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Cathepsin

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(New page: Crystal structure wild-type human procathepsin B, 1pbh {{STRUCTURE_1pbh| PDB=1pbh | SIZE=300| SCENE= |right|CAPTION=human procathepsin B, 1pbh...)
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{{STRUCTURE_1pbh| PDB=1pbh | SIZE=300| SCENE= |right|CAPTION=human procathepsin B, [[1pbh]] }}
{{STRUCTURE_1pbh| PDB=1pbh | SIZE=300| SCENE= |right|CAPTION=human procathepsin B, [[1pbh]] }}
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[[Cathepsin]] (CTS) is a protease which becomes activated at low pH. It is found in lysosomes. Members of the CTS group are denoted as CTSA, CTSB etc and cleave proteins at different peptide bonds. The CTSs are expressed as an inactive precursor pro-CTS (PCTS) which become active when a long residue prosegment is cleaved off producing the mature CTS (MCTS).
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[[Cathepsin]] (CTS) is a protease which becomes activated at low pH. It is found in lysosomes. Members of the CTS group are denoted as CTSA, CTSB etc and cleave proteins at different peptide bonds. The CTSs are expressed as an inactive precursor pro-CTS (PCTS) which become active when a long residue prosegment is cleaved off producing the mature CTS (MCTS). The images at the left and at the right correspond to one representative Cathepsin, ''i.e.'' the crystal structure of wild-type human procathepsin B ([[1pbh]]).
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== 3D Structures of Cathepsin ==
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=== Procathepsin-B ===
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[[1pbh]], [[2pbh]], [[3pbh]] – hPCTSB - human
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=== Cathepsin-B mature ===
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[[3hhi]] – TbCTSB (mutant) residues 23-340+CA074 – Trypanosoma brucei
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[[3k9m]] – hMCTSB+stefin A
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[[2ipp]], [[1huc]] – hMCTSB
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[[3cbj]], [[3cbk]] – hMCTSB (mutant)+chagasin
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[[2dc6]], [[2dc7]], [[2dc8]], [[2dc9]], [[2dca]], [[2dcb]], [[2dcc]], [[2dcd]] – bMCTSB+inhibitor – bovine
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[[1sp4]], [[1csb]] – bMCTSB+epoxysuccinyl inhibitor
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[[1ito]], [[1qdq]] – bMCTSB +inhibitor
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[[1gmy]] - bMCTSB +dipeptidyl nitrile
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[[1the]] – rMCTSB (mutant)+butanone inhibitor – rat
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[[1cpj]] - rMCTSB (mutant)
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[[1cte]] - rMCTSB+pyrimidine inhibitor
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=== Cathepsin-C mature ===
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[[2djf]], [[2djg]] – hMCTSC +Gly-Phe-CHN2
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[[1jqp]] – rMCTSC
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[[1k3b]] – hMCTSC
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=== Cathepsin-D mature ===
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[[1lyw]], [[1lya]] – hMCTSD
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[[1lyb]] - hMCTSD+pepstatin
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=== Cathepsin-E mature ===
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[[1tzs]] – hMCTSE+activation peptide from CTSE
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=== Cathepsin-F mature ===
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[[1m6d]] – hMCTSF+piperidine inhibitor
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=== Cathepsin-G mature ===
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[[1kyn]] – hMCTSG +naphthalene inhibitor
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[[1au8]], [[1cgh]] - hMCTSG +phosphonate inhibitor
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=== Cathepsin-H mature ===
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[[1nb]]3, [[1nb5]] – pMCTSH +stefin A – pig
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[[8pch]] - pMCTSH
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=== Cathepsin-K mature ===
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[[3o1g]], [[3n3g]], [[2r6n]], [[1bgo]], [[3kwz]], [[3kx1]] – hMCTSK+ pyrimidine inhibitor
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[[3mpe]], [[3mpf]] – hMCTSK (mutant) + pyrimidine inhibitor
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[[3h7d]] - hMCTSK (mutant) + chondroitin-4-sulfate
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[[3c9e]] - hMCTSK + chondroitin-4-sulfate
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[[3kwb]] - hMCTSK (mutant)+dioxo-triazine
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[[3kw9]] - hMCTSK +triazine
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[[1yk8]] - hMCTSK + cyanamide inhibitor
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[[1yt7]] - hMCTSK + ketoamide inhibitor
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[[2aux]], [[2auz]] - hMCTSK + semicarbazone inhibitor
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[[1ayu]], [[1ayv]], [[1ayw]] - hMCTSK + carbohydrazide inhibitor
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[[2bdl]], [[1yk7]], [[1tu6]], [[1au3]], [[1au4]] - hMCTSK + pyrrolidine inhibitor
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[[1snk]] - hMCTSK + norleucine inhibitor
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[[1nl6]], [[1nlj]] - hMCTSK+ azepanone inhibitor
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[[1q6k]] - hMCTSK+carbamate inhibitor
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[[1au0]] - hMCTSK+ diacylaminoethyl ketone inhibitor
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[[1au2]] - hMCTSK+ propanone inhibitor
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[[1atk]] – hMCTSK+guanidine inhibitor
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[[1vsn]] - hMCTSK+ inhibitor
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[[2ato]] – hMCTSK+myocrisin
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[[1u9v]], [[1u9x]], [[1mem]] – hMCTSK+piperazine inhibitor
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[[1u9w]] - hMCTSK+imidazole inhibitor
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[[2ftd]] – MCTSK+azepan inhibitor – Macaca mulatta
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[[2f7d]] – MCTSK (mutant)+nitrile inhibitor - rabbit
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=== Cathepsin-L mature ===
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[[3f75]] – MCTSL +CTSL propeptide – Toxoplasma gondii
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[[2p86]] – TbMCTSL +K11002
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[[2nqd]] - CTSL residues 1-220 (mutant)+chagasin – Trypanosoma cruzi
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[[1mhw]] – hMCTSL +tripeptide
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[[1icf]] – hMCTSL +MHC class II fragment
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=== Procathepsin-L1 ===
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[[2o6x]] – hPCTSL1 (mutant) – Fasciola hepatica
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=== Cathepsin-L1 mature ===
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[[3iv2]] – hMCTSL1 (mutant)
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[[3k24]] - hMCTSL1 (mutant) +tripeptide
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[[3bc3]] - hMCTSL1 +inhibitor
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[[3h89]], [[3h8b]], [[3h8c]] - hMCTSL1 (mutant) + retro-binding inhibitor
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[[3hwn]], [[3hha]] – hMCTSL1+pyrazole inhibitor
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=== Cathepsin-L2 mature ===
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[[3h6s]] – hMCTSL2+clitocypin
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[[1fh0]] – hMCTSL2 (mutant) +vinyl sulfone inhibitor
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=== Procathepsin-S ===
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[[2c0y]] – hPCTSS (mutant)
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=== Cathepsin-S mature ===
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[[3n3g]] - hMCTSS+ pyrimidine inhibitor
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[[3kwn]] – hMCTSS (mutant)+ thioether acetamide
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[[3iej]] - hMCTSS (mutant)+pyrazole inhibitor
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[[2h7j]], [[2hxz]]- hMCTSS+triazole inhibitor
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[[2r9m]], [[2r9n]], [[2r9o]] – hMCTSS+piperidine inhibitor
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[[2op3]], [[2hhn]], [[2g7y]], [[2hh5]], [[2f1g]] – hMCTSS+aryl inhibitor
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[[2fud]], [[2fra]], [[2frq]], [[2ft2]], [[1npz]], [[1nqc]] – hMCTSS+inhibitor
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[[2fye]], [[2g6d]] – hMCTSS (mutant)+inhibitor
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[[2fq9]], [[1ms6]] – hMCTSS +nitrile inhibitor
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[[1glo]] - hMCTSS (mutant)
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=== Procathepsin-X ===
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[[1deu]] - hPCTSX
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=== Cathepsin-X mature ===
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[[1ef7]] – hMCTSX

Revision as of 07:08, 13 October 2010

Image:1pbh.png
Crystal structure wild-type human procathepsin B, 1pbh

Template:STRUCTURE 1pbh

Cathepsin (CTS) is a protease which becomes activated at low pH. It is found in lysosomes. Members of the CTS group are denoted as CTSA, CTSB etc and cleave proteins at different peptide bonds. The CTSs are expressed as an inactive precursor pro-CTS (PCTS) which become active when a long residue prosegment is cleaved off producing the mature CTS (MCTS). The images at the left and at the right correspond to one representative Cathepsin, i.e. the crystal structure of wild-type human procathepsin B (1pbh).

Contents

3D Structures of Cathepsin

Procathepsin-B

1pbh, 2pbh, 3pbh – hPCTSB - human


Cathepsin-B mature

3hhi – TbCTSB (mutant) residues 23-340+CA074 – Trypanosoma brucei 3k9m – hMCTSB+stefin A 2ipp, 1huc – hMCTSB 3cbj, 3cbk – hMCTSB (mutant)+chagasin 2dc6, 2dc7, 2dc8, 2dc9, 2dca, 2dcb, 2dcc, 2dcd – bMCTSB+inhibitor – bovine 1sp4, 1csb – bMCTSB+epoxysuccinyl inhibitor 1ito, 1qdq – bMCTSB +inhibitor 1gmy - bMCTSB +dipeptidyl nitrile 1the – rMCTSB (mutant)+butanone inhibitor – rat 1cpj - rMCTSB (mutant) 1cte - rMCTSB+pyrimidine inhibitor


Cathepsin-C mature

2djf, 2djg – hMCTSC +Gly-Phe-CHN2 1jqp – rMCTSC 1k3b – hMCTSC


Cathepsin-D mature

1lyw, 1lya – hMCTSD 1lyb - hMCTSD+pepstatin


Cathepsin-E mature

1tzs – hMCTSE+activation peptide from CTSE


Cathepsin-F mature

1m6d – hMCTSF+piperidine inhibitor


Cathepsin-G mature

1kyn – hMCTSG +naphthalene inhibitor 1au8, 1cgh - hMCTSG +phosphonate inhibitor


Cathepsin-H mature

1nb3, 1nb5 – pMCTSH +stefin A – pig 8pch - pMCTSH


Cathepsin-K mature

3o1g, 3n3g, 2r6n, 1bgo, 3kwz, 3kx1 – hMCTSK+ pyrimidine inhibitor 3mpe, 3mpf – hMCTSK (mutant) + pyrimidine inhibitor 3h7d - hMCTSK (mutant) + chondroitin-4-sulfate 3c9e - hMCTSK + chondroitin-4-sulfate 3kwb - hMCTSK (mutant)+dioxo-triazine 3kw9 - hMCTSK +triazine 1yk8 - hMCTSK + cyanamide inhibitor 1yt7 - hMCTSK + ketoamide inhibitor 2aux, 2auz - hMCTSK + semicarbazone inhibitor 1ayu, 1ayv, 1ayw - hMCTSK + carbohydrazide inhibitor 2bdl, 1yk7, 1tu6, 1au3, 1au4 - hMCTSK + pyrrolidine inhibitor 1snk - hMCTSK + norleucine inhibitor 1nl6, 1nlj - hMCTSK+ azepanone inhibitor 1q6k - hMCTSK+carbamate inhibitor 1au0 - hMCTSK+ diacylaminoethyl ketone inhibitor 1au2 - hMCTSK+ propanone inhibitor 1atk – hMCTSK+guanidine inhibitor 1vsn - hMCTSK+ inhibitor 2ato – hMCTSK+myocrisin 1u9v, 1u9x, 1mem – hMCTSK+piperazine inhibitor 1u9w - hMCTSK+imidazole inhibitor 2ftd – MCTSK+azepan inhibitor – Macaca mulatta 2f7d – MCTSK (mutant)+nitrile inhibitor - rabbit


Cathepsin-L mature

3f75 – MCTSL +CTSL propeptide – Toxoplasma gondii 2p86 – TbMCTSL +K11002 2nqd - CTSL residues 1-220 (mutant)+chagasin – Trypanosoma cruzi 1mhw – hMCTSL +tripeptide 1icf – hMCTSL +MHC class II fragment


Procathepsin-L1

2o6x – hPCTSL1 (mutant) – Fasciola hepatica


Cathepsin-L1 mature

3iv2 – hMCTSL1 (mutant) 3k24 - hMCTSL1 (mutant) +tripeptide 3bc3 - hMCTSL1 +inhibitor 3h89, 3h8b, 3h8c - hMCTSL1 (mutant) + retro-binding inhibitor 3hwn, 3hha – hMCTSL1+pyrazole inhibitor


Cathepsin-L2 mature

3h6s – hMCTSL2+clitocypin 1fh0 – hMCTSL2 (mutant) +vinyl sulfone inhibitor


Procathepsin-S

2c0y – hPCTSS (mutant)


Cathepsin-S mature

3n3g - hMCTSS+ pyrimidine inhibitor 3kwn – hMCTSS (mutant)+ thioether acetamide 3iej - hMCTSS (mutant)+pyrazole inhibitor 2h7j, 2hxz- hMCTSS+triazole inhibitor 2r9m, 2r9n, 2r9o – hMCTSS+piperidine inhibitor 2op3, 2hhn, 2g7y, 2hh5, 2f1g – hMCTSS+aryl inhibitor 2fud, 2fra, 2frq, 2ft2, 1npz, 1nqc – hMCTSS+inhibitor 2fye, 2g6d – hMCTSS (mutant)+inhibitor 2fq9, 1ms6 – hMCTSS +nitrile inhibitor 1glo - hMCTSS (mutant)


Procathepsin-X

1deu - hPCTSX


Cathepsin-X mature

1ef7 – hMCTSX

Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Alexander Berchansky, Joel L. Sussman

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