2jiz
From Proteopedia
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| - | [[Image:2jiz.jpg|left|200px]]<br /><applet load="2jiz" size=" | + | [[Image:2jiz.jpg|left|200px]]<br /><applet load="2jiz" size="350" color="white" frame="true" align="right" spinBox="true" |
caption="2jiz, resolution 2.30Å" /> | caption="2jiz, resolution 2.30Å" /> | ||
'''THE STRUCTURE OF F1-ATPASE INHIBITED BY RESVERATROL.'''<br /> | '''THE STRUCTURE OF F1-ATPASE INHIBITED BY RESVERATROL.'''<br /> | ||
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==About this Structure== | ==About this Structure== | ||
| - | 2JIZ is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/Bos_taurus Bos taurus] with MG, AZI, PO4, ANP, ADP, STL and GOL as [http://en.wikipedia.org/wiki/ligands ligands]. Active as [http://en.wikipedia.org/wiki/Transferred_entry:_3.6.3.14 Transferred entry: 3.6.3.14], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.6.1.34 3.6.1.34] Known structural/functional Site: <scene name='pdbsite=AC1:Stl Binding Site For Chain N'>AC1</scene>. Full crystallographic information is available from [http:// | + | 2JIZ is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/Bos_taurus Bos taurus] with <scene name='pdbligand=MG:'>MG</scene>, <scene name='pdbligand=AZI:'>AZI</scene>, <scene name='pdbligand=PO4:'>PO4</scene>, <scene name='pdbligand=ANP:'>ANP</scene>, <scene name='pdbligand=ADP:'>ADP</scene>, <scene name='pdbligand=STL:'>STL</scene> and <scene name='pdbligand=GOL:'>GOL</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. Active as [http://en.wikipedia.org/wiki/Transferred_entry:_3.6.3.14 Transferred entry: 3.6.3.14], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.6.1.34 3.6.1.34] Known structural/functional Site: <scene name='pdbsite=AC1:Stl Binding Site For Chain N'>AC1</scene>. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JIZ OCA]. |
==Reference== | ==Reference== | ||
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[[Category: transport]] | [[Category: transport]] | ||
| - | ''Page seeded by [http:// | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jan 23 13:42:38 2008'' |
Revision as of 11:42, 23 January 2008
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THE STRUCTURE OF F1-ATPASE INHIBITED BY RESVERATROL.
Overview
The structures of F(1)-ATPase from bovine heart mitochondria inhibited, with the dietary phytopolyphenol, resveratrol, and with the related, polyphenols quercetin and piceatannol have been determined at 2.3-, 2.4-, and 2.7-A resolution, respectively. The inhibitors bind to a common site, in the inside surface of an annulus made from loops in the three alpha-, and three beta-subunits beneath the "crown" of beta-strands in their, N-terminal domains. This region of F(1)-ATPase forms a bearing to allow, the rotation of the tip of the gamma-subunit inside the annulus during, catalysis. The binding site is a hydrophobic pocket between the C-terminal, tip of the gamma-subunit and the beta(TP) subunit, and the inhibitors are, bound via H-bonds mostly to their hydroxyl moieties mediated by bound, water molecules and by hydrophobic interactions. There are no equivalent, sites between the gamma-subunit and either the beta(DP) or the beta(E), subunit. The inhibitors probably prevent both the synthetic and hydrolytic, activities of the enzyme by blocking both senses of rotation of the, gamma-subunit. The beneficial effects of dietary resveratrol may derive in, part by preventing mitochondrial ATP synthesis in tumor cells, thereby, inducing apoptosis.
About this Structure
2JIZ is a Protein complex structure of sequences from Bos taurus with , , , , , and as ligands. Active as Transferred entry: 3.6.3.14, with EC number 3.6.1.34 Known structural/functional Site: . Full crystallographic information is available from OCA.
Reference
Mechanism of inhibition of bovine F1-ATPase by resveratrol and related polyphenols., Gledhill JR, Montgomery MG, Leslie AG, Walker JE, Proc Natl Acad Sci U S A. 2007 Aug 21;104(34):13632-7. Epub 2007 Aug 13. PMID:17698806
Page seeded by OCA on Wed Jan 23 13:42:38 2008
Categories: Bos taurus | Protein complex | Transferred entry: 3.6.3.14 | Gledhill, J.R. | Leslie, A.G.W. | Montgomery, M.G. | Walker, J.E. | ADP | ANP | AZI | GOL | MG | PO4 | STL | Acetylation | Alternative splicing | Atp synthesis | Atp-binding | Bovine | Cf(1) | F1-atpase | Hydrogen ion transport | Hydrolase | Hydrolysis | Ion transport | Mitochondrial | Mitochondrion | Nucleotide-binding | Pyrrolidone carboxylic acid | Resveratrol | Transit peptide | Transport
