User:Jennifer VanAusdall/Sandbox 1
From Proteopedia
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==APC Superfamily== | ==APC Superfamily== | ||
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| + | The amino acid/polyamine/organocation (APC) superfamily is among the largest transport superfamilies identified. | ||
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| + | All members of this superfamily exhibit a uniform topology formed by a single polypeptide chain that crosses the membrane 12 times, unless otherwise noted (source). | ||
==10 established protein families== | ==10 established protein families== | ||
'''AAT: Amino Acid Transporter''' | '''AAT: Amino Acid Transporter''' | ||
| + | Unique to bacteria, this is the largest family within the APC superfamily. | ||
'''APA: Basic Amino Acid/Polyamine Transporter''' | '''APA: Basic Amino Acid/Polyamine Transporter''' | ||
| + | The APA family is also unique to bacteria. | ||
'''CAT: Cationic Amino Acid Transporter''' | '''CAT: Cationic Amino Acid Transporter''' | ||
| + | Members of the CAT family are ubiquitous, containing 14 TMs in eukaryotes and 12 TMs in prokaryotes. | ||
'''ACT: Amino Acid/Choline Transporter''' | '''ACT: Amino Acid/Choline Transporter''' | ||
| + | Members of the CAT family can be found in yeast, plants, and fungi. | ||
'''EAT: Ethanolamine Transporter''' | '''EAT: Ethanolamine Transporter''' | ||
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'''SPG: Spore Germination Protein''' | '''SPG: Spore Germination Protein''' | ||
| + | Members of this family are found in prokaryotes and exhibit only 10 transmembrane segments. The 2 segments closest to the C-terminus in other members of this super family appear to have been cleaved when this family was evolving. None of the proteins in this family have been identified as transporters, leading to the possibility that transmembrane segments 11 and 12 are vital for transport function. | ||
'''YAT: Yeast Amino Acid Transporter''' | '''YAT: Yeast Amino Acid Transporter''' | ||
Revision as of 20:46, 2 October 2010
Contents |
APC Superfamily
The amino acid/polyamine/organocation (APC) superfamily is among the largest transport superfamilies identified.
All members of this superfamily exhibit a uniform topology formed by a single polypeptide chain that crosses the membrane 12 times, unless otherwise noted (source).
10 established protein families
AAT: Amino Acid Transporter Unique to bacteria, this is the largest family within the APC superfamily.
APA: Basic Amino Acid/Polyamine Transporter The APA family is also unique to bacteria.
CAT: Cationic Amino Acid Transporter Members of the CAT family are ubiquitous, containing 14 TMs in eukaryotes and 12 TMs in prokaryotes.
ACT: Amino Acid/Choline Transporter Members of the CAT family can be found in yeast, plants, and fungi.
EAT: Ethanolamine Transporter
ABT: Archaeal/Bacterial Transporter
GGA: Glutamate:GABA Antiporter
LAT: L-type Amino Acid Transporter
SPG: Spore Germination Protein Members of this family are found in prokaryotes and exhibit only 10 transmembrane segments. The 2 segments closest to the C-terminus in other members of this super family appear to have been cleaved when this family was evolving. None of the proteins in this family have been identified as transporters, leading to the possibility that transmembrane segments 11 and 12 are vital for transport function.
YAT: Yeast Amino Acid Transporter
