2jwa
From Proteopedia
(New page: 200px<br /><applet load="2jwa" size="350" color="white" frame="true" align="right" spinBox="true" caption="2jwa" /> '''ErbB2 transmembrane segment dimer spatial st...) |
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==Overview== | ==Overview== | ||
| - | Proper lateral dimerization of transmembrane domain of receptor tyrosine | + | Proper lateral dimerization of transmembrane domain of receptor tyrosine kinases is required for biochemical signal transduction across plasma membrane. Spatial structure of dimeric transmembrane domain of the growth factor receptor ErbB2 embedded into lipid bicelle was obtained by solution NMR followed by molecular dynamics relaxation in explicit lipid bilayer. ErbB2 transmembrane segments associate in a right-handed alpha-helical bundle through the N-terminal tandem GG4-like motif T(652)X(3)S(656)X(3)G(660), providing explanation for pathogenic power of some oncogenic mutations. |
==About this Structure== | ==About this Structure== | ||
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[[Category: Receptor protein-tyrosine kinase]] | [[Category: Receptor protein-tyrosine kinase]] | ||
[[Category: Single protein]] | [[Category: Single protein]] | ||
| - | [[Category: Arseniev, A | + | [[Category: Arseniev, A S.]] |
| - | [[Category: Bocharov, E | + | [[Category: Bocharov, E V.]] |
| - | [[Category: Mineev, K | + | [[Category: Mineev, K S.]] |
[[Category: atp-binding]] | [[Category: atp-binding]] | ||
[[Category: erbb2]] | [[Category: erbb2]] | ||
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[[Category: tyrosine-protein kinase]] | [[Category: tyrosine-protein kinase]] | ||
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 18:06:18 2008'' |
Revision as of 16:06, 21 February 2008
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ErbB2 transmembrane segment dimer spatial structure
Overview
Proper lateral dimerization of transmembrane domain of receptor tyrosine kinases is required for biochemical signal transduction across plasma membrane. Spatial structure of dimeric transmembrane domain of the growth factor receptor ErbB2 embedded into lipid bicelle was obtained by solution NMR followed by molecular dynamics relaxation in explicit lipid bilayer. ErbB2 transmembrane segments associate in a right-handed alpha-helical bundle through the N-terminal tandem GG4-like motif T(652)X(3)S(656)X(3)G(660), providing explanation for pathogenic power of some oncogenic mutations.
About this Structure
2JWA is a Single protein structure of sequence from Homo sapiens. Active as Receptor protein-tyrosine kinase, with EC number 2.7.10.1 Full crystallographic information is available from OCA.
Reference
Spatial structure of dimeric transmembrane domain of the growth factor receptor ErbB2 presumably corresponding to the receptor active state., Bocharov EV, Mineev KS, Volynsky PE, Ermolyuk YS, Tkach EN, Sobol AG, Chupin VV, Kirpichnikov MP, Efremov RG, Arseniev AS, J Biol Chem. 2008 Jan 4;. PMID:18178548
Page seeded by OCA on Thu Feb 21 18:06:18 2008
Categories: Homo sapiens | Receptor protein-tyrosine kinase | Single protein | Arseniev, A S. | Bocharov, E V. | Mineev, K S. | Atp-binding | Erbb2 | Glycoprotein | Nucleotide-binding | Phosphorylation | Polymorphism | Protein kinase receptor membrane domain | Transferase | Transmembrane helix dimer | Tyrosine-protein kinase
