1gzp

From Proteopedia

Revision as of 13:19, 30 October 2007

CD1B IN COMPLEX WITH GM2 GANGLIOSIDE

Overview

The human genome encodes five nonpolymorphic major histocompatibility, complex class I-like glycoproteins, CD1a to CD1e, that present lipid, antigens for specific recognition by T lymphocytes. Using single alkyl, chain detergents, we developed a protocol to generate recombinant human, CD1b-lipid complexes. We present here the crystal structures of CD1b in, complex with either phosphatidylinositol or ganglioside GM2 at 2.3 A and, 2.8 A resolutions, respectively. The antigen-binding groove houses four, interlinked hydrophobic channels that are occupied by the alkyl chains of, the glycolipid plus two detergent molecules. A distinct exit beneath the, alpha 2 helix further contributes to the plasticity of the binding groove., These structures reveal the mechanism by which two alkyl chain ... [(full description)]

About this Structure

1GZP is a [Protein complex] structure of sequences from [Homo sapiens] with GM2, D12 and TWT as [ligands]. Structure known Active Site: AC1. Full crystallographic information is available from [OCA].

Reference

Structure of human CD1b with bound ligands at 2.3 A, a maze for alkyl chains., Gadola SD, Zaccai NR, Harlos K, Shepherd D, Castro-Palomino JC, Ritter G, Schmidt RR, Jones EY, Cerundolo V, Nat Immunol. 2002 Aug;3(8):721-6. Epub 2002 Jul 15. PMID:12118248

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