3n9m

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[[Image:3n9m.png|left|200px]]
 
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{{STRUCTURE_3n9m| PDB=3n9m | SCENE= }}
{{STRUCTURE_3n9m| PDB=3n9m | SCENE= }}
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===ceKDM7A from C.elegans, alone===
===ceKDM7A from C.elegans, alone===
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{{ABSTRACT_PUBMED_20567261}}
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==Function==
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[[http://www.uniprot.org/uniprot/Q9GYI0_CAEEL Q9GYI0_CAEEL]] Histone demethylase required for nervous system development. Specifically demethylates dimethylated 'Lys-9' and 'Lys-27' (H3K9me2 and H3K27me2, respectively) of histone H3, thereby playing a central role in histone code.<ref>PMID:20567262</ref> <ref>PMID:20346720</ref> <ref>PMID:20567261</ref>
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{{ABSTRACT_PUBMED_20567261}}
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==About this Structure==
==About this Structure==
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3N9M is a 2 chains structure with sequences from [http://en.wikipedia.org/wiki/Caenorhabditis_elegans Caenorhabditis elegans]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3N9M OCA].
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[[3n9m]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Caenorhabditis_elegans Caenorhabditis elegans]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3N9M OCA].
==Reference==
==Reference==
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<ref group="xtra">PMID:20567261</ref><references group="xtra"/>
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<ref group="xtra">PMID:020567261</ref><references group="xtra"/><references/>
[[Category: Caenorhabditis elegans]]
[[Category: Caenorhabditis elegans]]
[[Category: Chen, C D.]]
[[Category: Chen, C D.]]
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[[Category: Oxidoreductase]]
[[Category: Oxidoreductase]]
[[Category: Phd]]
[[Category: Phd]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Aug 12 00:13:19 2010''
 

Revision as of 21:08, 17 April 2013

Template:STRUCTURE 3n9m

Contents

ceKDM7A from C.elegans, alone

Template:ABSTRACT PUBMED 20567261

Function

[Q9GYI0_CAEEL] Histone demethylase required for nervous system development. Specifically demethylates dimethylated 'Lys-9' and 'Lys-27' (H3K9me2 and H3K27me2, respectively) of histone H3, thereby playing a central role in histone code.[1] [2] [3]

About this Structure

3n9m is a 2 chain structure with sequence from Caenorhabditis elegans. Full crystallographic information is available from OCA.

Reference

  • Yang Y, Hu L, Wang P, Hou H, Lin Y, Liu Y, Li Z, Gong R, Feng X, Zhou L, Zhang W, Dong Y, Yang H, Lin H, Wang Y, Chen CD, Xu Y. Structural insights into a dual-specificity histone demethylase ceKDM7A from Caenorhabditis elegans. Cell Res. 2010 Aug;20(8):886-98. Epub 2010 Jun 22. PMID:20567261 doi:10.1038/cr.2010.86
  1. ↑ Lin H, Wang Y, Wang Y, Tian F, Pu P, Yu Y, Mao H, Yang Y, Wang P, Hu L, Lin Y, Liu Y, Xu Y, Chen CD. Coordinated regulation of active and repressive histone methylations by a dual-specificity histone demethylase ceKDM7A from Caenorhabditis elegans. Cell Res. 2010 Aug;20(8):899-907. doi: 10.1038/cr.2010.84. Epub 2010 Jun 22. PMID:20567262 doi:10.1038/cr.2010.84
  2. ↑ Kleine-Kohlbrecher D, Christensen J, Vandamme J, Abarrategui I, Bak M, Tommerup N, Shi X, Gozani O, Rappsilber J, Salcini AE, Helin K. A functional link between the histone demethylase PHF8 and the transcription factor ZNF711 in X-linked mental retardation. Mol Cell. 2010 Apr 23;38(2):165-78. doi: 10.1016/j.molcel.2010.03.002. Epub 2010 , Mar 25. PMID:20346720 doi:10.1016/j.molcel.2010.03.002
  3. ↑ Yang Y, Hu L, Wang P, Hou H, Lin Y, Liu Y, Li Z, Gong R, Feng X, Zhou L, Zhang W, Dong Y, Yang H, Lin H, Wang Y, Chen CD, Xu Y. Structural insights into a dual-specificity histone demethylase ceKDM7A from Caenorhabditis elegans. Cell Res. 2010 Aug;20(8):886-98. Epub 2010 Jun 22. PMID:20567261 doi:10.1038/cr.2010.86

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