Cyclophilin

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
(New page: Crystal Structure of human Cyclophilin-A, 2x25 {{STRUCTURE_2x25| PDB=2x25 | SIZE=300| SCENE= |right|CAPTION=human Cyclophilin-A, 2x25 }} Cycl...)
Line 1: Line 1:
-
[[Image:2x25.png|left|200px|thumb|Crystal Structure of human Cyclophilin-A, [[2x25]]]]
+
[[Image:2x25.jpg|left|200px|thumb|Crystal Structure of human Cyclophilin-A, [[2x25]]]]
{{STRUCTURE_2x25| PDB=2x25 | SIZE=300| SCENE= |right|CAPTION=human Cyclophilin-A, [[2x25]] }}
{{STRUCTURE_2x25| PDB=2x25 | SIZE=300| SCENE= |right|CAPTION=human Cyclophilin-A, [[2x25]] }}
-
Cyclophilin (Cyp) binds cyclosporin. They are peptidylprolyl isomerases which catalyze the isomerisation of proline. The Cyp-A/cyclosporin A complex inhibits organ rejection. Cyp-D is a component of the mitochondria permeability pore. Rotamase such as FKBP is a prokaryotic Cyp which is not inhibited by cyclosporin but by FK-506 – an immunosuppressive drug.
+
[[Cyclophilin]] (Cyp) binds cyclosporin. They are peptidylprolyl isomerases which catalyze the isomerisation of proline. The Cyp-A/cyclosporin A complex inhibits organ rejection. Cyp-D is a component of the mitochondria permeability pore. Rotamase such as FKBP is a prokaryotic Cyp which is not inhibited by cyclosporin but by FK-506 – an immunosuppressive drug. The images at the left and at the right correspond to one representative Cyclophilin, ''i.e.'' crystal structure of human Cyclophilin A ([[2x25]]).
 +
 
 +
{{TOC limit|limit=2}}
 +
 
 +
== 3D Structures of Cyclophilin ==
 +
 
 +
 
 +
=== Cyclophilin-A ===
 +
 
 +
 
 +
[[2x25]], [[2x2a]], [[3k0m]], [[3k0n]], [[1w8l]], [[1w8m]], [[1w8v]], [[1rmh]], [[2cpl]] – hCyp-A – human
 +
[[1oca]] – hCyp-A - NMR<br />
 +
[[3k0o]], [[3k0p]], [[3k0q]], [[3k0r]], [[2alf]] – hCyp-A (mutant)<br />
 +
[[2a2c]], [[1cwa]], [[1cwb]], [[1cwc]] – hCyp-A+cyclosporin A<br />
 +
[[3cys]] - hCyp-A+cyclosporin A - NMR<br />
 +
[[1cwj]], [[1bck]], [[1cwi]], [[1cwo]], [[1cwf]], [[1cwh]], [[1cwk]], [[1cwl]], [[1cwm]], [[1mik]] - hCyp-A+cyclosporin A derivative<br />
 +
[[2rma]], [[2rmb]] - hCyp-A+cyclosporin A+cyclosporin A derivative<br />
 +
[[1mf8]], [[1m63]] - hCyp-A+cyclosporin A+ calcineurin subunits A,B<br />
 +
[[2x2d]], [[1m9c]], [[1m9d]], [[1m9e]], [[1m9f]], [[1m9x]], [[1m9y]], [[1awq]], [[1awr]], [[1aws]], [[1awt]], [[1awu]], [[1awv]], [[1ak4]], [[1fgl]] - hCyp-A+HIV-1 N-terminal capsid domain<br />
 +
[[1zkf]] – hCyp-A+suc-AGPF-pNA<br />
 +
[[1ynd]], [[1nmk]] – hCyp-A+ sanglifehrin<br />
 +
[[2cyh]], [[3cyh]], [[4cyh]], [[5cyh]] - hCyp-A+dipeptide<br />
 +
[[1vbs]], [[1vbt]] – hCyp-A+tetrapeptide<br />
 +
[[1vdn]] – yCyp-A+peptidyl coumarin – yeast<br />
 +
[[1ist]] – yCyp-A<br />
 +
[[1w74]] – Cyp-A – ''Mycobacterium tuberculosis''<br />
 +
[[1lop]] - EcCyp-A+peptidyl nitroanilide - ''Escherichia coli''<br />
 +
[[1csa]] – EcCyp-A+ cyclosporin A – NMR<br />
 +
 
 +
 
 +
=== Cyclophilin-B ===
 +
 
 +
 
 +
[[3ich]] – hCyp-B<br />
 +
[[3ici]] - hCyp-B+calmegin fragment<br />
 +
[[1v9t]] – EcCyp-B+peptidyl nitroanilide <br />
 +
[[1vai]] - EcCyp-B+peptidyl coumarin<br />
 +
[[1cyn]] – hCyp-B +cyclosporin A derivative<br />
 +
[[1j2a]] – EcCyp-B (mutant)<br />
 +
 
 +
 
 +
=== Cyclophilin-C ===
 +
 
 +
 
 +
[[2esl]] - hCyp-C+cyclosporin A<br />
 +
[[2rmc]] - Cyp-C+cyclosporin A – mouse<br />
 +
 
 +
 
 +
=== Cyclophilin-D ===
 +
 
 +
 
 +
[[2bit]] – hCyp-D<br />
 +
[[2viu]] – hCyp-D+DMSO<br />
 +
[[2z6w]] - hCyp-D+cyclosporin A<br />
 +
 
 +
 
 +
=== Cyclophilin-E ===
 +
 
 +
 
 +
[[2kyx]], [[1zmf]] – hCyp-E PPIASE domain<br />
 +
[[2r99]] - hCyp-E ABH-like domain<br />
 +
[[2cqb]] – hCyp-E RNA recognition motif<br />
 +
[[2ck1]], [[2cmt]] – Cyp-E – ''Schistosoma mansoni''<br />
 +
[[2kyx]] – hCyp-E RRM domain – NMR<br />
 +
[[3lpy]], [[3mdf]] - hCyp-E RRM domain<br />
 +
 
 +
 
 +
=== Cyclophilin-G ===
 +
 
 +
 
 +
[[2wfi]], [[2gw2]] - hCyp-G PPIASE domain<br />
 +
[[2wfj]] - hCyp-G PPIASE domain+cyclosporin A<br />
 +
 
 +
 
 +
=== Cyclophilin-H ===
 +
 
 +
 
 +
[[1mzw]] – hCyp-H+peptide<br />
 +
 
 +
 
 +
=== Cyclophilin-J ===
 +
 
 +
 
 +
[[2ok3]], [[1xyh]] - hCyp-J<br />
 +
[[2oju]] - hCyp-J+cyclosporin A<br />
 +
 
 +
 
 +
=== Cyclophilin-3 ===
 +
 
 +
 
 +
[[2igv]], [[2igw]], [[1e8k]] – CeCyp-3+dipeptide – ''Caenorhabditis elegans''<br />
 +
[[1dyw]] - CeCyp-3<br />
 +
[[1e3b]] – CeCyp-3+AUP(ET)3<br />
 +
 
 +
 
 +
=== Cyclophilin-5 ===
 +
 
 +
 
 +
[[1h0p]] – CeCyp-5 (mutant) <br />
 +
 
 +
Cyclophilin-40
 +
 
 +
[[1ihg]], [[1iip]] – Cyp-40 – bovine<br />
 +
 
 +
 
 +
=== Cyclophilin ===
 +
 
 +
 
 +
[[3bo7]] - TgCyp+cyclosporin A - ''Toxoplasma gondii''<br />
 +
[[2nul]] – EcCyp<br />
 +
[[1clh]] – EcCyp – NMR<br />
 +
[[1qoi]] – hCyp SNUCYP-20<br />
 +
[[3k2c]] – Cyp – ''Encephalitozoon cuniculi''<br />
 +
[[3eov]] - LdCyp+cyclosporin A – ''Leishmania donovani''<br />
 +
[[3bt8]] – LdCyp<br />
 +
[[2haq]] – LdCyp-A<br />
 +
[[2hqj]] – Cyp – ''Leishmania major''<br />
 +
[[3bkp]] – TgCyp<br />
 +
[[2cfe]] – Cyp – ''Malassezia sympodialis''<br />
 +
[[2c3b]] – Cyp – ''Aspergillus fumigatus''<br />
 +
[[1z81]] – Cyp – ''Plasmodium Yoelli''<br />
 +
[[1qng]] – PfCyp+cyclosporin A – ''Plasmodium falciparum''<br />
 +
[[1qnh]] – PfCyp (mutant)+cyclosporin A<br />
 +
[[1xo7]] – TcCyp – ''Trypanosoma cruzi''<br />
 +
[[1xq7]] - TcCyp+cyclosporin A<br />
 +
[[1a58]] - Cyp – ''Brugia malayi''<br />
 +
[[2ko7]] – BpCyp+inhibitor – ''Burkholderia pseudomallei''<br />
 +
[[2ke0]] – BpCyp – NMR
 +
 
 +
 
 +
=== Rotamase (FKBP) ===
 +
 
 +
 
 +
[[1fks]], [[1fkt]], [[1fkr]], [[2kfw]] – EcFKBP – NMR<br />
 +
[[1q6h]], [[1q6u]] – EcFKBP<br />
 +
[[1q6i]] – EcFKBP+FK-506<br />
 +
[[3jxv]], [[3jym]] – FKBP73 – wheat<br />
 +
[[3mdy]] – hFKBP-1A+BMPR1B<br />
 +
[[3h9r]] - hFKBP-1A+ activin receptor type I<br />
 +
[[1j4r]] – hFKBP-1+FKB-001<br />
 +
[[2ppp]], [[2ppn]], [[2dg3]], [[1d6o]] – hFKBP-12<br />
 +
[[2ppo]] – hFKBP-12 (mutant)<br />
 +
[[2dg4]], [[1fkb]] - hFKBP-12+rapamycin<br />
 +
[[2fap]], [[1nsg]], [[1fap]] - hFKBP-12+rapamycin+FRB<br />
 +
[[1f40]] - hFKBP-12+GPI-1046<br />
 +
[[1a7x]] – hFKBP-12+FK-1012<br />
 +
[[1d7h]], [[1d7i]], [[1d7j]], [[1fkg]], [[1fkh]], [[1fki]] - hFKBP-12+ligand<br />
 +
[[2dg9]] - hFKBP-12 (mutant)+rapamycin<br />
 +
[[1fkl]] - cFKBP-12+rapamycin - cow<br />
 +
[[2pbc]] - hFKBP-13<br />
 +
[[1y0o]], [[1u79]] – AtFKBP-13 - ''Arabidopsis thaliana''<br />
 +
[[2kfv]] – hFKBP-25 N-terminal<br />
 +
[[2vn1]] – PfFKBP-35 FK506-binding domain+FK506<br />
 +
[[3b7x]] – hFKBP-36 <br />
 +
[[2if4]] – AtFKBP<br />
 +
[[2f4e]] - AtFKBP-42 N-terminal<br />
 +
[[1kt0]], [[1kt1]] – hFKBP-51 (mutant)<br />
 +
[[1ix5]] – FKBP – ''Methanothermococcus thermolithotrophicus'' – NMR<br />
 +
[[1bl4]] – hFKBP (mutant)+inhibitor<br />
 +
[[1bkf]] – hFKBP (mutant)+FK-506<br />
 +
[[1fkf]] - hFKBP+FK-506<br />
 +
[[1fkr]], [[1fks]], [[1fkt]] – hFKBP - NMR<br />

Revision as of 10:00, 2 September 2010

Image:2x25.jpg
Crystal Structure of human Cyclophilin-A, 2x25

Template:STRUCTURE 2x25

Cyclophilin (Cyp) binds cyclosporin. They are peptidylprolyl isomerases which catalyze the isomerisation of proline. The Cyp-A/cyclosporin A complex inhibits organ rejection. Cyp-D is a component of the mitochondria permeability pore. Rotamase such as FKBP is a prokaryotic Cyp which is not inhibited by cyclosporin but by FK-506 – an immunosuppressive drug. The images at the left and at the right correspond to one representative Cyclophilin, i.e. crystal structure of human Cyclophilin A (2x25).

Contents

3D Structures of Cyclophilin

Cyclophilin-A

2x25, 2x2a, 3k0m, 3k0n, 1w8l, 1w8m, 1w8v, 1rmh, 2cpl – hCyp-A – human 1oca – hCyp-A - NMR
3k0o, 3k0p, 3k0q, 3k0r, 2alf – hCyp-A (mutant)
2a2c, 1cwa, 1cwb, 1cwc – hCyp-A+cyclosporin A
3cys - hCyp-A+cyclosporin A - NMR
1cwj, 1bck, 1cwi, 1cwo, 1cwf, 1cwh, 1cwk, 1cwl, 1cwm, 1mik - hCyp-A+cyclosporin A derivative
2rma, 2rmb - hCyp-A+cyclosporin A+cyclosporin A derivative
1mf8, 1m63 - hCyp-A+cyclosporin A+ calcineurin subunits A,B
2x2d, 1m9c, 1m9d, 1m9e, 1m9f, 1m9x, 1m9y, 1awq, 1awr, 1aws, 1awt, 1awu, 1awv, 1ak4, 1fgl - hCyp-A+HIV-1 N-terminal capsid domain
1zkf – hCyp-A+suc-AGPF-pNA
1ynd, 1nmk – hCyp-A+ sanglifehrin
2cyh, 3cyh, 4cyh, 5cyh - hCyp-A+dipeptide
1vbs, 1vbt – hCyp-A+tetrapeptide
1vdn – yCyp-A+peptidyl coumarin – yeast
1ist – yCyp-A
1w74 – Cyp-A – Mycobacterium tuberculosis
1lop - EcCyp-A+peptidyl nitroanilide - Escherichia coli
1csa – EcCyp-A+ cyclosporin A – NMR


Cyclophilin-B

3ich – hCyp-B
3ici - hCyp-B+calmegin fragment
1v9t – EcCyp-B+peptidyl nitroanilide
1vai - EcCyp-B+peptidyl coumarin
1cyn – hCyp-B +cyclosporin A derivative
1j2a – EcCyp-B (mutant)


Cyclophilin-C

2esl - hCyp-C+cyclosporin A
2rmc - Cyp-C+cyclosporin A – mouse


Cyclophilin-D

2bit – hCyp-D
2viu – hCyp-D+DMSO
2z6w - hCyp-D+cyclosporin A


Cyclophilin-E

2kyx, 1zmf – hCyp-E PPIASE domain
2r99 - hCyp-E ABH-like domain
2cqb – hCyp-E RNA recognition motif
2ck1, 2cmt – Cyp-E – Schistosoma mansoni
2kyx – hCyp-E RRM domain – NMR
3lpy, 3mdf - hCyp-E RRM domain


Cyclophilin-G

2wfi, 2gw2 - hCyp-G PPIASE domain
2wfj - hCyp-G PPIASE domain+cyclosporin A


Cyclophilin-H

1mzw – hCyp-H+peptide


Cyclophilin-J

2ok3, 1xyh - hCyp-J
2oju - hCyp-J+cyclosporin A


Cyclophilin-3

2igv, 2igw, 1e8k – CeCyp-3+dipeptide – Caenorhabditis elegans
1dyw - CeCyp-3
1e3b – CeCyp-3+AUP(ET)3


Cyclophilin-5

1h0p – CeCyp-5 (mutant)

Cyclophilin-40

1ihg, 1iip – Cyp-40 – bovine


Cyclophilin

3bo7 - TgCyp+cyclosporin A - Toxoplasma gondii
2nul – EcCyp
1clh – EcCyp – NMR
1qoi – hCyp SNUCYP-20
3k2c – Cyp – Encephalitozoon cuniculi
3eov - LdCyp+cyclosporin A – Leishmania donovani
3bt8 – LdCyp
2haq – LdCyp-A
2hqj – Cyp – Leishmania major
3bkp – TgCyp
2cfe – Cyp – Malassezia sympodialis
2c3b – Cyp – Aspergillus fumigatus
1z81 – Cyp – Plasmodium Yoelli
1qng – PfCyp+cyclosporin A – Plasmodium falciparum
1qnh – PfCyp (mutant)+cyclosporin A
1xo7 – TcCyp – Trypanosoma cruzi
1xq7 - TcCyp+cyclosporin A
1a58 - Cyp – Brugia malayi
2ko7 – BpCyp+inhibitor – Burkholderia pseudomallei
2ke0 – BpCyp – NMR


Rotamase (FKBP)

1fks, 1fkt, 1fkr, 2kfw – EcFKBP – NMR
1q6h, 1q6u – EcFKBP
1q6i – EcFKBP+FK-506
3jxv, 3jym – FKBP73 – wheat
3mdy – hFKBP-1A+BMPR1B
3h9r - hFKBP-1A+ activin receptor type I
1j4r – hFKBP-1+FKB-001
2ppp, 2ppn, 2dg3, 1d6o – hFKBP-12
2ppo – hFKBP-12 (mutant)
2dg4, 1fkb - hFKBP-12+rapamycin
2fap, 1nsg, 1fap - hFKBP-12+rapamycin+FRB
1f40 - hFKBP-12+GPI-1046
1a7x – hFKBP-12+FK-1012
1d7h, 1d7i, 1d7j, 1fkg, 1fkh, 1fki - hFKBP-12+ligand
2dg9 - hFKBP-12 (mutant)+rapamycin
1fkl - cFKBP-12+rapamycin - cow
2pbc - hFKBP-13
1y0o, 1u79 – AtFKBP-13 - Arabidopsis thaliana
2kfv – hFKBP-25 N-terminal
2vn1 – PfFKBP-35 FK506-binding domain+FK506
3b7x – hFKBP-36
2if4 – AtFKBP
2f4e - AtFKBP-42 N-terminal
1kt0, 1kt1 – hFKBP-51 (mutant)
1ix5 – FKBP – Methanothermococcus thermolithotrophicus – NMR
1bl4 – hFKBP (mutant)+inhibitor
1bkf – hFKBP (mutant)+FK-506
1fkf - hFKBP+FK-506
1fkr, 1fks, 1fkt – hFKBP - NMR

Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Alexander Berchansky

Retrieved from "http://52.214.119.220/wiki/index.php/Cyclophilin"
Personal tools