2jdk
From Proteopedia
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| - | [[Image:2jdk.gif|left|200px]]<br /><applet load="2jdk" size=" | + | [[Image:2jdk.gif|left|200px]]<br /><applet load="2jdk" size="350" color="white" frame="true" align="right" spinBox="true" |
caption="2jdk, resolution 1.10Å" /> | caption="2jdk, resolution 1.10Å" /> | ||
'''LECTIN PA-IIL OF P.AERUGINOSA COMPLEXED WITH DISACCHARIDE DERIVATIVE'''<br /> | '''LECTIN PA-IIL OF P.AERUGINOSA COMPLEXED WITH DISACCHARIDE DERIVATIVE'''<br /> | ||
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==About this Structure== | ==About this Structure== | ||
| - | 2JDK is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Pseudomonas_aeruginosa Pseudomonas aeruginosa] with FUC, CA and SO4 as [http://en.wikipedia.org/wiki/ligands ligands]. Known structural/functional Site: <scene name='pdbsite=AC1:T45 Binding Site For Chain C'>AC1</scene>. Full crystallographic information is available from [http:// | + | 2JDK is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Pseudomonas_aeruginosa Pseudomonas aeruginosa] with <scene name='pdbligand=FUC:'>FUC</scene>, <scene name='pdbligand=CA:'>CA</scene> and <scene name='pdbligand=SO4:'>SO4</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. Known structural/functional Site: <scene name='pdbsite=AC1:T45 Binding Site For Chain C'>AC1</scene>. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JDK OCA]. |
==Reference== | ==Reference== | ||
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[[Category: pseudomonas aeruginosa]] | [[Category: pseudomonas aeruginosa]] | ||
| - | ''Page seeded by [http:// | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jan 23 13:37:10 2008'' |
Revision as of 11:37, 23 January 2008
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LECTIN PA-IIL OF P.AERUGINOSA COMPLEXED WITH DISACCHARIDE DERIVATIVE
Overview
Pseudomonas aeruginosa is an opportunistic bacterium showing increasing, resistance to antibiotics and consequently represents elevated threatening, problems in hospital environments, particularly for cystic fibrosis, patients. The use of glycomimetics as an anti-adhesive strategy against, microorganisms may complement the use of antibiotics. PA-IIL lectin (LecB), from P. aeruginosa constitutes an appealing target for antibacterial, agents, as it has been proposed to play a key role in binding to airway, epithelia and/or to be involved in biofilm formation. The lectin has an, unusually high affinity for L-fucose and related oligosaccharides. In the, work presented herein, the disaccharide alphaFuc1-4GlcNAc is used as a, scaffold toward the synthesis of a series of glycomimetic derivatives., Microcalorimetry and structural studies indicate that several of the, derivatives are potent inhibitors of the lectin, with affinity in the same, range as the best known natural ligand, Lewis a, and could represent, interesting leads for the development of future antibacterial compounds.
About this Structure
2JDK is a Single protein structure of sequence from Pseudomonas aeruginosa with , and as ligands. Known structural/functional Site: . Full crystallographic information is available from OCA.
Reference
X-ray Structures and Thermodynamics of the Interaction of PA-IIL from Pseudomonas aeruginosa with Disaccharide Derivatives., Marotte K, Sabin C, Preville C, Moume-Pymbock M, Wimmerova M, Mitchell EP, Imberty A, Roy R, ChemMedChem. 2007 Jul 10;. PMID:17623286
Page seeded by OCA on Wed Jan 23 13:37:10 2008
Categories: Pseudomonas aeruginosa | Single protein | Deguise, I. | Imberty, A. | Marotte, K. | Mitchell, E.P. | Preville, C. | Pymbock, M. | Roy, R. | Sabin, C. | Wimmerova, M. | CA | FUC | SO4 | Cystic fibrosis | Glycomimetic | Lectin
