosphatase]] | ||
[[Category: Small c-terminal domain phosphatase]] | [[Category: Small c-terminal domain phosphatase]] | ||
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| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Aug 12 00:08:42 2010'' | ||
Revision as of 20:47, 4 April 2013
Contents |
Crystal structure OF SCP1 phosphatase D98A mutant
Template:ABSTRACT PUBMED 20222012
Function
[CTDS1_HUMAN] Preferentially catalyzes the dephosphorylation of 'Ser-5' within the tandem 7 residues repeats in the C-terminal domain (CTD) of the largest RNA polymerase II subunit POLR2A. Negatively regulates RNA polymerase II transcription, possibly by controlling the transition from initiation/capping to processive transcript elongation. Recruited by REST to neuronal genes that contain RE-1 elements, leading to neuronal gene silencing in non-neuronal cells.[1] [2]
About this Structure
3l0y is a 2 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA.
Reference
- Zhang M, Liu J, Kim Y, Dixon JE, Pfaff SL, Gill GN, Noel JP, Zhang Y. Structural and functional analysis of the phosphoryl transfer reaction mediated by the human small C-terminal domain phosphatase, Scp1. Protein Sci. 2010 Mar 10. PMID:20222012 doi:10.1002/pro.375
- ↑ Yeo M, Lin PS, Dahmus ME, Gill GN. A novel RNA polymerase II C-terminal domain phosphatase that preferentially dephosphorylates serine 5. J Biol Chem. 2003 Jul 11;278(28):26078-85. Epub 2003 Apr 28. PMID:12721286 doi:10.1074/jbc.M301791200
- ↑ Yeo M, Lee SK, Lee B, Ruiz EC, Pfaff SL, Gill GN. Small CTD phosphatases function in silencing neuronal gene expression. Science. 2005 Jan 28;307(5709):596-600. PMID:15681389 doi:10.1126/science.1100801
