3kku
From Proteopedia
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===Cruzain in complex with a non-covalent ligand=== | ===Cruzain in complex with a non-covalent ligand=== | ||
| + | {{ABSTRACT_PUBMED_20540517}} | ||
| - | + | ==Function== | |
| - | + | [[http://www.uniprot.org/uniprot/CYSP_TRYCR CYSP_TRYCR]] Hydrolyzes chromogenic peptides at the carboxyl Arg or Lys; requires at least one more amino acid, preferably Arg, Phe, Val or Leu, between the terminal Arg or Lys and the amino-blocking group. The cysteine protease may play an important role in the development and differentiation of the parasites at several stages of their life cycle. | |
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==About this Structure== | ==About this Structure== | ||
| - | + | [[3kku]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Trypanosoma_cruzi Trypanosoma cruzi]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3KKU OCA]. | |
==Reference== | ==Reference== | ||
| - | <ref group="xtra">PMID: | + | <ref group="xtra">PMID:020540517</ref><references group="xtra"/><references/> |
[[Category: Cruzipain]] | [[Category: Cruzipain]] | ||
[[Category: Trypanosoma cruzi]] | [[Category: Trypanosoma cruzi]] | ||
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[[Category: Thiol protease]] | [[Category: Thiol protease]] | ||
[[Category: Zymogen]] | [[Category: Zymogen]] | ||
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| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Aug 18 11:04:40 2010'' | ||
Revision as of 02:09, 4 April 2013
Contents |
Cruzain in complex with a non-covalent ligand
Template:ABSTRACT PUBMED 20540517
Function
[CYSP_TRYCR] Hydrolyzes chromogenic peptides at the carboxyl Arg or Lys; requires at least one more amino acid, preferably Arg, Phe, Val or Leu, between the terminal Arg or Lys and the amino-blocking group. The cysteine protease may play an important role in the development and differentiation of the parasites at several stages of their life cycle.
About this Structure
3kku is a 1 chain structure with sequence from Trypanosoma cruzi. Full crystallographic information is available from OCA.
Reference
- Ferreira RS, Simeonov A, Jadhav A, Eidam O, Mott BT, Keiser MJ, McKerrow JH, Maloney DJ, Irwin JJ, Shoichet BK. Complementarity between a docking and a high-throughput screen in discovering new cruzain inhibitors. J Med Chem. 2010 Jul 8;53(13):4891-905. PMID:20540517 doi:10.1021/jm100488w
